Water-soluble antibacterial spray and application thereof

A water-soluble, spray technology, applied in the direction of application, bactericide, biocide, etc., can solve the problems of not being in direct contact with people, metal corrosion, human body irritation, etc., to achieve biological safety, no stimulation, no reaction Low temperature conditions, the effect of continuous and stable effect

Active Publication Date: 2021-03-02
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Antibacterial sprays currently used in the market include 84 disinfectant, peracetic acid, glutaraldehyde and medical alcohol, among which the most common is the disinfectant containing 75% alcohol. Although more than 75% alcohol can play a bactericidal effect, But when it needs to be sprayed on human skin, it will not only cause some damage to the skin, but also has the possibility of damaging the skin for sensitive muscles, pregnant women and children.
The disinfection and sterilization time of 84 disinfectant is 10-30 minutes. It is corrosive to metal and irritating to the human body, so it cannot be in direct contact with people.

Method used

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  • Water-soluble antibacterial spray and application thereof
  • Water-soluble antibacterial spray and application thereof
  • Water-soluble antibacterial spray and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Add 4g of cellulose powder to 200mL of deionized water, stir well, add 2mol / L hydrochloric acid to make the solution pH = 2, then add 5.28g of sodium periodate and 3.364g of sodium chloride and react in a water bath at 50°C 3h, and finally add 4g of polyethyleneimine and react in a water bath at 50°C for 3h to obtain an aminated cellulose material; the aminated cellulose material is precipitated with 4 times the volume of absolute ethanol, washed 3 times, and dried in a vacuum oven at 60°C for later use.

[0039] (2) The composition ratio of the antibacterial spray is: water-soluble aminated cellulose 3g / L; glycerin: 50-100g / L; citric acid: 1-10g / L; water: balance.

[0040] (3) Co-cultivation antibacterial experiment process: Add 15g agar powder, 10g peptone, 10g sodium chloride and 5g yeast powder into the container, add deionized water to 1L, and stir evenly to prepare a solid medium. Add 10g of peptone, 10g of sodium chloride and 5g of yeast powder into the conta...

Embodiment 2

[0050] The difference between this embodiment and Example 1 is that the water-soluble antibacterial spray is made of 4g / L water-soluble aminated cellulose, 50-100g / L glycerin, 1-10g / L citric acid and the rest of the pure water consist of. Other operations are the same as in Example 1.

[0051] Experimental results:

[0052] The antibacterial spray that embodiment 2 prepares is as shown in table 3 and table 4 by the result of co-cultivation antibacterial experiment and human skin antibacterial simulation experiment; Figure 4 and Figure 5 As shown, wherein, the antibacterial rate to Staphylococcus aureus reaches 100%, and the antibacterial rate to Escherichia coli reaches 88%.

[0053] Table 3 co-culture antibacterial test results

[0054]

[0055] Table 4 Results of human skin antibacterial simulation experiment

[0056]

Embodiment 3

[0058] The difference between this embodiment and Example 1 is that the water-soluble antibacterial spray is made of 5g / L water-soluble aminated cellulose, 50-100g / L glycerin, 1-10g / L citric acid and the rest of the pure water consist of. Other operations are the same as in Example 1.

[0059] Experimental results:

[0060] The antibacterial spray that embodiment 3 prepares is as shown in table 5 and table 6 by the result of co-cultivation antibacterial experiment and human skin antibacterial simulation experiment; Figure 6 and Figure 7 As shown, wherein, the antibacterial rate to Staphylococcus aureus reaches 100%, and the antibacterial rate to Escherichia coli reaches 99.6%.

[0061] Table 5 co-culture antibacterial test results

[0062] bacteria Staphylococcus aureus Escherichia coli Sterilization rate (%)) 100 99.96

[0063] Table 6 Results of human skin antibacterial simulation experiment

[0064]

[0065] Such as Figure 8 Shown are t...

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Abstract

The invention discloses a water-soluble antibacterial spray and application thereof. The formula of the antibacterial spray comprises the following components: 3-5 g / L of water-soluble aminated cellulose; 50-100 g / L of glycerol; 1-10 g / L of citric acid; and the balance of water. The spray is prepared by the following steps: uniformly mixing and stirring the components according to the mass to obtain the antibacterial spray disclosed by the invention. The antibacterial spray disclosed by the invention is good in stability, safe, non-irritant and free of toxic and side effects, can exert an excellent sterilization effect in a short time, can be used for sterilization and disinfection of human epidermis, object surfaces and public places, and has a wide application prospect in the fields of biomedical treatment, hygiene protection and the like.

Description

technical field [0001] The invention belongs to the technical field of antibacterial and disinfection in medical and sanitation, and in particular relates to a water-soluble antibacterial spray and its application. Background technique [0002] Antibacterial sprays currently used in the market include 84 disinfectant, peracetic acid, glutaraldehyde and medical alcohol, among which the most common is the disinfectant containing 75% alcohol. Although more than 75% alcohol can play a bactericidal effect, But when it needs to be sprayed on human skin, it will not only cause some damage to the skin, but also may damage the skin for sensitive muscles, pregnant women and children. The disinfection and sterilization time of 84 disinfectant is 10-30 minutes. It is corrosive to metal and irritating to the human body, so it cannot be in direct contact with people. Therefore, the best bactericidal spray can achieve the effect of short-term sterilization, mildew removal, food grade and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/365A61K8/34A61K8/04A61Q17/00A61Q19/10A01N43/16A01N37/36A01N25/06A01P1/00A01P3/00
CPCA61K8/731A61K8/365A61K8/345A61K8/046A61Q19/10A61Q17/005A01N43/16A01N37/36A01N25/06Y02A50/30
Inventor 刘琳孙晓青姚菊明
Owner ZHEJIANG SCI-TECH UNIV
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