Quaternary ammonium salt cationic antibacterial and antifouling coating layer as well as preparation method and application thereof

A quaternary ammonium salt cation, antifouling coating technology, applied in antifouling/underwater coatings, coatings, polyether coatings, etc., can solve problems such as limited application, achieve excellent bacteriostatic effect, good cytocompatibility , the effect of inhibiting the initial contact of bacteria

Active Publication Date: 2021-03-26
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, external stimuli are difficult to apply

Method used

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  • Quaternary ammonium salt cationic antibacterial and antifouling coating layer as well as preparation method and application thereof
  • Quaternary ammonium salt cationic antibacterial and antifouling coating layer as well as preparation method and application thereof
  • Quaternary ammonium salt cationic antibacterial and antifouling coating layer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0047] Raw materials used in Examples 1 to 3 of the present invention and their consumption are shown in Table 1 below:

[0048] Table 1

[0049]

[0050] In a 100mL round bottom flask, according to the proportion shown in Table 1, add solvent DMF, initiator AIBN, monomer MAEBA, monomer QA8C, monomer EHA successively, pass N 2 After deoxygenation, it was vacuum-sealed and placed in an oil bath at 65°C for 24 hours with magnetic stirring. After the reaction was completed, it was cooled to room temperature, and anhydrous diethyl ether was used as a precipitating agent, and the purification was repeated 3 times. Finally vacuum-dry to constant weight, obtain the quaternary ammonium salt cationic polymer of embodiment 1~3, denote respectively as 8C-PMQE-CHO-30, 8C-PMQE-CHO-40, 8C-PMQE-CHO-45. Such as figure 1 Shown is the quaternary ammonium salt cationic polymer 8C-PMQE-CHO-30, 8C-PMQE-CHO-40, 8C-PMQE-CHO-45 of embodiment 1~3 1 In the H NMR spectrogram, in the figure, the h...

Embodiment 4

[0052] Preparation of quaternary ammonium salt cationic antibacterial and antifouling coating sample SS-8C-PMQE-PEG-30 and its Schiff base fracture coating sample SS-8C-PMQE on the surface of medical stainless steel 316L substrate (SS) by dip coating -RE-30, the specific preparation steps are as follows:

[0053] Dissolve the quaternary ammonium salt cationic polymer 8C-PMQE-CHO-30 prepared in Example 1 in the solvent dichloromethane, and mix uniformly to obtain a 5 mg / mL coating solution for use; then use 400 mesh and 1000 Purpose: Grind the oxide layer on the surface of medical stainless steel 316L base material (SS) with sandpaper, wash and dry the surface with acetone and ethanol, soak in the above coating solution for 1min, take it out and dry it at room temperature, and repeat the soaking and drying three times to obtain the quaternary ammonium salt cationic polymer coating sample SS-8C-PMQE-CHO-30;

[0054] The above-mentioned quaternary ammonium salt cationic polymer ...

Embodiment 5

[0057] Preparation of quaternary ammonium salt cationic antibacterial and antifouling coating sample SS-8C-PMQE-PEG-40 and its Schiff base fracture coating sample SS-8C-PMQE on the surface of medical stainless steel 316L substrate (SS) by dip coating -RE-40, its preparation steps are the same as embodiment 4, the difference is only: embodiment 5 adopts the quaternary ammonium salt cationic polymer 8C-PMQE-CHO-40 that the embodiment 2 makes to replace the quaternary ammonium salt that the embodiment 1 makes Ammonium salt cationic polymer 8C-PMQE-CHO-30 participated in the reaction to obtain quaternary ammonium salt cationic polymer coating sample SS-8C-PMQE-CHO-40, and then obtained quaternary ammonium salt cationic antibacterial and antifouling coating sample SS-8C - PMQE-PEG-40 coating sample and Schiff base fracture coating sample SS-8C-PMQE-RE-40.

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Abstract

The invention discloses a quaternary ammonium salt cationic antibacterial and antifouling coating layer as well as a preparation method and application thereof. The quaternary ammonium salt cation antibacterial and antifouling coating layer is arranged on the surface of a base material and comprises an outer-layer polyethylene glycol structure and an inner-layer quaternary ammonium salt cationic polymer structure; the polyethylene glycol structure and the quaternary ammonium salt cationic polymer structure are combined together through a Schiff base structure to form a polymer brush with a layered structure. Therefore, under the condition of normal or slight infection, the outer-layer polyethylene glycol structure can effectively inhibit adhesion of bacteria, and when serious infection occurs, the bacteria can secrete acidic substances to cause Schiff base breakage, so that the inner-layer quaternary ammonium salt cationic polymer structure is exposed to kill the bacteria and inhibit infection. The preparation method of the quaternary ammonium salt cationic antibacterial and antifouling coating layer is simple and safe, the solution stability is good, and the quaternary ammonium salt cationic antibacterial and antifouling coating layer has a long-acting antibacterial antifouling function and can be widely applied to the fields of bioengineering and biomedicine.

Description

technical field [0001] The invention relates to a quaternary ammonium salt cationic antibacterial antifouling coating and a preparation method and application thereof, belonging to the technical field of antibacterial coatings. Background technique [0002] Medical equipment, diagnostic equipment, and implants are widely used clinically due to their superior comprehensive performance. However, since most implant materials are biologically inert, their implant safety is seriously threatened by implant-related infections. For these implant materials, initial bacterial attachment and subsequent bacterial colonization is the main cause of infection, which not only limits the service life of the implanted device, but may also lead to serious complications and even death. Therefore, it is crucial to improve the antibacterial properties of implant materials. [0003] In recent years, quaternary ammonium salt cationic polymers have attracted great attention of researchers due to th...

Claims

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Application Information

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IPC IPC(8): C09D133/10C09D133/14C09D5/16C09D5/14C09D171/02C08F220/18C08F220/34C08F220/30B05D5/00B05D7/14B05D7/24
CPCC09D133/14C09D5/1662C09D5/14C09D171/02C08F220/302C08F220/1808B05D5/00B05D7/14B05D7/24B05D7/54B05D2202/15C08F220/34
Inventor 李小杰罗静朱叶
Owner JIANGNAN UNIV
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