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Aluminum sulfate compound injection as well as preparation method and application thereof

A compound injection and aluminum sulfate technology, applied in the field of medicine, can solve the problems of injection stability and safety, treatment effect needs to be improved, large dosage, etc., to achieve improved effect and safety, obvious synergistic effect, and low cost Effect

Inactive Publication Date: 2021-03-30
NKD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent application 200410033644.7 discloses an aluminum sulfate injection for the treatment of bladder tumors and its preparation method, in which lidocaine hydrochloride exerts local anesthesia and analgesia, and methylene blue facilitates local injection positioning, and the injection can inhibit tumors to a certain extent growth, but the therapeutic effect still needs to be improved
In addition, the prior art also discloses the scheme of aluminum sulfate in the treatment of various tumors (thyroid cancer, ovarian cancer, bladder cancer, lung cancer, liver cancer, prostate cancer, breast cancer, colon cancer, cardia cancer, rectal cancer, gastric cancer), but The content of aluminum sulfate in its injection is as high as 300mg / ml, the dosage is large, and the stability and safety of the injection need to be improved

Method used

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  • Aluminum sulfate compound injection as well as preparation method and application thereof
  • Aluminum sulfate compound injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare aluminum sulfate compound injection of the present invention, concrete steps are as follows:

[0041] (1) At room temperature, add 155.69 g of aluminum sulfate octadecahydrate, 10 g of lidocaine hydrochloride, and 0.05 g of methylene blue to 400 ml of water for injection, stir and dissolve to obtain a mixed solution;

[0042] (2) Filter the mixed solution through a 0.22 μm membrane filter;

[0043] (3) Add 333ml of 12mol / L concentrated hydrochloric acid, then add an appropriate amount of water for injection to make the volume to 1000ml, stir and mix evenly;

[0044] (4) Filling, sealing, and ready to serve.

Embodiment 2

[0046] Prepare aluminum sulfate compound injection of the present invention, concrete steps are as follows:

[0047] (1) At room temperature, add 116.77g of aluminum sulfate octadecahydrate, 30g of lidocaine hydrochloride, and 0.02g of methylene blue to 500ml of water for injection respectively, stir and dissolve to obtain a mixed solution;

[0048] (2) Filter the mixed solution through a 0.22 μm membrane filter;

[0049] (3) Add 167ml of 12mol / L concentrated hydrochloric acid, then add an appropriate amount of water for injection to make the volume to 1000ml, stir and mix evenly;

[0050](4) Filling, sealing, and ready to serve.

experiment example 1

[0061] In this experiment, the injections prepared in Example 1-2 and Comparative Example 1-2 were tested for liver tissue processing. The specific test results are as follows:

[0062] Thirty SD rats were randomly divided into 5 groups, namely, Comparative Example 1 Group, Comparative Example 2 Group, Example 1 Group, Example 2 Group and a normal saline control group. Weigh, inject 10% chloral hydrate into the abdominal cavity according to 0.3ml / 100g for anesthesia, prepare the abdominal skin, disinfect, incise the abdominal wall, expose the liver, inject 0.05ml of the corresponding group's injection into the liver of each group, and inject the control group Normal temperature saline 0.05ml, the abdomen was closed, and sutured. After 72 hours of ablation, they were sacrificed, and the livers were taken out, and all sections were prepared for HE staining, and the pathological changes were observed with a light microscope.

[0063] First, everything in the normal saline contr...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses an aluminum sulfate compound injection as well as a preparation method and application thereof. The aluminum sulfate compound injection comprises inorganic acid and aluminum sulfate, wherein the molar ratio of hydrogen ions provided by the inorganic acid to the aluminum sulfate is (10-20):1. In the aluminum sulfate compound injection, the synergistic effect of aluminum sulfate and inorganic acid is obvious, the tumor treatment effect is good, the effect taking speed is high, toxic and side effects are small,use is safe, and indications are wide. The method for preparing the aluminum sulfate compound injection does not need moist heat sterilization, is simple and convenient to operate and is suitable forindustrial popularization. The invention also provides an application of the aluminum sulfate compound injection or the preparation method of the aluminum sulfate compound injection in an anti-tumor preparation, tumors comprise but are not limited to solid tumors such as a digestive system, a respiratory system, a urinary system, a reproductive system and the like, and the field of minimally invasive interventional therapy of tumors is expanded.

Description

technical field [0001] The invention relates to the technical field of medicine. Specifically, it relates to an aluminum sulfate compound injection and its preparation method and application. Background technique [0002] Interventional therapy is a minimally invasive treatment using modern high-tech technology. Under the guidance of medical imaging equipment, special catheters / guide wires and other precision instruments are introduced into the human body to diagnose and locally treat lesions in the body. Its biggest feature is that it can treat many difficult diseases by passing the thin tube through the incision (puncture point) the size of a rice grain without surgery. It has the characteristics of no surgery, small trauma, quick recovery and good effect. At present, interventional therapy has become one of the main means of clinical treatment of tumors in modern hospitals. [0003] Aluminum ions have astringent effect and can be combined with protein to coagulate and p...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K45/06A61K33/06A61K33/20A61K47/22A61P35/00A61P23/02A61K31/167
CPCA61K9/0019A61K9/08A61K31/167A61K33/06A61K33/20A61K45/06A61K47/22A61P23/02A61P35/00A61K2300/00
Inventor 张志兵左保燕陶秀梅陈鹏尚丽霞
Owner NKD PHARMA CO LTD
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