Method for modifying polydimethylsiloxane material

A polydimethylsiloxane, modified technology, applied in the field of biomedical materials, can solve the problems of lack of chemical activity, achieve low cytotoxicity, good biocompatibility, and promote the effect of cell growth and proliferation

Active Publication Date: 2021-03-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, these biomacromolecules lack enough chemically active groups to directly react with PDMS under mild conditions, and modify them

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027](1) Preparation of oxidized sodium alginate: Weigh 10 Kg of sodium alginate, add 100 L of absolute ethanol into a reaction kettle with a stirring device, start stirring, so that sodium alginate is evenly dispersed in ethanol, Then weigh 8Kg of sodium periodate and dissolve it in 100 L of distilled water in the dark, then add it to the ethanol dispersion of sodium alginate, stir and react for 6 h in the dark, then add ethylene glycol equivalent to sodium periodate to terminate React for 2 h. After the reaction, the reaction solution was introduced into a dialysis bag with a molecular weight cut-off of 3500 Da, and dialyzed with distilled water for 3 days, and the distilled water was changed 5 times a day. Freeze-dried with a freeze dryer and stored for subsequent use;

[0028] (2) Preparation of catechol-containing oxidized sodium alginate: Weigh 2.0 Kg of oxidized sodium alginate and dissolve it in 100L of MES buffer solution (50 mmol / L, pH=6.0), add 1Kg of NHS to the r...

Embodiment 2

[0032] (1) Oxidation of carboxymethyl chitosan: Weigh 500g of carboxymethyl chitosan, add it into a reaction kettle with 2.5L of absolute ethanol, start stirring to make it evenly dispersed in ethanol, and then weigh Take a certain quality of sodium periodate and dissolve it in 2.5 L of distilled water in the dark, then add it to the ethanol dispersion of carboxymethyl chitosan, stir it with magnetic force for 10 h in the dark, and then add the same molar amount of sodium periodate. Ethylene glycol terminated the reaction for 2 h. After the reaction was finished, the reaction solution was taken out, put into a dialysis bag with a molecular weight cut-off of 5000 Da, and dialyzed with distilled water for 3 days, changing the distilled water 5 times a day. Freeze-dried with a freeze dryer and stored for subsequent use;

[0033] (2) Preparation of oxidized carboxymethyl chitosan containing catechol structure: In the reaction kettle, add 500g oxidized carboxymethyl chitosan, 30L ...

Embodiment 3

[0037] (1) Preparation of oxidized hyaluronic acid: Disperse and dissolve 20g of hyaluronic acid and 4g of sodium periodate in ethanol and distilled water respectively, then mix the two, react in the cradle for 20h in the dark, and dissolve in ethylene glycol The reaction was terminated for 2 hours under the action of 3500Da dialysis bag, and the reactant was dialyzed with distilled water, and the solution was changed 5 times a day for 5 days;

[0038] (2) Preparation of oxidized hyaluronic acid containing catechol structure: Weigh 20g of oxidized hyaluronic acid and dissolve it in 50mmol / L, pH6 MES buffer solution, under the protection of nitrogen, mix with a certain amount of EDC, NHS After reacting for 1 hour, add 40 g of dopamine. After the pH is adjusted to 5.5, react in a cradle for 24 hours at 25 ° C. After the reaction, use a 3500 Da dialysis bag to dialyze in distilled water for 5 days, and change the solution 5 times a day;

[0039] (3) PDMS pretreatment: A plasma re...

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PUM

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Abstract

The invention discloses a method for modifying a polydimethylsiloxane material. The method comprises the following steps of: carrying out selective oxidation on carbohydrate containing carboxyl through sodium periodate to obtain oxidized carbohydrate containing active aldehyde groups; grafting dopamine onto the oxidized carbohydrate through amidation reaction by utilizing the reaction of amino andcarboxyl, thereby obtaining carbohydrate containing a catechol structure and an active aldehyde group; then pretreating a polydimethylsiloxane material to expose oxygen-containing groups on the surface of the polydimethylsiloxane material; and connecting bioactive collagen to the surface of the polydimethylsiloxane material by taking oxidized polysaccharide containing the catechol structure as abridge, so as to perform surface functional modification on the polydimethylsiloxane material, thereby obtaining the polydimethylsiloxane material with good and non-temporary hydrophilicity and excellent biocompatibility. Thus, a new way is opened up for preparation of a new generation of biocompatible and hydrophilic polydimethylsiloxane material. The method can be used for preparing biomedical materials.

Description

technical field [0001] The invention relates to a method for modifying polydimethylsiloxane materials, belonging to the field of biomedical materials. Background technique [0002] Silicone elastomers are currently one of the most widely used biomedical materials. A large number of clinical applications and animal experiments at home and abroad show that silicone elastomers have good physical and chemical stability and tissue compatibility. As an important member of silicone elastomers, poly(dimethylsiloxane), PDMS has a series of excellent properties such as high transparency, good air permeability, physiological inertness and good biocompatibility. It is widely used in biomedical fields such as plastic surgery, artificial organs, medical devices, drug sustained release, etc., and PDMS is easy to manufacture, low in cost, and has strong practical scalability. The main chain of PDMS is composed of -Si-O- alternately, and the side chain is composed of two organic groups att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L83/04
CPCC08J7/12C08J7/123C08J2383/04
Inventor 但卫华陈一宁但年华郑欣
Owner SICHUAN UNIV
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