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Preparation method of chondroitin sulfate sodium

A technology of sodium chondroitin sulfate and chondroitin sulfate, which is applied in the field of sodium chondroitin sulfate, can solve the problems of large amount of sodium hydroxide solution, long extraction time, and low product purity, so as to shorten the extraction time, reduce the processing process, and produce The effect of high rate and purity

Inactive Publication Date: 2021-04-30
四川菲德力制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For above-mentioned deficiency in the prior art, the invention provides a kind of preparation method of chondroitin sulfate, this method can effectively solve the sodium hydroxide solution amount that existing method exists is many, causes waste and environmental pollution, extraction time is long and The problem of low product purity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]Method for preparing sodium sulfate sodium sodium sulfate, including the following steps:

[0041](1) The cow's nose, trachea or throat, etc., the bovine raw material, etc., the heat of the bone is increased to 60 ° C for cooking for 2 h, while stirring, and pulverizing the cartilage is removed from 4 mm, and the cartilage powder is obtained;

[0042](2) Add sodium hydroxide and silica mixed powder to the end of the cartilage powder, co-research 3 min, wherein the mass ratio of the cartilage powder and the sodium hydroxide and the silica mixture is 5: 1, the mixture, sodium hydroxide The mass ratio of sulfur dioxide is 3: 1; then the mixture is added to the sodium chloride solution having a mass concentration of 2%, the volume ratio of the cartilage powder and sodium chloride solution is 1: 4, the adjustment pH is 5.5, centrifuged, collectively Liquid;

[0043](3) Adding water in the precipitate in the step (2), the volume ratio of the precipitation and water is 1: 4, and the solution ...

Embodiment 2

[0049]Method for preparing sodium sulfate sodium sodium sulfate, including the following steps:

[0050](1) The cow's nose, trachea or laryngeal bone is added to 80 ° C for cooking from 80 ° C, stirring, and pulverizing the cartilage to 4 mm after taking the cartilage;

[0051](2) Add sodium hydroxide and silica mixed powder to the end of the cartilage powder, co-research 3 min, of which the mass ratio of the cartilage powder to the sodium hydroxide and the silica mixture is 8: 1, the mixture, sodium hydroxide The mass ratio of sulfur dioxide is 5: 1; then the mixture is added to the sodium chloride solution having a mass concentration of 4%, the volume ratio of the cartilage powder and the sodium chloride solution is 1: 6, the adjustment pH is 6.5, centrifuged, collected Liquid;

[0052](3) Adding water to the precipitate in the step (2), the volume ratio of precipitation and water is 1: 6, and the pH of the solution is adjusted with sodium hydroxide to 9, warm to 60 ° C, heat insulation 2h...

Embodiment 3

[0058]Method for preparing sodium sulfate sodium sodium sulfate, including the following steps:

[0059](1) The sternum material such as the catastrophe, trachea or throat and other cullets is increased to 70 ° C for cooking for 2 h, while stirring, and pulverizing the cartilage to 3 mm, resulting in cartilage powder;

[0060](2) Add a sodium hydroxide and silica mixed powder to the end of the cartilage powder, co-study of 2 min, of which the mass ratio of the cartilage powder and sodium hydroxide and the silica mixture is 6: 1, the mixture, sodium hydroxide The mass ratio of sulfur dioxide is 3: 1; then the mixture is added to a sodium chloride solution having a mass concentration of 3%, the volume ratio of the cartilage powder and sodium chloride solution is 1: 5, the adjustment pH is 6, centrifuged, collectively Liquid;

[0061](3) Adding water in the precipitate in the step (2), the volume ratio of precipitation and water is 1: 5, and the pH of the solution is adjusted with sodium hydrox...

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Abstract

The invention discloses a preparation method of chondroitin sulfate sodium. The method comprises the following steps: adding water into a cartilage raw material, cooking, taking out, and pulverizing to obtain cartilage powder; adding mixed powder of sodium hydroxide and silicon dioxide into the cartilage powder, co-grinding, adding a sodium chloride solution, adjusting the pH value, centrifuging and collecting supernatant; carrying out alkali extraction on the precipitate, centrifuging, and collecting the supernatant; mixing the supernatant, adjusting the pH value to 8-10, and then adding alkaline protease for enzymolysis to obtain a chondroitin sulfate solution; adding an adsorbent, keeping standing, carrying out filter pressing, and collecting a filtrate; and adding ethanol with different concentrations into the filtrate by stages for purification to obtain the product. The method can be used to effectively solve the problems of waste, environmental pollution, long extraction time and low product purity caused by a large amount of sodium hydroxide solution in the existing method.

Description

Technical field[0001]The present invention relates to the field of chondroose sulfate sulfate, and more particularly to a method of preparing sodium sulfate sodium sulfate.Background technique[0002]Chondroitin Sulfate, CS) is a kind of adhesive polysaccharide, strong water absorption, more white powder, easy to moisture, soluble in water, is not soluble in organic solvents such as ethanol, chloroform, acetone, widely distributed In the body tissue, such as pigs, cows, sheep, fish, etc., especially animal cartilage tissue, such as laryngeal bones, nasal bone, trachea, etc., mainly from N-acetyl galactosamine (2-acetamide-2 Sodium sulfate salt of deoxy-β-D-gyramolitrose) and D-glucuronic acid copolymer, copolymer has a copolymer endochagal through β-1, 3 and β-1,4 glycoside bonds, can be wide Applicable to neuropathic headache, neuralgia, joint pain, migraine, arteriosclerosis, and other symptoms, can also be used for auxiliary treatment of symptoms such as streptomycin and hepatitis....

Claims

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Application Information

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IPC IPC(8): C08B37/08
CPCC08B37/0003C08B37/0069
Inventor 叶长蓉
Owner 四川菲德力制药有限公司
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