Sofosbuvir and dalatasvir double-layer tablet and preparation method thereof
A technology of sofosbuvir and daclatasvir, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of different dissolution behaviors, and improve the accuracy of medication rate, improving dissolution rate and stability, and preventing loss
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Embodiment 1
[0042] For a Cable with Dallas oseltamivir phosphate Bouvet bilayer tablet, comprising a first ply and a second ply, the first ply comprises cords phosphorus Bouvet 200mg, mannitol 150mg, microcrystalline cellulose 250mg, cross-linked sodium carboxymethyl cellulose 30mg, povidone 50mg, 10mg magnesium stearate; Dara said second ply comprises oseltamivir 30mg, anhydrous lactose 75mg, microcrystalline cellulose 50mg, croscarmellose cellulose, sodium 5mg, povidone 5mg, magnesium stearate 10mg.
[0043] Cable phosphorus Bouvet above production method Dallas bilayer tablet as oseltamivir,
[0044] Preparation S1 cable phosphorus particles Bouvet
[0045] S11 micronization process: Weigh weight of said respective cable phosphorus Bouvet micronized treatment, the cable phosphorus particles after micronization Bouvet by less than 0.25mm;
[0046] The raw material mixed S12: Increment method using the same amount of phosphorus Bouvet cable with mannitol, microcrystalline cellulose and crosc...
Embodiment 2
[0057] Example 2: A Schodikikir with Dallawei Double-layer sheet including the first sheet and a second sheet, the first layer contains 400 mg, the mannitol 150mg, microcrystals Cellulose 200mg, 45 mg of crosslinked carboxymethylcellulose sodium crosslinked carboxymethylcellulose, 60 mg of stearate, magnesium stearate 45mg; the second layer contains 60 mg of Dallavi, anhydrous lactose 100mg, microcrystalline cellulose 100 mg, Crosslinked carboxymethylcellulose 10 mg, polyesterin 10 mg, magnesium stearate 20 mg.
[0058] The preparation method of the above-mentioned Schodikovir and Dallawei double-layer sheet is as follows.
[0059] Preparation of S1 Sony Phosphi Granules
[0060] S11 micronization treatment: Weigh the corresponding weight of the soil phosphori to carry out micronization treatment, so that the particles of the micronized sobblewell are less than 0.25 mm;
[0061] S12 raw material mixing: Use an equal amount of additive sodiol, microcrystalline, and cross-linked car...
Embodiment 3
[0071] Example 3: A Schodikikir and Dallawei Double-layer sheet including a first sheet and a second sheet, and the first sheet contains 200 mg, mannitol 100mg, microcrystals. Cellulose 150 mg, 3 mg of crosslinked carboxymethylcellulose, 50 mg of polyesterone, 20 mg of stearate. Corresponding, the second layer contains the following weight component, including Dallasiwell hydrochloride 33mg, anhydrous lactose 100mg, microcrystalline cellulose 50 mg, 5 mg of crosslinked carboxymethylcellulose 5mg, pp 10 mg , Stearate 15 mg.
[0072] The preparation method of the above-mentioned Schodikovir and Dallawei double-layer sheet is as follows.
[0073] Preparation of S1 Sony Phosphi Granules
[0074] S11 micronization treatment: Weigh the corresponding weight of the soil phosphori to carry out micronization treatment, so that the particles of the micronized sobblewell are less than 0.25 mm;
[0075] S12 raw material mixing: Use an equal amount of additive sodiol, microcrystalline, and cros...
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