Resveratrol lamellar liquid crystal and preparation method thereof

A technology of resveratrol and lamellar liquid crystals, which can be used in pharmaceutical formulations, medical preparations of non-active ingredients, drug delivery, etc. It can solve the problems of inability to stay in the cornea for a long time, reduce patient compliance, and increase adverse reactions. , to achieve the effects of inhibiting corneal neovascularization, promoting corneal epithelial repair, and enhancing drug permeability
CN112791047APending Publication Date: 2021-05-14中国人民解放军总医院第三医学中心
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
中国人民解放军总医院第三医学中心
Publication Date
2021-05-14

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Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a resveratrol lamellar liquid crystal and a preparation method thereof. The resveratrol lamellar liquid crystal contains resveratrol, glyceryl monooleate, alcohol and water, the mass ratio of the glyceryl monooleate to the resveratrol is larger than or equal to 16: 1, and the mass ratio of the glyceryl monooleate to the alcohol to the water is (2-10): (0.2-1): (1-10); the alcohol is selected from at least one of ethanol, propylene glycol and polyethylene glycol. The resveratrol lamellar liquid crystal provided by the invention is high in drug loading capacity and good in safety, can enhance the drug permeability of corneal tissues, can release drugs for a long time, can obviously reduce corneal VEGF expression, inhibit rat corneal neovascularization growth and promote corneal epithelium repair, and is expected to become a novel local drug preparation for treating corneal alkali burn. And a new thought is provided for treatment of corneal alkali burn.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a resveratrol layered liquid crystal and a preparation method thereof. Background technique

[0002] Corneal neovascularization (CNV) is a pathological angiogenesis after corneal injury, which is often caused by ocular inflammation, contact lens, chemical injury, immune disease and corneal surgery (such as corneal transplantation). CNV can affect corneal refraction, leading to vision loss or even blindness in patients. The mechanism of CNV formation is due to an imbalance between pro- and inhibitory angiogenic factors within the cornea. The main angiogenic factors include: vascular endothelial growth factor (VEGF), fibroblast growth factor, platelet-derived growth factor, etc. Anti-angiogenic factors mainly include: pigment epithelium-derived factor, endostatin and angiostatin Su and so on. Among them, VEGF is the strongest angiogenesis-promoting factor f...

Claims

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