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A kind of method and its application of recovery glucosamine hydrochloride mother liquor

A technology of glucosamine hydrochloride and glucosamine, applied in amino sugar, chemical instruments and methods, sugar derivatives, etc., can solve the problems of product waste and achieve high purity, low cost, and less chemical waste liquid

Active Publication Date: 2022-01-21
SHANDONG RUNDE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a considerable portion of glucosamine hydrochloride in the mother liquor, if not reclaimed, product waste will be caused

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for reclaiming glucosamine hydrochloride mother liquor, comprises the steps:

[0026] (1) Gradually lower the temperature of the mother liquor obtained from the preparation of glucosamine hydrochloride until glucosamine hydrochloride is precipitated, stop cooling and record the temperature at this time as the critical temperature, then heat the mother liquor to 3°C above the critical temperature, A metastable mother liquor was obtained.

[0027] (2) place the serpentine tube made of stainless steel with surface load marble slag in the metastable mother liquor of step (1), then pass into cooling water (temperature is 5 ℃) at one end of said serpentine tube, cooling water Flow out from the other end, and add ethanol with 0.3 times the volume of the mother liquor in the mother liquor as a precipitant, so that the glucosamine hydrochloride in the mother liquor gradually crystallizes on the surface of the marble slag on the surface of the serpentine tube.

[0028] ...

Embodiment 2

[0031] A method for reclaiming glucosamine hydrochloride mother liquor, comprises the steps:

[0032] (1) Gradually lower the temperature of the mother liquor obtained from the preparation of glucosamine hydrochloride until glucosamine hydrochloride is precipitated, stop cooling and record the temperature at this time as the critical temperature, then heat the mother liquor to 3°C above the critical temperature, A metastable mother liquor was obtained.

[0033] (2) place the serpentine tube made of stainless steel with surface load marble slag in the metastable mother liquor of step (1), then pass into cooling water (temperature is 8 ℃) at one end of said serpentine tube, cooling water Flow out from the other end, and add ethanol with 0.2 times the volume of the mother liquor in the mother liquor as a precipitant, so that the glucosamine hydrochloride in the mother liquor gradually crystallizes on the surface of the marble slag on the surface of the serpentine tube.

[0034] ...

Embodiment 3

[0037] A method for reclaiming glucosamine hydrochloride mother liquor, comprises the steps:

[0038] (1) Gradually lower the temperature of the mother liquor obtained from the preparation of glucosamine hydrochloride until glucosamine hydrochloride is precipitated, stop cooling and record the temperature at this time as the critical temperature, then heat the mother liquor to 2°C above the critical temperature, A metastable mother liquor was obtained.

[0039] (2) place the serpentine tube made of stainless steel with surface load marble slag in the metastable mother liquor of step (1), then pass into cooling water (temperature is 6 ℃) at one end of said serpentine tube, cooling water Flow out from the other end, and add acetone of 0.35 times the volume of the mother liquor in the mother liquor as a precipitant, so that the glucosamine hydrochloride in the mother liquor gradually crystallizes on the surface of the marble slag on the surface of the serpentine tube.

[0040] (...

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PUM

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Abstract

The invention relates to a method for recovering glucosamine hydrochloride mother liquor and its application. The method comprises the following steps: (1) cooling the mother liquor obtained by preparing glucosamine hydrochloride to above the critical temperature for the precipitation of glucosamine hydrochloride Within 3°C, a metastable mother liquor is obtained; (2) Place the tube body loaded with an induced crystallization carrier on the surface in the metastable mother liquor, then pass a flowing refrigerant into the pipe body, and add an organic precipitant to the mother liquor The temperature of the refrigerant is lower than the critical temperature, and the induced crystallization carrier is marble slag; (3) no glucosamine hydrochloride crystals are precipitated on the surface of the tube body, stop feeding the refrigerant, and then the tube body is taken out and heated with hot water Rinse off the crystals on the surface of the tube body to obtain a rinse solution; (4) Concentrate and crystallize the rinse solution to obtain the product. The method of the invention can not only effectively recover the glucosamine hydrochloride in the mother liquor, but also does not need complex refining procedures, so that the recovery of the mother liquor is more efficient.

Description

technical field [0001] The invention relates to the technical field of glucosamine preparation, in particular to a method for recovering glucosamine hydrochloride mother liquor and its application. Background technique [0002] Glucosamine hydrochloride (molecular formula: C 6 h 13 NO 5 HCl), also known as glucosamine hydrochloride, scientific name is 2-amino deoxyglucose hydrochloride, glucosamine hydrochloride is hydrolyzed by hydrochloric acid of chitin or chitosan, it is regarded as a fundamental As a drug for treating bone and joint diseases, glucosamine should be used in conjunction with chondroitin sulfate, which has the effects of relieving pain and promoting cartilage regeneration, and can fundamentally improve joint problems. In addition, glucosamine hydrochloride can also prevent the accumulation of cholesterol in the human body, and has the effect of health care and anti-aging. [0003] At present, the preparation of glucosamine hydrochloride generally adopts...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/06C07H5/06
CPCC07H1/06C07H5/06
Inventor 许可卢健行张新平柏帅张倩水清洋卢建智
Owner SHANDONG RUNDE BIOTECH CO LTD