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Blueberry xanthophyll eye drops capable of relieving eyestrain and preparation method thereof

A technology of berry lutein and eye drops, applied in the field of biomedicine, can solve problems such as eye irritation, achieve the effects of good solubility, reduced drug waste and easy portability

Pending Publication Date: 2021-05-14
JINAN RUILONGAN BIOTECHNOLOGY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the commonly used drugs for the above-mentioned visual fatigue and other symptoms include antihistamines (such as 0.1% emedastine, 0.05% levocabastine), mast cell stabilizers (such as disodium cromoglycate and nedocromil, etc.) ), non-steroidal anti-inflammatory drugs, vasoconstrictors, glucocorticoids, and immunosuppressants, etc. However, the inventors have found that the active ingredients of the above-mentioned medicines are mainly western medicine ingredients, which are often harmful to the eyes when they are made into eye drops. Certain stimulating effect, long-term use will produce certain dependence, and eye drops are usually added with antibacterial agents and preservatives, long-term use is easy to cause eye irritation

Method used

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  • Blueberry xanthophyll eye drops capable of relieving eyestrain and preparation method thereof
  • Blueberry xanthophyll eye drops capable of relieving eyestrain and preparation method thereof
  • Blueberry xanthophyll eye drops capable of relieving eyestrain and preparation method thereof

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preparation example Construction

[0051] In yet another specific embodiment of the present invention, the preparation method of the above-mentioned eye drops is provided, and the preparation method comprises:

[0052] The blueberry extract and lutein are dissolved in the solution, and an osmotic pressure regulator and a pH regulator are added.

[0053] Wherein said solution is an aqueous solution containing a stabilizer.

[0054] In yet another specific embodiment of the present invention, the solution is water for injection containing hydroxypropyl β-cyclodextrin and hydroxypropyl methylcellulose.

[0055]In yet another specific embodiment of the present invention, the osmotic pressure molar concentration of the solution is adjusted to 280mOsmol / L-320mOsmol / L using an osmotic pressure regulator; (equivalent to tear osmolarity)

[0056] In yet another specific embodiment of the present invention, a pH regulator is used to adjust the pH of the solution to 6.5-7.5.

[0057] In yet another specific embodiment o...

Embodiment 1

[0080] The preparation of embodiment 1 blueberry extract and the preparation of blueberry extract eye drops

[0081] (1) Weigh 500g of dried and crushed blueberry powder, add 12.5L of 70% ethanol, ultrasonicate at 250W ultrasonic frequency for 40min, extract at 60°C, rotary evaporate, add water at a ratio of 1:5 after drying, and adjust to pH is 5.5;

[0082] (2) According to 8000U / g blueberry powder, add compound glycosidase, enzymatic hydrolysis for 8 hours, enzymatic hydrolysis temperature 40 ℃, 90 ℃ inactivate enzyme for 15 minutes; compound glycosidase is the combination of β-D-glucosidase and α-L-arabinosidase Mixture; the dosage ratio of β-D-glucosidase and α-L-arabinosidase is 1:2 (calculated by enzyme activity);

[0083] (3) Filtration, rotary evaporation, drying and pulverization to obtain blueberry extract A (4.977g), the specific components are shown in Table 1;

[0084] (4) Blueberry extract eye drops are prepared according to the following prescription and ste...

Embodiment 2

[0100] The preparation of embodiment 2 blueberry extract and the preparation of blueberry extract eye drops

[0101] (1) Weigh 500g of dried and pulverized blueberry powder, add 15L of 70% ethanol, ultrasonicate at 200W ultrasonic frequency for 50min, extract at 60°C, rotate to evaporate, add water at a ratio of 1:5 after drying, and adjust the pH to 5.5;

[0102] (2) Add compound glycosidase 9000U / g, enzymolysis 6h, enzymolysis temperature 40 ℃, 90 ℃ inactivate enzyme 15min; described compound glycosidase is β-D-glucosidase and α-L-arabinosidase, two The enzyme activity ratio is 1:2.

[0103] (3) Filtration, rotary evaporation, drying and pulverization to obtain blueberry extract A;

[0104] (4) Blueberry extract eye drops are prepared according to the following prescription and steps

[0105] prescription

[0106] Blueberry Extract A 1g

[0107] Lutein 2g

[0108] Hydroxypropyl beta-cyclodextrin 4g

[0109] Hydroxypropyl Methyl Cellulose 2g

[0110] Appropriate amo...

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Abstract

The invention provides blueberry xanthophyll eye drops for relieving eyestrain and a preparation method thereof, and belongs to the technical field of biological medicines. Research finds that a blueberry extract and xanthophyll prepared by the invention both have the health-care efficacy of relieving eyestrain, can better relieve eye dryness, soreness and swelling, prevent myopia and enhance vision, and have an obvious improvement effect on senile retina macular region lesions. The two components have a synergistic effect, meanwhile, by reasonably adding related auxiliary materials, the composition eye drops containing the blueberry extract are finally prepared, and tests prove that the curative effect is remarkable, so that the composition eye drops have a good practical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a blueberry lutein eye drop for relieving eye fatigue and a preparation method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] With the popularization of electronic equipment and the acceleration of the pace of modern life and work, the number of people with visual fatigue continues to increase. The specific manifestations are dry eyes, soreness, intermittent blurred vision, and decreased vision. In severe cases, nausea, dizziness, and headaches may even occur. and other symptoms directly affect people's work and life. [0004] At present, the commonl...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61K9/08A61K47/40A61P27/02A61P9/10A61P27/10A61K31/047
CPCA61K9/0048A61K9/08A61K31/047A61K36/45A61K47/40A61P9/10A61P27/02A61P27/10A61K2300/00
Inventor 刘飞王锐牛林林马文靖陈勉李倩袁丹丹田晓庆陈磊韩莉张晓元张艳艳
Owner JINAN RUILONGAN BIOTECHNOLOGY CO LTD
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