Medical Zn-Cu-Mn-Zr alloy capable of being degraded in living body and high in strength and toughness

A zn-cu-mn-zr, biological technology, applied in prosthesis, medical science, surgery, etc., can solve problems such as aging work hardening ability of zinc alloy, achieve good biocompatibility, improve mechanical properties, avoid Pain and Burden Effects

Active Publication Date: 2021-03-02
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to improve the overall performance of biomedical zinc alloys in view of actual clinical needs, focus on solving the problem of "aging" and low work hardening ability of zinc alloys, and propose a biodegradable high-strength medical Zn- Cu-Mn-Zr alloy; this alloy has excellent mechanical properties, ideal uniform corrosion resistance, good biocompatibility, anti-aging and high work hardening ability, suitable for the preparation of degradable bone implants and Vascular stents, staples, vascular clips and other implanted devices

Method used

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  • Medical Zn-Cu-Mn-Zr alloy capable of being degraded in living body and high in strength and toughness
  • Medical Zn-Cu-Mn-Zr alloy capable of being degraded in living body and high in strength and toughness
  • Medical Zn-Cu-Mn-Zr alloy capable of being degraded in living body and high in strength and toughness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Alloy composition Zn-1.5Cu-1.0Mn-0.5Zr. Cut a certain length of ingot, after 400℃, 24h solid solution treatment, extrusion into The extrusion temperature is 180°C and the extrusion ratio is 9. At room temperature and a tensile strain rate of 1×10 -3 Under certain test conditions, the mechanical properties that can be obtained under this process are: the tensile strength is 350MPa, the yield strength is 340MPa, and the elongation is 37%. The corrosion rate of the material in the C-SBF simulated body fluid environment is 50 μm / year. Biological test results show that the material has no obvious cytotoxicity and good biocompatibility. The antibacterial rates of Staphylococcus aureus and Escherichia coli were all above 90%. After the extruded alloy is kept at 380°C for 0.5 hours, the yield strength of the alloy is 210MPa, the tensile strength is 280MPa, the elongation is 30%, and the strain hardening exponent n is 0.23 at the stage of true strain 5%-15%. The alloy has ...

Embodiment 2

[0045] Alloy composition Zn-2.0Cu-0.5Mn-0.5Zr. Cut a certain length of ingot, after 400℃, 24h solid solution treatment, extrusion into The extrusion temperature is 180°C and the extrusion ratio is 9. At room temperature and a tensile strain rate of 1×10 -3 Under certain test conditions, the mechanical properties that can be obtained under this process are: the tensile strength is 360MPa, the yield strength is 348MPa, and the elongation is 32%. The corrosion rate of the material in the C-SBF simulated body fluid environment is 53 μm / year. Biological test results show that the material has no obvious cytotoxicity and good biocompatibility. The antibacterial rates of Staphylococcus aureus and Escherichia coli were all above 90%. After the extruded alloy is kept at 380°C for 0.5 hours, the yield strength of the alloy is 220MPa, the tensile strength is 295MPa, the elongation is 26%, and the strain hardening exponent n is 0.24 at the stage of true strain 5%-15%. The alloy has ...

Embodiment 3

[0047] Alloy composition Zn-2.5Cu-0.75Mn-0.5Zr. Cut a certain length of ingot, after 400℃, 24h solid solution treatment, extrusion into The extrusion temperature is 180°C and the extrusion ratio is 9. At room temperature and a tensile strain rate of 1×10 -3 Under certain test conditions, the mechanical properties that can be obtained under this process are: the tensile strength is 375MPa, the yield strength is 360MPa, and the elongation is 33%. The corrosion rate of the material in the C-SBF simulated body fluid environment is 53 μm / year. Biological test results show that the material has no obvious cytotoxicity and good biocompatibility. The antibacterial rates of Staphylococcus aureus and Escherichia coli were all above 90%. After the extruded alloy is kept at 380°C for 0.5 hours, the yield strength of the alloy is 240MPa, the tensile strength is 305MPa, the elongation is 26%, and the strain hardening exponent n is 0.23 at the stage of true strain 5%-15%. The alloy has...

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Abstract

The invention discloses a medical Zn-Cu-Mn-Zr alloy capable of being degraded in a living body and high in strength and toughness. Zn, Cu, Mn and Zr elements are included, the content of Cu is largerthan 0 and smaller than or equal to 4%, the content of Mn is larger than 0 and smaller than or equal to 2%, the content of Zr is larger than 0 and smaller than or equal to 2%, and the balance is Zn. The corrosion rate of the alloy material in simulated body fluid is 35-71 microns/year, and a uniform corrosion degradation mode is shown; and under the conditions of the room temperature and the tensile strain rate of 1 * 10<-3>, the tensile properties are as follows: the yield strength is 200-420 MPa, the tensile strength is 210-440 MPa, and the elongation is 20-65%. The antibacterial rate on staphylococcus aureus and escherichia coli is 90% or higher. After the temperature at 380 DEG C is kept for 0.5 hour, the strain hardening index n is greater than or equal to 0.2 at the stage of true strain of 5%-15%; and moreover, no obvious cytotoxicity exists, and the biocompatibility is relatively good.

Description

technical field [0001] The invention relates to a biodegradable high-strength and tough medical Zn-Cu-Mn-Zr alloy, specifically, a high-strength alloy with work hardening and aging resistance suitable for the preparation of biodegradable implanted devices. Tough medical zinc alloy material. Background technique [0002] At present, most of the materials used in the preparation of implanted devices widely used in clinical practice are inert materials, such as stainless steel, titanium alloy, etc. These materials have good stability in the human body, good biocompatibility, and good molding performance. However, the common problems of the implanted devices made of such materials after implantation are: they exist as foreign bodies after implantation, and need to take anti-rejection drugs for a long time, such as vascular stent products; It is removed through secondary surgery, such as bone plates and bone nails. This has not only increased the suffering of patients and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C18/02C22F1/16A61L27/04A61L27/58A61L31/02A61L31/14
CPCC22C18/02C22F1/165A61L27/047A61L27/58A61L31/022A61L31/148
Inventor 黄华牛佳林柯贵州袁广银
Owner SHANGHAI JIAO TONG UNIV
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