High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof
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A chlortetracycline hydrochloride, water-soluble technology, applied in the field of highly water-soluble chlortetracycline hydrochloride soluble powder and its preparation, to achieve the effects of saving labor costs, changing solubility, and reducing the difficulty of drug administration
Active Publication Date: 2021-04-13
金河牧星(重庆)生物科技有限公司 +1
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[0023]Example one
[0024]Prescription screening:
[0025]It is an object of the present invention to obtain a stable high water-soluble hydrochloride soluble powder, and the prescription screening process mainly examines two indicators, solubility and stability.
[0026]1 solubility test
[0027]On the basis of a large number of tests, sodium triophosphate, sodium trimophosphate, sodium propylene acid, and sodium citrate are selected as a co-soluent, and is quantified to 100 g of a diluent to 100 g, and a level screening of a solvent is performed; single help The solvent test results are shown in Table 1:
[0028]Table 1 Single help solvent test results
[0029]
[0030]The results showed that sodium solvent diosphate and sodium triophosphate can significantly increase the solubility of the chordicin, and the solubility also increases as the amount of addition increases. The amount of dimerosphate added is 20%, and the solubility reaches the maximum. When the amount of sodium tripolyphosphate is 25%, t...
Example Embodiment
[0040]Example 2
[0041]A high water-soluble hydrochloride soluble powder, according to a percentage of mass, including the following raw materials: pkamycin 15% hydrochloride, 25% co-solvent, 60% sucrose 60%. The specific method of formulation includes the following steps:
[0042]S1. Weighing raw materials according to the ratio;
[0043]S2. Sieves separately;
[0044]S3. In the vacuum tab, the raw material is inhaled in the mixer, mixed for 25-35 minutes, which is the product.
Example Embodiment
[0045]Example 3
[0046]A high water-soluble hydrochloride soluble powder, according to a percentage of mass, including the following raw materials: pstamycin 11% hydrochloride, 30% of the aid solvent, 59% sucrose. The specific method of formulation includes the following steps:
[0047]S1. Weighing raw materials according to the ratio;
[0048]S2. Sieves separately;
[0049]S3. In the vacuum tab, the raw material is inhaled in the mixer, mixed for 25-35 minutes, which is the product.
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Abstract
The invention discloses high-water-solubility chlortetracycline hydrochloride soluble powder. The high-water-solubility chlortetracycline hydrochloride soluble powder comprises the following raw materials in percentage by mass: 10-30% of chlortetracycline hydrochloride, 15-30% of a cosolvent and 40-65% of a diluent. The invention further discloses a preparation method of the high-water-solubility chlortetracycline hydrochloride soluble powder. The preparation method comprises the following steps: S1, weighing the chlortetracycline hydrochloride, the cosolvent and the diluent in proportion; S2, respectively performing sieving; and S3, sucking the chlortetracycline hydrochloride, the cosolvent and the diluent into a mixer by using a vacuum feeding machine, and performing mixing for 25-35 minutes to obtain the high-water-solubility chlortetracycline hydrochloride soluble powder. According to the invention, a chelation solubilization process of the cosolvent and chlortetracycline hydrochloride is utilized to convert the chlortetracycline hydrochloride into chlortetracycline hydrochloride chelate with higher ionicity, so that the chlortetracycline hydrochloride chelate is easier to react with solvent water, and the solubility of the chlortetracycline hydrochloride in water is changed. According to the chlortetracycline hydrochloride soluble powder, the solubility of the chlortetracycline hydrochloride soluble powder can be improved to a level that 30 g or above of the chlortetracycline hydrochloride dissolves in every 1 L of water, a large-scale farm can conveniently perform dosing through dosers of various proportions, a dosing pipeline is not blocked, and the dosing convenience is remarkably improved.
Description
technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a highly water-soluble chlortetracycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Aureomycin hydrochloride is the active ingredient in the biosynthesis of Streptomycos aurcofacions, and it is a tetracyclic antibiotic. Chlortetracycline hydrochloride is the hydrochloride salt of chlortetracycline, which is golden yellow or yellow crystal, odorless, bitter in taste, gradually darkens when exposed to light, slightly soluble in water or ethanol, almost soluble in acetone, ether or chloroform insoluble. The extraction process of aureomycin hydrochloride is acidification and filtration of fermentation broth, precipitation, coarse crystallization and filtration, extraction, crystallization and washing, drying and mixing. [0003] As a basic veterinary chemical, aureomycin hydrochloride plays an important role in the devel...
Claims
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