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Degradable medical film and preparation method thereof

A film and medical technology, applied in the field of degradable medical film and its preparation, can solve the problems of poor stretchability, poor adhesion of tissue patches, uncontrollable degradation time, etc., and achieve strong adhesion, easy drying process, and solvent The effect of low residue

Pending Publication Date: 2021-04-30
SHANGHAI SUOKANG MEDICAL IMPLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of poor adhesion, poor stretchability and uncontrollable degradation time of the tissue patch, and to provide a method for preparing a biodegradable medical film with tissue adhesion. This kind of functional film has good adhesion, Stretch resistance and uncontrollable degradation time, applied to the inner surface of local tissues of the body to achieve the purpose of hemostasis, sealing and helping wound healing

Method used

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  • Degradable medical film and preparation method thereof
  • Degradable medical film and preparation method thereof
  • Degradable medical film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072]First, the synthesis of the biological tissue adhesive material can be degraded

[0073]Step 1: Add Acrylic (AAC) 5 mol, N-vinyl-2-pyrrolidone (NVP) 5 mol, azo diisobutyronitrile (AIBN) 6g, and dimethyl sulfoxide 10L, and the reaction kettle is added to 70 ° C, Continuous reaction for 12 hours; the reaction is as follows:

[0074]

[0075]Step 2: Start cooling, set the temperature of 25 ° C, add N-hydroxy succinimide 2.5 mol, bicyclic hexyl carbon diimide (DCC) 3 mol within the reactor, continued to react 48 hours; the reaction formula is as follows:

[0076]

[0077]Step 3: After the reaction is completed, the material is filtered, and the filter cake is filtered, and the filtrate is retained, the synthesized trimer remains in the filtrate to obtain the first crude product.

[0078]Step 4: The first crude product was slowly added dropwise to 100 L of ethyl acetate to obtain a second crude product; the purpose of this step was coarse washed (purified) to obtain a trimer solid.

[0079]The method o...

Embodiment 2

[0091]Example 2 (a small amount of multiple coating film)

[0092]According to the clinical needs and convenient production operation, a small amount of multiple coating film can be taken, using an ABAB structure, a small amount of multi-level coating method, the drying process is relatively easier, so that the solvent residue is lower, and the safety requirements of medical devices can be in line with the safety requirements of medical equipment. .

[0093]I. Synthesis of degradable biological tissue adhesive materials

[0094]Synthesis of the degradable biological tissue adhesive material in Example 1.

[0095]Second. Making film (coating film)

[0096]Step 1, dissolve the substrate layer material polylactic acid (PLGA, monomer ratio 85:15, viscosity 0.8) in dichloromethane, configure a mass fraction of 5% -10% of the PLGA solution; the degradable organism prepared The tissue adhesive material is dissolved in a mixed solvent having a volume ratio of 3: 1 dichloromethane with methanol, and the ma...

Embodiment 3

[0102]The method is coated in the first direction, and the first adhesion layer (second film) is coated in the second direction, the second direction and the first The angle in one direction is 90 °; the second support layer (third film) is disposed along the third direction, the third direction and the angle of the first direction are -90 °; the second adhesion layer (No. The 4-layer film is provided in the fourth direction, the fourth direction is 0 ° in the first direction.

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Abstract

The invention discloses a degradable medical film and a preparation method thereof. The film is of a multi-layer structure, the multi-layer structure comprises at least one AB-type composite structure arranged in an alternate coating mode, the AB-type composite structure is a structure formed by compounding a supporting layer and an adhesion layer, and the outermost layer of the film is provided with the supporting layer and the adhesion layer, wherein the coating directions of the supporting layer and the adhesion layer which are adjacently coated are different. According to the medical film provided by the invention, the two composite components A and B are coated in a crossed manner, so that the supporting effect of the component A and the tissue adhesion effect of the component B are enhanced, the degradation time is controllable, and the degradation period is adjusted according to different use parts and clinical requirements. Base materials with different molecular weights can be selected according to different use parts and different requirements on the strength of the sealing film; and the medical film is convenient to use, does not need to be fixed by traditional sewing, and achieves an instant effect. The medical film can be gradually degraded, absorbed and metabolized, and the sealing film does not need to be removed.

Description

Technical field[0001]The present invention belongs to the technical field of medical materials, and more particularly to a degradable medical film and a preparation method thereof.Background technique[0002]His old disease is natural law, for some diseases, the use of surgical methods is still the main treatment. When the human body tissue or organ is cut, the wound needs to be treated quickly, and some need to be sewed to help tissue hea. However, the sewing method cannot reach an absolute seal, which cannot solve low pressure leakage or slow bleeding.[0003]At first, people tried to use fibers to form a viscous liquid or gel, apply it to the tissue wound, and act to hemostasis, promote healing. This method has a certain effect, but there is obvious defects; if liquid is too viscous, it is easy to reunion and cannot effectively disperse the clotquey; if the rally flows well, it cannot accurately block the wound area, resulting in inconvenient use. Before using, you need to make mix, ...

Claims

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Application Information

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IPC IPC(8): A61F13/515A61F13/53A61L15/24A61L15/26A61L15/42A61L15/62C08J5/18C08F220/06C08F226/10C08F8/30C08L67/04C08L39/06
CPCA61F13/515A61F13/53A61F2013/530313A61F2013/530795A61L15/24A61L15/26A61L15/42A61L15/62A61L2400/04C08F8/30C08F220/06C08F226/10C08J5/18C08J2339/06C08J2367/04
Inventor 叶明李新华
Owner SHANGHAI SUOKANG MEDICAL IMPLANTS
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