Resveratrol lamellar liquid crystal and preparation method thereof

A technology of resveratrol and lamellar liquid crystals, which can be used in pharmaceutical formulations, medical preparations of non-active ingredients, drug delivery, etc. It can solve the problems of inability to stay in the cornea for a long time, reduce patient compliance, and increase adverse reactions. , to achieve the effects of inhibiting corneal neovascularization, promoting corneal epithelial repair, and enhancing drug permeability

Pending Publication Date: 2021-05-14
中国人民解放军总医院第三医学中心
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Eye ointment tends to have a high viscosity. Although it prolongs the residence time in the conjunctival sac, it is inconvenient to administer and has a greasy feeling when used, and it will blur the vision. It is not suitable to use it during the day
In addition, the use of organic solvents in ophthalmic preparations is less, and for water-insoluble drugs, the drug loading that can be provided is often limited
Therefore, the two cannot achieve high drug loading or long-term retention in the cornea, so that patients need to be repeatedly administered in clinical use, reducing patient compliance and increasing local adverse reactions

Method used

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  • Resveratrol lamellar liquid crystal and preparation method thereof
  • Resveratrol lamellar liquid crystal and preparation method thereof
  • Resveratrol lamellar liquid crystal and preparation method thereof

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Embodiment Construction

[0036] The present invention will be described in detail below by way of examples. The examples of said embodiments are intended to explain the invention and are not to be construed as limiting the invention. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0037] Preparation and Characterization of Resveratrol Lamellar Liquid Crystals (ROLG)

[0038] 1. Experimental materials

[0039] (1) Experimental reagents:

[0040]

[0041] (2) Experimental equipment:

[0042]

[0043] 2. Experimental method

[0044] (1) Preparation of Resveratrol Lamellar Liquid Crystals

[0045] Resveratrol (42.0 mg) was dissolved in ethanol (0.6 g) to obtain a resveratrol-ethanol solution...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a resveratrol lamellar liquid crystal and a preparation method thereof. The resveratrol lamellar liquid crystal contains resveratrol, glyceryl monooleate, alcohol and water, the mass ratio of the glyceryl monooleate to the resveratrol is larger than or equal to 16: 1, and the mass ratio of the glyceryl monooleate to the alcohol to the water is (2-10): (0.2-1): (1-10); the alcohol is selected from at least one of ethanol, propylene glycol and polyethylene glycol. The resveratrol lamellar liquid crystal provided by the invention is high in drug loading capacity and good in safety, can enhance the drug permeability of corneal tissues, can release drugs for a long time, can obviously reduce corneal VEGF expression, inhibit rat corneal neovascularization growth and promote corneal epithelium repair, and is expected to become a novel local drug preparation for treating corneal alkali burn. And a new thought is provided for treatment of corneal alkali burn.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a resveratrol layered liquid crystal and a preparation method thereof. Background technique [0002] Corneal neovascularization (CNV) is a pathological angiogenesis after corneal injury, which is often caused by ocular inflammation, contact lens, chemical injury, immune disease and corneal surgery (such as corneal transplantation). CNV can affect corneal refraction, leading to vision loss or even blindness in patients. The mechanism of CNV formation is due to an imbalance between pro- and inhibitory angiogenic factors within the cornea. The main angiogenic factors include: vascular endothelial growth factor (VEGF), fibroblast growth factor, platelet-derived growth factor, etc. Anti-angiogenic factors mainly include: pigment epithelium-derived factor, endostatin and angiostatin Su and so on. Among them, VEGF is the strongest angiogenesis-promoting factor f...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/54A61K47/69A61K31/05A61P27/02
CPCA61K9/0048A61K47/543A61K47/6953A61K31/05A61P27/02
Inventor 吴志鸿李敏姝
Owner 中国人民解放军总医院第三医学中心
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