Alginate antibacterial composite film and preparation method thereof

Abstract

The invention provides an alginate antibacterial composite membrane which is obtained by cross-linking nano-cellulose membranes with double-layer structures, and the nano-cellulose membrane with the double-layer structure is obtained by coaxial electrostatic spinning of an electrostatic spinning shell solution and an electrostatic spinning core solution, wherein the electrostatic spinning shell solution comprises chitosan, sodium alginate, lysozyme and a solvent A, and the solvent A is a mixed solution of weak acid, alcohol and water; and the electrostatic spinning core solution comprises bioactive glass, agarose acetate and an organic solvent. Fibers of the alginate antibacterial composite membrane have the characteristics of hydrophilic exterior and hydrophobic interior, the overall performance is more uniform, the alginate in a shell layer absorbs liquid and thus is hydrophilic, the lysozyme promotes epithelialization, a core layer transmits liquid hydrophobically, controlled release and bacteriostasis are achieved, support is provided for the shell layer, the overall shape retention of the product is good, and the application range is wider. The alginate antibacterial composite membrane disclosed by the invention has excellent liquid diffusion performance and antibacterial performance.

Description

technical field [0001] The invention relates to the field of antibacterial composite materials, in particular to an alginate antibacterial composite film and a preparation method thereof. Background technique [0002] The existing liquid-absorbable film / sheet products usually only focus on the hydrophilicity of the product. Even if the material itself has good absorption performance, because the liquid often only accumulates in one place, it cannot achieve rapid and uniform absorption. It is easy to cause local swelling or deformation during use, and it is also easy to cause leakage, especially when the liquid is at the edge, the absorption efficiency is even lower. On the other hand, conditions with high humidity tend to breed bacteria easily. Traditional products have added antibacterial function through physical loading, which has the characteristics of difficult release control, unstable concentration of antibacterial substances, and low safety. As an emerging material ...

AI Technical Summary

Problems solved by technology

[0002] The existing liquid-absorbable film / sheet products usually only focus on the hydrophilicity of the product. Even if the material itself has good absorption performance, because the liquid often only accumulates in one place, it cannot achieve rapid and uniform absorption. It is easy to cause local swelling or deformation during use, and it is also easy to cause leakage, especially when the liquid is on the edge, the absorption efficiency is even lower

On the other hand, conditions with high humidity tend to breed bacteria easily. The antibacterial function added by traditional products through physical loading has the characteristics of difficult release control, unstable concentration of antibacterial substances, and low safety.

As an emerging material in the biological world, bioactive glass is favored due to its excellent bacteriostasis and biological activity, but it is highly alkaline, and if it is released in large quantities when in contact with liquids, it will easily cause the pH value of the local environment to rise and cause discomfort , thus limiting its application

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