Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof

A technology of polymer material and temperature-sensitive polymer, which is applied in the field of temperature-sensitive polylactic acid polymer material and its preparation, can solve the problems of high cost, difficult application, complicated preparation process of temperature-sensitive polymer, etc.

Active Publication Date: 2021-05-07
SOUTH CHINA NORMAL UNIVERSITY
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It is worth noting that the modification of polylactic acid based on temperature-sensitive polymers is either too expensive or the preparation process of temperature-sensitive polymers is complicated, and most of them cannot meet the requirements of low cost, simple process and adjustable material properties at the same time. and other conditions, it is difficult to have further application [Cho H, Gao J, Kwon G S.J Control Release,2016,240:191]

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof
  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof
  • Thermo-sensitive polylactic acid high-molecular material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] The invention provides a temperature-sensitive polylactic acid polymer material, the preparation method of which is as follows:

[0046] Firstly, the prepolymer is prepared by a one-time feeding method, a magnetic stirrer is placed in a fully dry reaction flask, lactic acid monomer and maleic anhydride are added to the reaction flask, and the electromagnetic stirring is turned on. Dehydration at normal pressure first, and then vacuum prepolymerization to obtain prepolymer.

[0047] Then, a catalyst is added to the prepolymer to catalyze direct melt polymerization. Next, remove the vacuum, add temperature-sensitive polymer monomers and initiators into the above reaction system, and start electromagnetic stirring to carry out the reaction.

[0048] Finally, purify the product, first dissolve the product with a solvent, heat the product if necessary, and then use deionized water to precipitate and wash it. After filtering, the filter residue is heated and dried in a vacuu...

Embodiment 1

[0054] Copolymer PLAMN 4 Synthesis:

Embodiment 2

[0057] Copolymer PLAMN 7 Synthesis:

[0058] Put a magnetic stirring bar into the reaction flask, add about 3.6g (40mmol) of lactic acid monomer and 0.2g (2mmol) of maleic anhydride into the reaction flask, and start stirring. Under normal pressure, dehydrate at 130°C for 6 hours, then vacuumize with a circulating water vacuum pump, and prepolymerize for 8 hours. After the prepolymerization, add 0.01g catalyst SnO, vacuumize with a rotary vane vacuum oil pump, and polymerize at 140°C for 3h. Release the vacuum, add 1.6g (14mmol) of N-isopropylacrylamide and 0.02g of potassium persulfate, and polymerize at 100°C for 4h. After the polymerization, the product was dissolved with methanol, and then precipitated and washed with deionized water. After filtration, the filter residue was dried in a vacuum oven at 45°C for 24 hours to obtain the copolymer PLAMN 7 , the yield was 49%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Phase transition temperatureaaaaaaaaaa
Phase transition temperatureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a thermo-sensitive polylactic acid high-molecular material and a preparation method and application thereof, the structural formula of the thermo-sensitive polylactic acid high-molecular material is shown in the specification, R is a polymerization chain segment of a thermo-sensitive polymer monomer, n is an integer between 10 and 100, q is an integer between 10 and 10, and m is an integer between 10 and 100. The novel polylactic acid high-molecular material is obtained by carrying out copolymerization reaction on cheap and easily available bio-based lactic acid monomers, simple maleic anhydride and temperature-sensitive polymer monomers through direct melt polycondensation by a one-pot method, and the polylactic acid high-molecular material has temperature sensitivity and biodegradability. The material is expected to be used as a carrier of small molecular drugs or antibacterial drugs, or can be directly used as a wound dressing base material in a form of powder, which is blended with a solvent into a gel form or spun into a fibrous form.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a temperature-sensitive polylactic acid polymer material and its preparation method and application. Background technique [0002] Polylactic acid polymer materials are widely used in biomedical research because of their good biocompatibility, biodegradability, and adjustability. Deliver or trigger drug release. [0003] The methods for preparing temperature-sensitive polylactic acid macromolecular materials reported in the literature include the following: [0004] (1) Using polyamide polymers such as poly-N-isopropylacrylamide (PNIPAM) and poly-N-vinylcaprolactam (PNVCL) as raw materials to modify polylactic acid materials to prepare functionalized temperature-sensitive polylactic acid materials [Alexander A, Khan J, Saraf S, et al. Eur J Pharm Biopharm, 2014, 88(3): 575; Zhao H L, Tao L, Yu R, et al. JNanosci Nanotechnol, 2015, 15(8): 5553 ; Seidi F, Heshmati P. C...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08F283/01C08F220/54
CPCC08F283/01C08F220/54
Inventor 罗时荷汪朝阳肖颖
Owner SOUTH CHINA NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com