Application of diosmetin(4-O-methyl) glucoside compound in preparation of lipid-lowering drugs

A technology of diosmin and glucoside, which is applied in the fields of drug combination, sugar derivatives, organic chemistry, etc., and can solve the problem of few reports on lipid-lowering activity
CN112358516AActive Publication Date: 2021-02-12INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Publication Date
2021-02-12

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Abstract

The invention discloses an application of a diosmetin(4-O-methyl) glucoside compound as a lipid-lowering drug; in a biological activity test, the compound shows down-regulation or inhibition of mouse3T3-L1 precursor adipocyte proliferation and significant reduction of the number of lipid droplets generated in a cell differentiation process, and aglycones of the diosmetin(4-O-methyl) glucoside compound also have the functions, but the effect of the compound is more obvious; compared with the aglycones, the compound has the advantages that the water solubility of the compound is remarkably enhanced, the conversion rate of the compound is high, and the compound has wider application value.
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Description

Technical field:

[0001] The invention belongs to the field of lipid-lowering drugs, in particular to the use of diosmin (4-O-methyl) glucoside compounds in lipid-lowering drugs. Background technique:

[0002] Diosmetin is a common natural flavonoid plant secondary metabolite, which is widely found in natural medicines such as chrysanthemum, spearmint, and spider incense, and in fruits such as lemons, citrus, and peanuts. Dioxynignin is considered to have a variety of biological and pharmacological activities on human health, such as antioxidant, antibacterial, antiviral, anti-inflammatory, antitumor, antithrombotic and hepatoprotective activities, so it has attracted widespread attention and can be used in Food, medicine and other fields can improve health and prevent diseases. However, diosmin is only slightly soluble in water, has a low extraction rate, has certain phytotoxicity, and has poor metabolic stability in mammals. And bioavailability decrease, which greatly hin...

Claims

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