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Preparation and application of degradable, biocompatible, high-strength chitin hydrogel

A biocompatible, chitin technology, applied in non-active ingredients medical preparations, drug combinations, tissue regeneration, etc. Compatibility and other issues, to achieve the effect of improving mechanical properties, improving mechanical properties, biodegradability and swelling ability

Active Publication Date: 2022-03-04
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the tensile strength of most chitin hydrogels is only tens to 100 KPa, and the elongation at break is relatively small, which cannot meet the requirements of biomedical applications.
In addition, excessive use of toxic cross-linking agents such as epichlorohydrin and glutaraldehyde can improve the mechanical properties of hydrogels, but at the same time reduce the biocompatibility of hydrogels, limiting their application in biomedicine. application

Method used

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  • Preparation and application of degradable, biocompatible, high-strength chitin hydrogel
  • Preparation and application of degradable, biocompatible, high-strength chitin hydrogel
  • Preparation and application of degradable, biocompatible, high-strength chitin hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Use 16% potassium hydroxide / 4% urea to dissolve chitin to prepare a chitin solution with a concentration of 5%, and add the silane coupling agent KH550 dropwise at 0°C (mass ratio of KH550 to chitin solution=3:100) and stirred at a speed of 700rpm for 1h, and after centrifugal defoaming, the chemically crosslinked chitin gel was obtained by casting method, and then the gel was transferred to an ethanol coagulation bath with a concentration of 95% and a temperature of 4°C for physical crosslinking for 8h. Finally, the hydrogel obtained by washing with water until neutral has certain light transmittance, high strength and high toughness, biodegradability and biocompatibility.

Embodiment 2

[0036] Use 16% potassium hydroxide / 4% urea to dissolve chitin to prepare a chitin solution with a concentration of 5%, and add the silane coupling agent KH560 dropwise at 0°C (mass ratio of KH560 to chitin solution=3:100) and stirred at a speed of 700rpm for 1h, and after centrifugal defoaming, the chemically crosslinked chitin gel was obtained by casting method, and then the gel was transferred to an ethanol coagulation bath with a concentration of 95% and a temperature of 4°C for physical crosslinking for 8h. Finally, the hydrogel obtained by washing with water until neutral has certain light transmittance, high strength and high toughness, biodegradability and biocompatibility.

Embodiment 3

[0038] Use 16% potassium hydroxide / 4% urea to dissolve chitin to prepare a chitin solution with a concentration of 5%, and add the silane coupling agent KH560 dropwise at 0°C (mass ratio of KH560 to chitin solution=3:100) and stirred at a speed of 700rpm for 1h, and after centrifugal defoaming, the chemically crosslinked chitin gel was obtained by casting method, and then the gel was transferred to an ethanol coagulation bath with a concentration of 95% and a temperature of 4°C for physical crosslinking for 8h. Finally, the hydrogel obtained by washing to neutrality has certain high light transmittance, high strength and high toughness, biodegradability and biocompatibility.

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PUM

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Abstract

The invention discloses the preparation and application of degradable, biocompatible and high-strength chitin hydrogel. The preparation method is as follows: add the cross-linking agent dropwise into the chitin solution with a concentration of 5-7% at -10-10°C and stir for 1-2 hours, then use the tape casting method to prepare the gel, and then put it in at a temperature of -10-10°C. °C, the concentration is 80-100% in a coagulation bath for 6-8 hours of physical cross-linking, and finally washed with water to obtain chitin hydrogel. The hydrogel prepared by the invention is degradable, has good biocompatibility and high mechanical strength. The hydrogel prepared by the invention has great potential in biomedical applications such as bone injury repair, abdominal adhesion prevention, drug delivery and the like.

Description

technical field [0001] The invention designs a preparation method and application of chitin hydrogel, belonging to the field of polymer functional materials. Background technique [0002] Chitin is a natural polysaccharide second only to cellulose in nature and widely exists in various marine organisms. It is of great significance to convert the abundant marine debris into various materials with excellent properties. Alkali / urea system is a green dissolution system, which converts insoluble chitin into homogeneous chitin aqueous solution, and then can prepare a series of materials with different forms and different properties. Chitin has hydrophilicity, biodegradability and good biocompatibility, and is an ideal material for preparing hydrogels for biomedical applications. Chitin hydrogels are three-dimensional cross-linked network structures containing a large amount of water, and are widely used in target In terms of drug loading, tissue engineering, wound dressing, etc....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08K5/544C08K5/5435A61K47/36A61L27/20A61L27/50A61L27/52A61L27/54A61L27/56A61P19/08A61P41/00
CPCC08J3/075C08J3/24A61K47/36A61P19/08A61P41/00A61L27/20A61L27/52A61L27/56A61L27/50A61L27/54C08J2305/08C08K5/544C08K5/5435A61L2430/02A61L2300/412C08L5/08
Inventor 叶啟发陈彪吴双泉
Owner WUHAN UNIV
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