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Antisecretory factor for use in treatment and/or prevention of acute respiratory failure

A technology of antisecretory factors and their uses, which is applied in the field of application of antisecretory factors in the treatment and/or prevention of acute respiratory failure, and can solve problems such as long-term dyspnea in infants

Pending Publication Date: 2021-02-12
ラントメネンメディカルアーベー
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most babies recover from BPD, but some have long-term breathing difficulties

Method used

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  • Antisecretory factor for use in treatment and/or prevention of acute respiratory failure
  • Antisecretory factor for use in treatment and/or prevention of acute respiratory failure
  • Antisecretory factor for use in treatment and/or prevention of acute respiratory failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1 further demonstrates that AF-16 treatment reduces structural abnormalities caused by induced traumatic lung injury compared to that recorded in vehicle-treated reference animals, and demonstrates a significant increase in cardiovascular parameters (including blood pressure and heart rate) No adverse side effects were shown.

[0097] The available results strongly suggest that AF-16 treatment has a statistically significant beneficial effect on cardiac output in acute respiratory failure ( Figure 4 ).

[0098] Accordingly, the present invention is primarily concerned with the treatment of the respiratory and cardiovascular systems.

[0099]In the respiratory system, it is of utmost importance to separate the breathing air from the blood and interstitial fluid by tissues with a thickness in the range of a few tenths of a micron, to enable adequate uptake and exchange of oxygen and carbon dioxide. For proper normal (ie healthy) function of the airways, includi...

example

[0132] Examples of solvents include, but are not limited to, water, alcohol, blood, plasma, cerebrospinal fluid, ascitic fluid, and lymph.

[0133] Examples of buffers include, but are not limited to, citric acid, acetic acid, tartaric acid, lactic acid, hydrogen phosphoric acid, bicarbonate, phosphate, diacetamide, and the like.

[0134] Examples of chelating agents include, but are not limited to, EDTA and citric acid.

[0135] Examples of antioxidants include, but are not limited to, butylated hydroxyanisole (BHA), ascorbic acid and its derivatives, tocopherol and its derivatives, cysteine, and mixtures thereof.

[0136] Examples of diluents and disintegrants include, but are not limited to, lactose, sucrose, emdex, calcium phosphate, calcium carbonate, calcium sulfate, mannitol, starch, and microcrystalline cellulose.

[0137] Examples of binders include, but are not limited to, sucrose, sorbitol, gum arabic, sodium alginate, gelatin, chitosan, starch, cellulose, carboxym...

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Abstract

The present invention relates to the use of antisecretory factor (AF) protein, homologues, and / or fragments thereof, having equivalent functional activity, and / or a pharmaceutically active salt thereof, for restoring and / or normalizing epithelial barrier function for treating and / or preventing acute respiratory failure. In particular, antisecretory factor (AF) protein, homologues, and / or fragmentsthereof, having equivalent functional activity, and / or a pharmaceutically active salt thereof, is (are) herein disclosed to be of use in counteracting and / or normalizing fluid transfer across epithelial cell barriers with a significant impact on a large proportion of patients with traumatic lung injury, such as but not limited to patients suffering from abnormal accumulation of fluid in the lungalveoli and / or bronchioles selected from the list of patients suffering from BPD, ARDS, IRDS, sepsis, SIRS, acute pulmonary edema, pneumonia, interstitial pulmonary edema and cardiovascular lung disorder.

Description

technical field [0001] The present invention relates to antisecretory factor (AF) protein, its homologues and / or fragments thereof having equivalent functional activity, and / or pharmaceutically active salts thereof for the recovery and / or normalization of the onset of acute respiratory failure (ARF) Mechanisms of use of epithelial barrier function. [0002] In particular, disclosed herein are antisecretory factor (AF) proteins, homologues thereof and / or fragments thereof having equivalent functional activity, and / or pharmaceutically active salts thereof upon digestion and / or normalization of fluid transfer across epithelial barriers This has a major impact on most patients with acute respiratory failure (eg, patients with abnormal accumulation of fluid in the alveoli and bronchioles due to acute respiratory failure (ARF)), including but not limited to : ARDS (Acute Respiratory Distress Syndrome) and IRDS (Infant Respiratory Distress Syndrome). Background technique [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17C07K14/47A61P11/00
CPCA61K38/1709C07K14/47
Inventor 安德斯·拉尔森
Owner ラントメネンメディカルアーベー