Method for modifying polydimethylsiloxane material

Abstract

The invention discloses a method for modifying a polydimethylsiloxane material. The method comprises the following steps of: carrying out selective oxidation on carbohydrate containing carboxyl through sodium periodate to obtain oxidized carbohydrate containing active aldehyde groups; grafting dopamine onto the oxidized carbohydrate through amidation reaction by utilizing the reaction of amino andcarboxyl, thereby obtaining carbohydrate containing a catechol structure and an active aldehyde group; then pretreating a polydimethylsiloxane material to expose oxygen-containing groups on the surface of the polydimethylsiloxane material; and connecting bioactive collagen to the surface of the polydimethylsiloxane material by taking oxidized polysaccharide containing the catechol structure as abridge, so as to perform surface functional modification on the polydimethylsiloxane material, thereby obtaining the polydimethylsiloxane material with good and non-temporary hydrophilicity and excellent biocompatibility. Thus, a new way is opened up for preparation of a new generation of biocompatible and hydrophilic polydimethylsiloxane material. The method can be used for preparing biomedical materials.

Description

technical field

[0001] The invention relates to a method for modifying polydimethylsiloxane materials, belonging to the field of biomedical materials. Background technique

[0002] Silicone elastomers are currently one of the most widely used biomedical materials. A large number of clinical applications and animal experiments at home and abroad show that silicone elastomers have good physical and chemical stability and tissue compatibility. As an important member of silicone elastomers, poly(dimethylsiloxane), PDMS has a series of excellent properties such as high transparency, good air permeability, physiological inertness and good biocompatibility. It is widely used in biomedical fields such as plastic surgery, artificial organs, medical devices, drug sustained release, etc., and PDMS is easy to manufacture, low in cost, and has strong practical scalability. The main chain of PDMS is composed of -Si-O- alternately, and the side chain is composed of two organic groups att...