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Soft tissue filling hydrogel for medical cosmetology and preparation method of soft tissue filling hydrogel

A hydrogel and soft tissue technology, which is applied in the field of medical cosmetology, can solve the problems of poor stability of soft tissue fillers and other problems, and achieve excellent filling effect, excellent needle penetration and filling effect, and improve needle penetration and filling effect. Effect

Pending Publication Date: 2021-02-12
南京思元医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] An object of the present invention is to solve the technical problems of soft tissue filler stability and poor needle penetration in the prior art

Method used

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  • Soft tissue filling hydrogel for medical cosmetology and preparation method of soft tissue filling hydrogel
  • Soft tissue filling hydrogel for medical cosmetology and preparation method of soft tissue filling hydrogel
  • Soft tissue filling hydrogel for medical cosmetology and preparation method of soft tissue filling hydrogel

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preparation example Construction

[0058] Figure 4 A schematic flowchart showing a method for preparing a soft tissue filling hydrogel according to an embodiment of the present invention. Such as Figure 4 Shown, this preparation method comprises:

[0059] In step S100, polyethylene glycol is used as an initiator and lactide is used as a monomer to obtain a poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid copolymer precursor or a poly-l-lactic acid-poly Ethylene glycol-poly lactic acid copolymer precursor;

[0060] Step S200, purifying the poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid copolymer precursor or the poly-l-lactic acid-polyethylene glycol-poly-l-lactic acid copolymer precursor by solvent-anti-solvent precipitation method to obtain Poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid copolymer or poly-l-lactic acid-polyethylene glycol-poly-l-lactic acid copolymer;

[0061] Step S300, reconstitute the poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid copolymer or ...

Embodiment 1

[0073] The embodiment of the present invention provides a method for preparing a soft tissue filling hydrogel, comprising the following steps:

[0074] 1) Weigh 100g of L-lactide and 300g of polyethylene glycol (10000Da) (polymerization ratio: 1:3) into a round bottom flask, heat to 110°C and stir until the two raw materials are completely melted and mixed evenly;

[0075] 2) Under stirring conditions, add 0.4 g of stannous octoate catalyst, and raise the reaction temperature to 130 ° C to initiate ring-opening polymerization of L-lactide for 18 hours to obtain a PLLA-PEG-PLLA copolymer precursor;

[0076] 3) Dissolve the PLLA-PEG-PLLA copolymer precursor with 2L of dichloromethane, then settle with 10L of n-hexane, repeat 5 times, and vacuum dry to obtain a purified PLLA-PEG-PLLA copolymer;

[0077] 4) Weigh 250g of PLLA-PEG-PLLA copolymer, 15g of sodium carboxymethylcellulose, 25g of mannitol and 10g of tranexamic acid and add them to 2.5 liters of normal saline for injectio...

Embodiment 2

[0080] The embodiment of the present invention provides a method for preparing a soft tissue filling hydrogel, comprising the following steps:

[0081]1) Weigh 80g of L-lactide and 320g of polyethylene glycol (10000Da) (polymerization ratio: 1:4) into a round bottom flask, heat to 110°C and stir until the two raw materials are completely melted and mixed evenly;

[0082] 2) Under stirring conditions, add 0.4 g of stannous octoate catalyst, and raise the reaction temperature to 130 ° C to initiate ring-opening polymerization of L-lactide for 12 hours to obtain a PLLA-PEG-PLLA copolymer precursor;

[0083] 3) Dissolve the PLLA-PEG-PLLA copolymer precursor with 2L of dichloromethane, then settle with 10L of n-hexane, repeat 5 times, and vacuum dry to obtain a purified PLLA-PEG-PLLA copolymer;

[0084] 4) Weigh 250g of PLLA-PEG-PLLA copolymer, 15g of sodium hyaluronate, 25g of mannitol and 10g of tranexamic acid into 2.5 liters of normal saline for injection and stir magnetically ...

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Abstract

The invention provides soft tissue filling hydrogel for medical cosmetology and a preparation method of the soft tissue filling hydrogel. The soft tissue filling hydrogel comprises a poly-L-lactic acid-polyethylene glycol-poly-L-lactic acid copolymer or a poly-racemic lactic acid-polyethylene glycol-poly-racemic lactic acid copolymer. According to the scheme of the embodiment of the invention, thePLLA-PEG-PLLA copolymer or the PDLLA-PEG-PDLLA copolymer is used as a main substance of the soft tissue filling hydrogel, so that the soft tissue filling hydrogel has excellent water solubility, biocompatibility and biodegradability, and has the advantages of being good in needle passing property, quick in effect, outstanding in filling effect, low in toxic and side effects, capable of promotingregeneration of fibroblasts and collagen and the like; and the soft tissue filling hydrogel is suitable for soft tissue filling in plastic surgery.

Description

technical field [0001] The invention relates to the technical field of medical cosmetology, in particular to a soft tissue filling hydrogel for medical cosmetology and a preparation method thereof. Background technique [0002] When poly-L-lactic acid is used as a medical cosmetic filling material, it usually needs to be prepared into micron-sized particles or microspheres, and then injected into the deep tissue of the skin through a syringe to achieve the effect of filling cosmetics. [0003] However, the soft tissue filler prepared by such polylactic acid microspheres has extremely poor stability and needle penetration due to the size of the microspheres and the dispersion of the aqueous phase, and thicker needles are usually required in clinical use. (below 26G) for injection, and it is very easy to cause needle blocking due to the aggregation of microspheres during the injection process, which greatly increases the difficulty of operation for doctors and the pain of pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/26A61L27/50A61L27/54
CPCA61L27/52A61L27/26A61L27/50A61L27/54A61L2430/34A61L2400/06A61L2300/602A61L2300/40A61L2300/252A61L2300/23A61L2300/236A61L2300/232A61L2300/214C08L67/04
Inventor 丰祝刚
Owner 南京思元医疗技术有限公司
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