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High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof

A chlortetracycline hydrochloride, water-soluble technology, applied in the field of highly water-soluble chlortetracycline hydrochloride soluble powder and its preparation, to achieve the effects of saving labor costs, changing solubility, and reducing the difficulty of drug administration

Active Publication Date: 2021-04-13
金河牧星(重庆)生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no product on the market that can meet the demand of 1:50 drug dosing device

Method used

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  • High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof
  • High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof
  • High-water-solubility chlortetracycline hydrochloride soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription Screening:

[0025] The purpose of the present invention is to obtain stable highly water-soluble chlortetracycline hydrochloride soluble powder, and the prescription screening process mainly investigates two indexes, solubility and stability.

[0026] ①Solubility test

[0027] On the basis of a large number of previous experiments, sodium dipolyphosphate, sodium tripolyphosphate, sodium malonate, and sodium citrate were selected as co-solvents, and glucose was used as a diluent to quantify to 100g, and the level of co-solvents was screened; a single co-solvent The solvent test results are shown in Table 1:

[0028] Table 1 Single cosolvent test results

[0029]

[0030] The results showed that both sodium dipolyphosphate and sodium tripolyphosphate as co-solvents could significantly improve the solubility of chlortetracycline, and the solubility also increased with the increase of the added amount. The addition of sodium dipolyphosphate is 20%, and t...

Embodiment 2

[0041] A highly water-soluble chlortetracycline hydrochloride soluble powder comprises the following raw materials in terms of mass percentage: 15% chlortetracycline hydrochloride, 25% cosolvent, and 60% sucrose. Its specific preparation method comprises the following steps:

[0042] S1. Weigh the raw materials according to the proportion;

[0043] S2. Sieving respectively;

[0044] S3. Use a vacuum feeder to suck the raw materials into the mixer, and mix for 25-35 minutes to obtain this product.

Embodiment 3

[0046] A highly water-soluble chlortetracycline hydrochloride soluble powder comprises the following raw materials in terms of mass percentage: 11% chlortetracycline hydrochloride, 30% cosolvent, and 59% sucrose. Its specific preparation method comprises the following steps:

[0047] S1. Weigh the raw materials according to the proportion;

[0048] S2. Sieving respectively;

[0049] S3. Use a vacuum feeder to suck the raw materials into the mixer, and mix for 25-35 minutes to obtain this product.

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Abstract

The invention discloses high-water-solubility chlortetracycline hydrochloride soluble powder. The high-water-solubility chlortetracycline hydrochloride soluble powder comprises the following raw materials in percentage by mass: 10-30% of chlortetracycline hydrochloride, 15-30% of a cosolvent and 40-65% of a diluent. The invention further discloses a preparation method of the high-water-solubility chlortetracycline hydrochloride soluble powder. The preparation method comprises the following steps: S1, weighing the chlortetracycline hydrochloride, the cosolvent and the diluent in proportion; S2, respectively performing sieving; and S3, sucking the chlortetracycline hydrochloride, the cosolvent and the diluent into a mixer by using a vacuum feeding machine, and performing mixing for 25-35 minutes to obtain the high-water-solubility chlortetracycline hydrochloride soluble powder. According to the invention, a chelation solubilization process of the cosolvent and chlortetracycline hydrochloride is utilized to convert the chlortetracycline hydrochloride into chlortetracycline hydrochloride chelate with higher ionicity, so that the chlortetracycline hydrochloride chelate is easier to react with solvent water, and the solubility of the chlortetracycline hydrochloride in water is changed. According to the chlortetracycline hydrochloride soluble powder, the solubility of the chlortetracycline hydrochloride soluble powder can be improved to a level that 30 g or above of the chlortetracycline hydrochloride dissolves in every 1 L of water, a large-scale farm can conveniently perform dosing through dosers of various proportions, a dosing pipeline is not blocked, and the dosing convenience is remarkably improved.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a highly water-soluble chlortetracycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Aureomycin hydrochloride is the active ingredient in the biosynthesis of Streptomycos aurcofacions, and it is a tetracyclic antibiotic. Chlortetracycline hydrochloride is the hydrochloride salt of chlortetracycline, which is golden yellow or yellow crystal, odorless, bitter in taste, gradually darkens when exposed to light, slightly soluble in water or ethanol, almost soluble in acetone, ether or chloroform insoluble. The extraction process of aureomycin hydrochloride is acidification and filtration of fermentation broth, precipitation, coarse crystallization and filtration, extraction, crystallization and washing, drying and mixing. [0003] As a basic veterinary chemical, aureomycin hydrochloride plays an important role in the devel...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/02A61K47/26A61K47/12A61K31/65A61P31/04
CPCA61K9/145A61K9/143A61K31/65A61P31/04
Inventor 李荣顺王建华方军秦斌周建
Owner 金河牧星(重庆)生物科技有限公司
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