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Nano treatment structure and preparation method thereof

A nanotechnology, therapeutic drug, applied in the fields of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of tumor hypoxia, reduce nanoplatform, tumor angiogenesis, etc., and achieve high clinical therapeutic benefit and efficient removal effect.

Active Publication Date: 2021-03-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this drug has the following defects: (1) Medical nano scintillators that play the role of energy conversion are often inefficient, have large toxic and side effects, and cannot exist stably for a long time in physiological environments and retain their optical properties; (2) Nano scintillators The low energy transfer efficiency between the body and the photosensitizer severely restricts the generation of reactive oxygen species, and ultimately reduces the therapeutic effect of the nanoplatform on cancer; (3) X-ray-induced photodynamic therapy will consume oxygen in the tumor microenvironment, resulting in the Tumors in a hypoxic state are extremely hypoxic, which in turn induces a series of adverse prognosis events such as tumor angiogenesis, invasion, and metastasis; (4) Due to the aforementioned limitations, X-ray-induced photodynamic therapy currently reported requires the use of more Large radiation doses to produce sufficient therapeutic effect
On the one hand, the development of new nano scintillators, but the efficiency and biosafety of nano scintillators have not been given sufficient attention; Rational setup of multiple components on nanoplatforms is often overlooked

Method used

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  • Nano treatment structure and preparation method thereof
  • Nano treatment structure and preparation method thereof
  • Nano treatment structure and preparation method thereof

Examples

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Embodiment 1

[0050] Example 1: X-ray photodynamic therapy + chemotherapy

[0051] Lu of the embodiment of the present invention 2 o 3 :Tb 3+ The construction of the nano-scintillation dual-core-satellite nanoplatform includes the following steps: Step S1, synthesis of surface carboxyl-modified CaF 2 :Tb 3+ Nano scintillator; step S2, grafting polyethylene glycol on the surface of the dendrimer, and then modifying the surface of the nano scintillator; step S3, connecting the photosensitizer Rose Bengal to the surface of the dendrimer; step S4, adding The chemotherapy drug doxorubicin is loaded inside the dendrimer.

[0052] Specifically, the above step S1 includes:

[0053] Step S11: Weigh 0.5 mmol of lutetium acetylacetonate and 0.05 mmol of terbium acetylacetonate into a 50 mL flask, add 15 mL of oleic acid and 5 mL of oleylamine, and stir at 90° C. for 10 min.

[0054] Step S12: heating to 120° C., and vacuuming for 30 minutes.

[0055] Step S13: blow nitrogen, heat to 280° C., an...

Embodiment 2

[0072] Example 2: X-ray photodynamic therapy + anti-angiogenesis therapy

[0073] The CaF of the embodiment of the present invention 2 :Tb 3+ The construction of the nano-scintillation dual-core-satellite nanoplatform includes the following steps: Step P1: Synthesis of surface carboxyl-modified CaF 2 :Tb 3+ Nano-scintillator; Step P2: Carry out surface polyethylene glycol grafting on the dendrimer, and then modify the surface of the nano-scintillator; Step P3: Connect the photosensitizer Rose Bengal to the surface of the dendrimer; Step P4: Apply the anti- The angiogenic drug Sunitinib loaded into dendrimers.

[0074] Specifically, the above step P1 includes:

[0075] Step P11: Weigh 0.5mmol of calcium chloride, 0.05mmol of terbium chloride, and 0.5mmol of sodium citrate, dissolve them in 25mL of deionized water, and stir thoroughly for 30 minutes to form a stable combination of citrate and metal cations.

[0076] Step P12: Weigh 3.0 mmol of ammonium fluoride, dissolve it...

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Abstract

The invention provides a nano treatment structure and a preparation method thereof. The structure comprises a nanometer scintillator, the surface of the nanometer scintillator is modified with a dendrimer, the surface of the dendrimer is grafted with a photosensitizer, and the dendrimer is internally provided with a cavity for loading a treatment drug. The nano treatment structure has the capability of multiple drug loading, and can be used as a universal template to build a cooperative treatment platform for X-ray photodynamic therapy and other therapies, such as X-ray photodynamic therapy+radiotherapy, X-ray photodynamic therapy+chemotherapy, X-ray photodynamic therapy+immunotherapy, X-ray photodynamic therapy+anti-angiogenesis treatment, and X-ray photodynamic therapy+anti-angiogenesistreatment, and the structure has extremely high clinical treatment benefits, and can realize efficient removal of deep tumors under a low-dose condition.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a nanotherapy structure and a preparation method thereof. Background technique [0002] Developing effective treatments to combat cancer remains one of the top priorities of modern clinical medicine. X-ray-induced photodynamic therapy uses nano scintillators to convert X-rays into ultraviolet or visible light, then excites photosensitizers and triggers the generation of reactive oxygen species, which can kill cancer cells. Due to the extremely high penetration depth of X-rays in biological tissues, X-ray-induced photodynamic therapy has great potential for the treatment of deep cancers. [0003] After searching the prior art, the application number is: CN201780031000.X, which discloses a prodrug of a lipid moiety linked to a drug derivative such as an anticancer drug derivative through a linker containing a disulfide group, and a prodrug coated with Nanoparticles comprisi...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K45/00A61K47/58A61K47/59A61K47/61A61K47/64A61P35/00B82Y5/00
CPCA61K41/0057A61K45/00A61K47/595A61K47/58A61K47/64A61K47/61A61P35/00B82Y5/00A61K2300/00
Inventor 李万万姜朝
Owner SHANGHAI JIAO TONG UNIV