Composition comprising vegetable extracts with flavonoids for alleviating the many effects of air pollution on the skin

A technology of air pollution and composition, which is applied in the field of products for treating human skin lesions, and can solve problems such as cost

Pending Publication Date: 2021-03-16
MONTELOEDER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of all these products to alleviate the effects of ambient air pollution on the skin implies considerable expense and, if the product combination has not been tested previously, the parallel or simultaneous application of several preparations on the skin, with the attendant risk of unwanted effects. related risks

Method used

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  • Composition comprising vegetable extracts with flavonoids for alleviating the many effects of air pollution on the skin
  • Composition comprising vegetable extracts with flavonoids for alleviating the many effects of air pollution on the skin
  • Composition comprising vegetable extracts with flavonoids for alleviating the many effects of air pollution on the skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Example 1. Study on antioxidant, anti-inflammatory and whitening effects of extract compositions with high flavonoid content.

[0125]

[0126]

[0127]

[0128] Table 1 Composition of the three compositions tested in Example 1.

[0129] Preliminary assays have been carried out to determine the mitigating activity of different compositions on the effects of air pollution on the skin, taking into account that oxidative and inflammatory processes are important in the generation of pollution-induced skin damage.

[0130] Furthermore, since air pollution increases the appearance of skin pigmentation and spots, studies have been done on the ability of several compositions to inhibit melanin production.

[0131] Table 1 shows the ingredients and their concentrations in each composition tested in the preliminary study. Table 1 summarizes the composition of the three tested compositions and shows the mg of flavonoids per 100 mg of product or the final amount of each e...

Embodiment 2

[0198] Example 2. In vitro study of antioxidant and cytoprotective activity of Composition IB against the effects of UV radiation and urban particulate matter on human keratinocytes.

[0199] Living organisms are exposed to air pollutants, which have important effects on human skin. Ait pollutants are solids, liquids, gases and particulate matter (PM). They are absorbed directly into the skin until they reach the subcutaneous tissue or through hair follicles or sweat / sebocytes. Rapid urbanization and huge increases in energy consumption worldwide expose humans to ever-increasing ambient air pollution. The skin constitutes the largest and outermost organ of the body, serving as a physical, chemical and immune barrier against these environmental factors.

[0200]Air pollutants have deleterious effects on the skin by increasing oxidative stress against the skin's antioxidant defenses. Generates free radicals and generates reactive oxygen species that interact with lipid-rich p...

Embodiment 3

[0211] Example 3. Ex vivo evaluation of the anti-air pollution activity of Composition 1B (Zero Pollution) in live human skin explants.

[0212] The aim of this study was to evaluate the anti-air pollution activity of Composition 1B in Table 1 on live human skin explants after treatment with a mixture of pollutants. After explants were treated ex vivo with composition 1B (zero pollution) and solutions of heavy metals, hydrocarbons and diesel particles, the anti-air pollution activity was evaluated by the following methods: malondialdehyde biochemical assay, aryl hydrocarbon (AhR) receptor immunoassay, metal Thionin MT-1H immunoassay, interleukin-1-alpha (IL-1a) biochemical quantitative assay.

[0213] In a 56-year-old Caucasian female, 19 human skin explants with a mean diameter of 12 mm were obtained by abdominoplasty. The explants were kept alive in culture medium (BIO-EC explant medium) under suitable atmosphere, temperature and humidity conditions.

[0214] The explants ...

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Abstract

The invention relates to a composition for use in the treatment of the effects of environmental pollution on the skin or for the prevention of premature ageing of the skin associated with the effectsof environmental pollution. Said composition comprises diterpenes, oleuropein, verbascoside, quercetin and hydroxytyrosol. In a preferred embodiment, the composition contains approx. 32 wt.% of rosemary extract with a minimum content of 15 wt.% of diterpenes, approx. 30 wt.% of olive leaf or fruit extract with a minimum content of 16 wt.% of oleuropein and a minimum content of 5 wt.% of hydroxytyrosol, approx. 28 wt.% of Lippia citriodora extract with a minimum content of 25 wt.% of verbascoside, and approx. 10 wt.% of Sophora japonica extract with a minimum content of 40 wt.% of quercetin.

Description

technical field [0001] The invention belongs to the technical field of products for treating human skin lesions, in particular, the product is used to alleviate the multiple effects of urban air pollution on the skin. However, the compositions of the present invention (when specially formulated to mitigate the effects of multiple urban environmental pollution) can also be commercialized and used with different indications to provide significant relief, such as skin due to cellular aging Degradation delay product. Background technique [0002] Long-term exposure to urban air pollution can simultaneously cause multiple harmful effects on human skin. These harmful effects include premature skin aging, allergic or inflammatory conditions such as the appearance of atopic skin, dermatitis, eczema, psoriasis or acne, and even skin cancer, as well as more serious lesions where pollution can induce skin cancer )(1). [0003] In recent years, numerous scientific studies have demons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q17/00A61Q19/00A61Q19/02A61Q19/08A61K36/85A61P17/00A23L33/105
CPCA61P37/06A61P17/00A61P39/06A61K36/489A61K36/53A61K36/63A61K36/85A61K31/7032A61K31/352A61K31/7048A61K31/05A61K45/06A61K31/192A61K8/498A61K8/602A61K8/347A61K8/31A61Q19/08A61K2300/00A61Q17/00A61Q19/00A61K8/9789A61K31/01A61K36/48A23L33/105A61K2800/5922A23V2002/00A23V2200/318A23L33/40A61K31/353A61K31/7034A61K2800/28A61K2800/92A61Q17/04A61Q19/007A61Q19/008A61Q19/10
Inventor N·卡塔拉·塞努达A·佩拉尔·克莱门特
Owner MONTELOEDER
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