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Tannic acid curcumin nanoparticles and preparation method and use thereof

A nanoparticle and tannic acid technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, non-effective ingredients of polymer compounds, etc., can solve problems such as toxicity, and achieve improvement of colitis, good adhesion, and particle size evenly distributed effect

Active Publication Date: 2021-04-09
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally, cross-linking agents such as glutaraldehyde are commonly used in protein-nanoparticles (NPs), which can improve the solubility of target drugs through cross-linking, but there are also potential toxicity problems caused by conventional cross-linking agents glutaraldehyde

Method used

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  • Tannic acid curcumin nanoparticles and preparation method and use thereof
  • Tannic acid curcumin nanoparticles and preparation method and use thereof
  • Tannic acid curcumin nanoparticles and preparation method and use thereof

Examples

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Embodiment 1

[0057] Embodiment 1, the preparation of tannic acid curcumin nanoparticles of the present invention

[0058] The present invention mainly adopts oil-in-water (O / W) single emulsion-solvent evaporation technology to prepare tannic acid curcumin nanoparticles (TA / CUR-NPs), and the specific method is as follows:

[0059] (1) Preparation of curcumin nanoparticles: 100mg human serum albumin (HSA) was dissolved in 50mL deionized water to prepare HSA solution; meanwhile, 20mg genipin (Gnp) and 5mg curcumin (CUR) were completely dissolved in 1mL of acetone to obtain the organic phase; the above two organic phases were dropped into the HSA solution under constant magnetic stirring; then the mixture was placed in an ice bath and ultrasonically treated with a probe sonicator at 70% amplitude power for 6 minutes. Forms an oil-in-water emulsion. The emulsion was further stirred at room temperature at 400 rpm for 6 hours to eliminate residual acetone. The emulsion was then introduced into ...

Embodiment 2

[0062] Embodiment 2, the preparation of emodin tannic acid nanoparticles of the present invention

[0063] The present invention mainly adopts oil-in-water (O / W) single emulsion-solvent evaporation technology to prepare emodin tannic acid nanoparticles (TA / EM-NPs), and the specific method is as follows:

[0064] (1) Preparation of emodin nanoparticles: 100 mg of human serum albumin (HSA) was dissolved in 50 mL of deionized water to prepare HSA solution; meanwhile, 20 mg of genipin (Gnp) and 10 mg of emodin (EM) were completely dissolved in 1mL of acetone to obtain the organic phase; the above two organic phases were dropped into the HSA solution under constant magnetic stirring; then the mixture was placed in an ice bath and ultrasonically treated with a probe sonicator at 70% amplitude power for 6 minutes. Forms an oil-in-water emulsion. The emulsion was further stirred at room temperature at 400 rpm for 6 hours to eliminate residual acetone. The emulsion was then introduce...

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Abstract

The invention provides tannic acid curcumin nanoparticles and a preparation method and use thereof, and belongs to the field of biomedical materials. The nanoparticles are prepared from the following raw materials in parts by weight: 80-100 parts of human serum albumin, 10-50 parts of genipin, 1-20 parts of a medicine and 10-50 parts of tannic acid. The medicine is preferably curcumin. The raw materials of the tannic acid drug-loaded nanoparticles are derived from food-grade materials and toxicity of the tannic acid drug-loaded nanoparticles is far lower than that of other synthesized chemical nano materials. The nanoparticles have good stability and high encapsulation efficiency and drug loading rate. More importantly, the nanoparticles have a targeting function on lesion colons, can be prevented from being destructively influenced by the stomach environment, and have an effect superior to that of other nano drug delivery systems reported before. Therefore, the tannic acid curcumin nanoparticles are a more promising oral administration system for treating colonic parts, especially ulcerative colitis.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a curcumin tannin nanoparticle, a preparation method and application thereof. Background technique [0002] Ulcerative colitis (UC) is a chronic, recurrent inflammatory disease. It is located in the distal bowel and mainly involves the rectal and colonic mucosa and submucosa. Ulcerative colitis incidence is highest in Europe and the United States; incidence has also recently increased sharply in Asia and low-income countries in recent years. First-line treatment of ulcerative colitis focuses on aminosalicylic acids, corticosteroids, and immunosuppressive drugs. However, these drugs have limited efficacy and can cause serious side effects, including diarrhea, osteoporosis, or infection. In view of this, there is a higher demand for finding better therapeutic regimens and screening natural bioactive compounds, which has become a promising alternative strategy. ...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K47/42A61K47/26A61K47/22A61K31/12A61P1/00A61P1/04A61K31/216A61K31/122A61K31/58
CPCA61K9/19A61K47/42A61K47/26A61K47/22A61K31/12A61P1/00A61P1/04A61K31/216A61K31/122A61K31/58
Inventor 高飞罗锐锋林美斯章津铭张晨石金凤陈其艳廖婉
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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