Functionalized biological hybrid micro-nano motor and preparation method thereof

A bio-hybrid, micro-nano technology, applied in the field of material technology and micro-nano manufacturing, can solve the problems of inability to solve the core driving problem of synthetic micro-nano motors, underutilization of biological entity functions, etc., and achieve uniform size and rapid detection. , the effect of enhancing magnetic responsiveness and magnetic motion control

Inactive Publication Date: 2021-02-19
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the functions of these biological entities are underutilized
For example, relying solely on the method of cell membrane-coated micro-nano motors cannot solve the core driving problem of

Method used

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  • Functionalized biological hybrid micro-nano motor and preparation method thereof
  • Functionalized biological hybrid micro-nano motor and preparation method thereof
  • Functionalized biological hybrid micro-nano motor and preparation method thereof

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Example Embodiment

[0030]In view of the above-mentioned background art problems, the present invention provides a functionalized biological hybrid micro / nano motor and a preparation method thereof.

[0031]The functionalized biological hybrid micro / nano motor includes a biological entity inner core, a magnetic nanoparticle coating and a probe layer. The inner core of a biological entity can be natural plant seeds, fungal spores, pollen, etc., which have a unique and complex three-dimensional structure and can be cultured or obtained in large quantities. On the surface of the inner core of the biological entity is a magnetic nanoparticle coating for driving and manipulating micro-nano motors, which can be self-assembled by chemically adsorbed and deposited magnetic nanoparticles. On the surface of the inner core of the biological entity wrapped in the magnetic nano-coating, there are probes immobilized by self-assembled functional groups. The probes include carbon dots with fluorescence emission and respo...

Example Embodiment

[0035]Example

[0036]Taking the spore-based micro / nano motor functionalized with oligosaccharides as an example, the functionalized biological hybrid micro / nano motor and its preparation method are described in detail.

[0037]The preparation method includes:

[0038]Step 1. Pre-treat Ganoderma or Lycopodium spores by sonicating them in 200 mL of absolute ethanol for 30 minutes, sonicating them in 200 mL of deionized water for 10 minutes, and washing with deionized water several times to remove impurities on the outer membrane and inner core. Freeze and dry for later use.

[0039]Step 2. Ultrasonic disperse the spores pretreated in step 1 into 60 mL of deionized water, and stir for 5 minutes to form a brown suspension of uniformly dispersed spores. Then add FeSO to the above suspension4After stirring for 20 minutes, add 20mL ammonia water (25%-27wt%) dropwise, and the dropping time is controlled within 10 minutes. After sealing and further stirring for 2h, the spores wrapped in black magnetic ...

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Abstract

The invention belongs to the field of material technology and micro-nano manufacturing, and relates to a functionalized biological hybrid micro-nano motor and a preparation method thereof. The functionalized biological hybrid micro-nano motor comprises a biological entity inner core, a magnetic nanoparticle coating and a probe layer. According to the invention, fungal spores, pollen and micro/nano-scale plant seeds are selected as the inner core, so that the inner core is easy to obtain or massively culture, and the material is uniform in size and easy to control; and the inner core and the nano-particles are hybridized through a step-by-step coating method, and a probe is loaded on the surface of the nano-coating. The functionalized biological hybrid micro-nano motor can actively move under accurate control, is very easy to observe, and overcomes the defects in the prior art.

Description

technical field [0001] The invention belongs to the field of material technology and micro-nano manufacturing, and relates to a functional biohybrid micro-nano motor and a preparation method thereof. Background technique [0002] Micro-nano motors (also known as micro-nano robots) realize autonomous and continuous motion in three-dimensional space by converting external energy (light, electricity, magnetism, heat, chemical energy, etc.) Operation tasks. Its autonomous continuous motion in different liquid environments can lead to both microscale eddy currents and surface dynamic chemistry. The synergy of these two effects can not only realize the microscopic mixing of solutions, accelerate the diffusion of solute molecules, and increase the rate and yield of chemical reactions, but also enable micro-nano motors to participate in various dynamic reactions at the same time as dynamic active reactors, improving the interaction between functional molecules and target molecules....

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/65G01N21/64
CPCC09K11/025C09K11/65G01N21/6428G01N2021/6432
Inventor 张亚斌肖林李国强蔡勇杨益
Owner SOUTHWEAT UNIV OF SCI & TECH
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