Rare earth-based nano composite hydrogel wound dressing as well as preparation method and application thereof

A nano-composite, hydrogel technology, applied in pharmaceutical formulations, medical science, bandages, etc., can solve the problems of unreported wound healing and tissue regeneration, achieve good biological effects, accelerate wound healing, and the preparation method is simple Effect

Active Publication Date: 2021-04-06
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the research of rare earth-based nanocomposite hydrogel dressings for wound healing and tissue regeneration has not been reported

Method used

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  • Rare earth-based nano composite hydrogel wound dressing as well as preparation method and application thereof
  • Rare earth-based nano composite hydrogel wound dressing as well as preparation method and application thereof
  • Rare earth-based nano composite hydrogel wound dressing as well as preparation method and application thereof

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preparation example Construction

[0034] A preparation method of europium oxide-based nanocomposite hydrogel wound dressing of the present invention comprises the following steps:

[0035] 1) First use the hydrothermal reaction to prepare europium hydroxide nanorods, first add europium nitrate to deionized water, stir and dissolve at room temperature, then adjust the pH to 8-9 with 1M sodium hydroxide, and then continue to stir at room temperature for 30-60 minutes, and then put it into an oven at 120-200°C for 12-48 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Europium hydroxide was calcined at 600°C for 3-5 hours to obtain europium oxide nanorods, which were stored in a vacuum desiccator for further use.

[0036] 2) Dissolve sodium hyaluronate in MES buffer (pH=5-6) and stir to dissolve, activate with NHS and EDC, after 10-14 hours, add sodium alendronate and continue stirring for 2-3 days, wherein The molar rati...

Embodiment 1

[0045] 1) The preparation method of europium oxide nanorods: first add europium nitrate into deionized water, stir and dissolve at room temperature, then adjust the pH to 8-9 with 1M sodium hydroxide, then continue to stir at room temperature for 30-60 minutes, and then put it into an oven React at 120°C for 12 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Calcining europium hydroxide at 600°C for 4 hours to obtain europium oxide nanorods, which were stored in a vacuum desiccator for further use;

[0046]2) Preparation method of HA-AL polymer: dissolve 1mmol sodium hyaluronate in MES buffer (pH=5~6) and stir to dissolve, activate with NHS and EDC, after 12 hours, add 3mmol into alendronate Sodium acid continued to stir for 2 to 3 days; finally, 2 to 3 purifications were performed on the hyaluronic acid-alendronate sodium polymer (HA-AL) obtained by the reaction with a dialysis tube (...

Embodiment 2

[0056] 1) The preparation method of terbium oxide nanorods: first add terbium nitrate into deionized water, stir and dissolve at room temperature, then adjust the pH to 8-9 with 1M sodium hydroxide, then continue stirring at room temperature for 30-60 minutes, and then put Reaction in an oven at 200°C for 16 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Calcining terbium hydroxide at 600°C for 3 hours to obtain terbium oxide nanorods, which were stored in a vacuum desiccator for further use;

[0057] 2) Preparation method of HA-AL polymer: dissolve 1mmol sodium hyaluronate in MES buffer (pH=5-6) and stir to dissolve, activate with NHS and EDC, after 12 hours, add 4mmol alendronic acid The sodium continued to stir for 2-3 days; finally, 2-3 purifications were performed on the hyaluronic acid-alendronate sodium polymer (HA-AL) obtained by the reaction with a dialysis tube (10 kDa). HA...

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Abstract

The invention provides a rare earth-based nano composite hydrogel wound dressing as well as a preparation method and an application thereof. The preparation method comprises the following steps: preparing rare earth oxide nanorods through annealing treatment by utilizing a hydrothermal reaction; dissolving sodium hyaluronate in an MES buffer solution, activating with NHS and EDC, and finally adding alendronate sodium for a reaction; reacting to obtain a hyaluronic acid-alendronate sodium polymer; dispersing the hyaluronic acid-alendronate sodium polymer into a PBS buffer solution of F127, and after the hyaluronic acid-alendronate sodium polymer is completely dispersed, adding rare earth oxide nanorods to form nano-composite hydrogel, thereby obtaining the rare earth-based nano-composite hydrogel wound dressing. The rare earth-based nano composite hydrogel wound dressing also shows good biocompatibility in vivo and in vitro, and also has good anti-inflammatory property, so that the hydrogel dressing has good application prospects in wound healing and tissue regeneration.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a rare earth-based nanocomposite hydrogel wound dressing and a preparation method and application thereof. Background technique [0002] The development of highly bioactive wound dressings that can accelerate wound healing and skin regeneration is the key to clinical wound reconstruction. Currently, various biomaterials have been used, such as inorganic biomaterials, organic biomaterials, and organic-inorganic hybrid biomaterials. Inorganic biomaterials such as silicon-based bioglass, silver nanoparticles, and zinc oxide nanorods have been demonstrated to have significant potential in wound healing and tissue regeneration. Rare-earth-based nanomaterials are widely used in various biomedicines, such as bioimaging, cancer diagnosis, and cancer therapy, due to their unique optical, magnetic, and catalytic properties, whereas they are rarely used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08B37/08
CPCA61L26/0023A61L26/0004A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L26/009C08B37/0072A61L2300/412A61L2400/12A61L2300/41A61L2300/236C08L5/08C08L71/02
Inventor 雷波罗梦
Owner XI AN JIAOTONG UNIV
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