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In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof

A technology of in situ mineralization and composite materials, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problem that the mechanical properties cannot match with hard bone tissue, lack of fine control of material structure and surface, and mechanical stability of hydrogel materials It is beneficial to the directional adhesion of cells and the induction of osteogenic differentiation, good osseointegration and mechanical stability, and excellent mechanical properties.

Active Publication Date: 2021-02-26
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned existing technologies are all based on the technology of blending hydroxyapatite powder and polymer solution for repolymerization or molding to prepare hydroxyapatite hydrogel, which is often difficult to ensure uniformity, mechanical properties cannot match hard bone tissue, compression or The tensile modulus basically does not exceed 10MPa, and the osseointegration is not strong; and the fine control of the material structure and surface is lacking; in addition, the mechanical stability of the hydrogel material based on blending and crosslinking is poor, which is not conducive to the repair of large tissue defects

Method used

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  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof
  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof
  • In-situ mineralized bionic bone hydrogel composite material with oriented structure as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0050] This embodiment provides a biomimetic bone hydrogel composite material with orientation structure in situ mineralization, the preparation method of which is as follows:

[0051] (1) Delignification treatment of wood chips: the wood chips are cypress, processed into a cube with a thickness of 2 mm and a side length of 10 mm. First, wood chips were immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-to-liquid ratio of 1:35 (g / g), put wood chips into deionized water, add sodium chlorite (0.6g / 1g wood chips) and acetic acid (0.6mL / 1g wood chips), and heat the system to 80 ℃ reaction 6h. After the reaction, the wood chips were taken out, washed three times with deionized water, and dried as templates;

[0052] (2) Place the template prepared in step (1) in an aqueous solution of sodium alginate with a mass fraction of 3%, evacuate to 200 Pa, keep it for 15 minutes, then deflate, repeat 5 times, an...

Embodiment 2

[0055] This embodiment provides a biomimetic bone hydrogel composite material with orientation structure in situ mineralization, the preparation method of which is as follows:

[0056] (1) Delignification treatment of wood chips: the wood chips are eucalyptus, processed into a cube with a thickness of 3 mm and a side length of 10 mm. First, wood chips were immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-to-liquid ratio of 1:30 (g / g), put wood chips into deionized water, add sodium chlorite (0.8g / 1g wood chips) and acetic acid (0.8mL / 1g wood chips), and heat the system to 70 ℃ reaction 6h. After the reaction, the wood chips were taken out, washed three times with deionized water, and dried as templates;

[0057] (2) Place the template prepared in step (1) in a natural collagen aqueous solution with a mass fraction of 5%, evacuate to 100Pa, keep for 20min, then deflate, repeat 7 times, so that the...

Embodiment 3

[0060] This embodiment provides a biomimetic bone hydrogel composite material with orientation structure in situ mineralization, the preparation method of which is as follows:

[0061] (1) Delignified wood chips: the wood chips are beech wood, processed into a cube with a thickness of 5 mm and a side length of 15 mm. First, wood chips were immersed in deionized water, treated at 80°C for 1 hour to remove impurities and dust, dried and weighed. According to the solid-to-liquid ratio of 1:40 (g / g), put wood chips into deionized water, add sodium chlorite (1g / 1g wood chips) and acetic acid (1mL / 1g wood chips), and heat the system to 75°C for reaction 8h. After the reaction, the wood chips were taken out, washed three times with deionized water, and dried as templates;

[0062] (2) Place the template prepared in step (1) in a chitosan aqueous solution with a mass fraction of 2%, vacuumize to 300Pa, keep for 10min, then deflate, repeat 5 times, and fill the chitosan aqueous solut...

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Abstract

The invention relates to an in-situ mineralized bionic bone hydrogel composite material with an oriented structure as well as a preparation method and application thereof, which comprises a natural plant fiber template, natural polymer hydrogel directionally filled in the natural plant fiber template and hydroxyapatite directionally deposited in the natural plant fiber template. The hydrogel composite material has a three-dimensional porous structure and is anisotropic, which overcomes the problem of uneven distribution of hydroxyapatite particles in the hydrogel matrix; the material has super-strong tensile strength, compression strength, bending strength and toughness, and the mechanical properties are matched with those of hard bone tissues. The material is beneficial to induce pre-osteoblast adhesion and osteogenic differentiation, promote new bone growth, has good osseointegration and mechanical stability, and is suitable for large-area hard bone tissue repair; in addition, the material has adjustable surface activity, and fine adjustment and control of the structure and the surface can be achieved.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a biomimetic bone hydrogel composite material and its preparation method and application, in particular to an in-situ mineralized biomimetic bone hydrogel composite material with an orientation structure and its preparation method and apply. Background technique [0002] Hydrogels have broad application prospects in tissue engineering because their three-dimensional network morphology can simulate the structure of extracellular matrix and facilitate material exchange. However, the mechanical properties of hydrogel are relatively soft, basically do not have the load-bearing effect, poor fatigue resistance, poor mechanical stability, and are not conducive to being used as a load-bearing tissue engineering scaffold. It needs to be blended with metals, organics, bioceramics, etc. to improve its mechanical properties. performance to meet load-bearing needs. As...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/24A61L27/20A61L27/12A61L27/50A61L27/52A61L27/56
CPCA61L27/3637A61L27/20A61L27/24A61L27/12A61L27/52A61L27/56A61L27/50A61L2430/02C08L5/04C08L5/08
Inventor 王晓飞方驹任富增
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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