Pharmaceutical composition containing erigeron breviscapus extract and borneol and preparation method of pharmaceutical composition

A technology of scutellaria scutellaria and extracts, which is applied in the field of pharmaceutical preparations, can solve the problems of excessively fast release, low in vivo utilization, and failure to meet the requirements of sustained release, and achieve excellent stability

Active Publication Date: 2021-04-09
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 1) The extract of Erigeron breviscapus contains flavonoids, lactones, volatile oils, amino acids, etc., and has many active ingredients with complex polarity. After being prepared into preparations, the release of oral medicines is uncontrollable and usually releases quickly
[0010] 2) Common breviscapine preparations require long-term medication due to their low in vivo availability
[0011] 3) Ordinary scutellarin slow-release preparations currently adopt the pharmacopoeia method and contain less total caffeic acid esters. Experiments have found that if the slow-release preparations are prepared by mixing scutellarin + total caffeic acid, adding conventional slow-release excipients (such as hydroxy Propylmethylcellulose and lactose, etc.), the release rate is always too fast to meet the sustained release requirements

Method used

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  • Pharmaceutical composition containing erigeron breviscapus extract and borneol and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing erigeron breviscapus extract and borneol and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing erigeron breviscapus extract and borneol and preparation method of pharmaceutical composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Prescription 1

[0059] components effect prescription Erigeron extract API 100 ice flakes stabilizer 2 PVP K30 Adhesive 7 Calcium hydrogen phosphate (Hunan Jiudian Pharmaceutical Co., Ltd.) contains 5% NaHCO3 filler 20 HPMC K4M sustained release agent 30 Magnesium stearate (Shanghai Yunhong Chemical Preparations and Excipients Technology Co., Ltd.) lubricant 1 total 160

[0060] Preparation method: 1) Mix the raw material drug, binder, filler, and slow-release material evenly, add purified water (the amount is adjusted according to actual operation) for wet granulation, and dry in a fluidized bed until the LODfigure 1 , using the pH simulated release method to obtain an ideal S-type pH-dependent release curve. )

Embodiment 2

[0062] Prescription 2

[0063]

[0064]

[0065] Preparation method: 1) Mix the raw material drug, binder, filler, and slow-release material evenly, add purified water (the amount is adjusted according to actual operation) for wet granulation, and dry in a fluidized bed until the LOD<1.0%. After granulation by 1016μm Comil, add lubricant, mix evenly, and perform tablet compression, the theoretical tablet weight is 1000mg; tablet hardness is controlled at 150N.

Embodiment 3

[0067] Prescription 3

[0068] components effect prescription Erigeron extract API 100 ice flakes stabilizer 2 PVP K30 Adhesive 7 Dibasic calcium phosphate anhydrous (Hunan Jiudian Pharmaceutical Co., Ltd.) contains 5% KHCO3 filler 20 HPMC K15M sustained release agent 30 silica lubricant 1 total 160

[0069] Preparation method: 1) Mix the raw material drug, binder, filler, and slow-release material evenly, add purified water (the amount is adjusted according to actual operation) for wet granulation, and dry in a fluidized bed until the LOD<1.0%. After granulation by 1016μm Comil, add lubricant, mix evenly, and perform tablet compression, the theoretical tablet weight is 1000mg; tablet hardness is controlled at 150N.

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PUM

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Abstract

The invention relates to a pharmaceutical composition containing an erigeron breviscapus extract and borneol. The pharmaceutical composition is prepared from the erigeron breviscapus extract and auxiliary materials thereof, wherein the erigeron breviscapus extract is a mixture of extracts of scutellarin and total caffeic acid ester; the auxiliary materials contain the borneol, a slow-release material, a filling agent, a binding agent, a lubricating agent and an accelerator sodium bicarbonate or potassium bicarbonate; the borneol can be used for remarkably improving the stability of the product; and after the filling agent and the accelerator are added, the medicine can be smoothly subjected to pH-dependent release, so that the pharmaceutical composition has better medicine applicability.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing breviscapine extract and borneol, a preparation method and application thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Erigeron breviscapas vant Hand Mass, also known as Erigeron breviscapas vant Hand Mass, was first recorded in "Southern Yunnan Materia Medica". It is widely used clinically to treat hypertension, cerebral hemorrhage, coronary heart disease, angina pectoris and other diseases. The market economy has broad prospects, and its medicinal value is also being continuously developed. [0003] Now Erigeron breviscapus extract has not only become a cardiovascular and cerebrovascular drug with good curative effect, but also has been developed into a health care product. The main ingredients are total caffeic acid ester + scutellarin. [0004] Borneol (also known as borneol) is a commonly used traditional Chinese medicine. The 2010 edit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K47/38A61K47/32A61K47/02A61K36/28A61K31/045A61P9/00A61P9/10
CPCA61K9/2054A61K9/2027A61K9/2009A61K36/28A61K31/045A61P9/00A61P9/10A61K2300/00Y02A50/30
Inventor 林艳和
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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