Preparation method of sulfadoxine

A technology of sulfadoxine and sulfadoxine sodium, which is applied in the field of preparation of sulfadoxine, can solve problems such as complex processes and quality, and achieve the effects of simple process operation, high yield and no production equipment.
CN112457259APending Publication Date: 2021-03-09CHONGQING KANGLE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING KANGLE PHARMA
Publication Date
2021-03-09

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Abstract

The invention provides a preparation method of sulfadoxine. The method is a preparation method of sulfadimethoxine, and the sulfadimethoxine product is prepared by directly taking 4-chloro-5, 6-dimethoxypyrimidine and sodium sulfanilamide as raw materials through a condensation reaction. The method is simple in process, free of special requirements on equipment, simple and convenient to operate, good in product quality and suitable for industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of preparation of sulfonamide antibacterial drugs, and in particular relates to a preparation method of sulfadoxine. Background technique

[0002] Sulfadoxine, also known as sulfadoxine, English name: Sulfadoxine, chemical name: 4-(p-aminobenzenesulfonylamino)-5,6-dimethoxypyrimidine, CAS registration number: 2447-57- 6.

[0003] The chemical structural formula is as follows:

[0004]

[0005] Sulfadoxine is a sulfonamide antibiotic. Sulfadoxine has the characteristics of long curative effect and low toxicity, and can treat general inflammations, such as upper respiratory tract infection pancreatitis, bacillary dysentery enteritis and skin infections, and has certain curative effect on the treatment of tuberculosis, lymphatic tuberculosis, etc. with other medicine compatibility. Can treat malaria. In addition, sulfadoxine can also be used as a preventive drug for rheumatic venereal diseases.

[0006] ...

Claims

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