In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof

A technology of in situ mineralization and composite materials, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problem that the mechanical properties cannot match with hard bone tissue, lack of fine control of material structure and surface, and mechanical stability of hydrogel materials It is beneficial to the directional adhesion of cells and the induction of osteogenic differentiation, good osseointegration and mechanical stability, and excellent mechanical properties.

Active Publication Date: 2021-02-26
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The above-mentioned existing technologies are all based on the technology of blending hydroxyapatite powder and polymer solution for repolymerization or molding to prepare hydroxyapatite hydrogel, which is often difficult to ensure uniformity, mechanical properties cannot match hard bone tissue, compression or The t

Method used

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  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof
  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof
  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof

Examples

Experimental program
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Example Embodiment

[0049]Example 1

[0050]This embodiment provides an in-situ mineralized biomimetic bone hydrogel composite material with an oriented structure, and its preparation method is as follows:

[0051](1) Delignified wood chips: The wood chips are made of cypress, processed into a cube with a thickness of 2 mm and a side length of 10 mm. Firstly, the wood chips are immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-liquid ratio of 1:35 (g / g), put the wood chips into deionized water, add sodium chlorite (0.6g / 1g wood chips) and acetic acid (0.6mL / 1g wood chips), and heat the system to 80 React at ℃ for 6h. After the reaction, the wood chips are taken out, washed with deionized water three times, and dried as a template;

[0052](2) Place the template prepared in step (1) in a 3% sodium alginate aqueous solution, vacuum to 200Pa, hold for 15 minutes, then vent, repeat 5 times to fill the template with sodium alginate aqueou...

Example Embodiment

[0054]Example 2

[0055]This embodiment provides an in-situ mineralized biomimetic bone hydrogel composite material with an oriented structure, and its preparation method is as follows:

[0056](1) Delignified wood chips: The wood chips are eucalyptus, processed into a cube with a thickness of 3 mm and a side length of 10 mm. Firstly, the wood chips are immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-liquid ratio of 1:30 (g / g), put the wood chips into deionized water, add sodium chlorite (0.8g / 1g wood chips) and acetic acid (0.8mL / 1g wood chips), and heat the system to 70 React at ℃ for 6h. After the reaction, the wood chips are taken out, washed with deionized water three times, and dried as a template;

[0057](2) Place the template prepared in step (1) in a natural collagen aqueous solution with a mass fraction of 5%, vacuum to 100 Pa, hold for 20 minutes, then deflate, repeat 7 times to fill the template wit...

Example Embodiment

[0059]Example 3

[0060]This embodiment provides an in-situ mineralized biomimetic bone hydrogel composite material with an oriented structure, and its preparation method is as follows:

[0061](1) Delignified wood chips: The wood chips are made of beech wood, processed into a cube with a thickness of 5 mm and a side length of 15 mm. Firstly, the wood chips are immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-liquid ratio of 1:40 (g / g), put the wood chips into deionized water, add sodium chlorite (1g / 1g wood chips) and acetic acid (1mL / 1g wood chips), and heat the system to 75℃ for reaction 8h. After the reaction, the wood chips are taken out, washed with deionized water three times, and dried as a template;

[0062](2) Place the template prepared in step (1) in a chitosan aqueous solution with a mass fraction of 2%, evacuate to 300Pa, hold for 10 minutes, then vent, repeat 5 times to fill the template with the c...

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Abstract

The invention relates to an in-situ mineralized bionic bone hydrogel composite material with an oriented structure as well as a preparation method and application thereof, which comprises a natural plant fiber template, natural polymer hydrogel directionally filled in the natural plant fiber template and hydroxyapatite directionally deposited in the natural plant fiber template. The hydrogel composite material has a three-dimensional porous structure and is anisotropic, which overcomes the problem of uneven distribution of hydroxyapatite particles in the hydrogel matrix; the material has super-strong tensile strength, compression strength, bending strength and toughness, and the mechanical properties are matched with those of hard bone tissues. The material is beneficial to induce pre-osteoblast adhesion and osteogenic differentiation, promote new bone growth, has good osseointegration and mechanical stability, and is suitable for large-area hard bone tissue repair; in addition, the material has adjustable surface activity, and fine adjustment and control of the structure and the surface can be achieved.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a biomimetic bone hydrogel composite material and its preparation method and application, in particular to an in-situ mineralized biomimetic bone hydrogel composite material with an orientation structure and its preparation method and apply. Background technique [0002] Hydrogels have broad application prospects in tissue engineering because their three-dimensional network morphology can simulate the structure of extracellular matrix and facilitate material exchange. However, the mechanical properties of hydrogel are relatively soft, basically do not have the load-bearing effect, poor fatigue resistance, poor mechanical stability, and are not conducive to being used as a load-bearing tissue engineering scaffold. It needs to be blended with metals, organics, bioceramics, etc. to improve its mechanical properties. performance to meet load-bearing needs. As...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24A61L27/20A61L27/12A61L27/50A61L27/52A61L27/56
CPCA61L27/3637A61L27/20A61L27/24A61L27/12A61L27/52A61L27/56A61L27/50A61L2430/02C08L5/04C08L5/08
Inventor 王晓飞方驹任富增
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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