Medicine and food for resisting new corona-virus infection and application

A virus infection and virus infection-related technology, applied in the direction of antiviral agents, applications, food science, etc., can solve the problems of inability to control the digestive system infection of the new coronavirus, low risk of clinical benefits, and affect work and life, etc., to achieve improvement Effects of intestinal barrier function, shortening the course of disease, and relieving symptoms of digestive system

Active Publication Date: 2021-05-14
GUANGZHOU CENTURY CLINICAL RES CO LTD +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although some antiviral drugs have been emergency approved or recommended, such as interferon, oseltamivir, lopinavir, ritonavir, favipiravir, ribavirin, remdesivir, chloroquine, However, most of the existing drugs have adverse reactions of varying degrees, especially for asymptomatic infection or mild patients, and the clinical benefit-risk ratio is very low
In addition, it happens from time to time that the nucleic acid test of the new coronavirus in patients turns negative and then returns to positive; some patients have reported that after the viral nucleic acid of respiratory specimens turns negative, the stool samples are still positive for a long time; it shows that the current antiviral drugs cannot Good control of the digestive system infection of the new coronavirus
The persistent infection of the new coronavirus is an important factor hindering the recovery of patients. For asymptomatic patients or patients with mild clinical symptoms in the recovery period of new coronary pneumonia, if the virus still cannot turn negative, continuous centralized isolation and medical observation are required. Seriously affect normal work and life

Method used

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  • Medicine and food for resisting new corona-virus infection and application
  • Medicine and food for resisting new corona-virus infection and application
  • Medicine and food for resisting new corona-virus infection and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082]Example 1: Application of lysozyme in patients with new coronal pneumonia and high risk infected population

[0083]During the Chinese New Crown Pneumonia epidemic, our company donated two more than 2 million yuan to Hubei Province, including lysozyme-containing tablets, lysozyme-coated tablets and other antibacterial drugs. These drugs play a positive role in fighting new champions. After many patients voluntarily tuned our company's lyse enzyme products.

[0084]9 new crown pneumonia newly diagnosed patients taking the lysozyme-containing sheet and / or lycipatinolic sheet, the dose of taking is 0.5g-2g daily, and the daily basically insists, and the results are only converted to In the case of a critical illness, the other 8 is mild, and then healed. The calculated concentration is 11.1%.

[0085]There are 3 people, during the epidemic, live and business trips in high-risk areas, insist on taking lysozyme-containing tablets and / or lycosolite tablets daily, and the amount is 1 g-1....

Embodiment 2

[0087]Example 2: In vitro test of lyse enzyme anti-new crown virus

[0088]The effect of lysease anti-COVID-19 new crown virus was studied with African green monkey renal cells.

[0089]Drugs: lysozyme, mono glycyrrhid acid.

[0090]Cells: African green monkey renal cells (VeroE6 cells).

[0091]Virus: COVID-19, saved by Guangzhou Customs Technology Center, using a titer of 100Tcid50.

[0092]Culture: Sterile 96-well culture plate, 100 μl of concentration of 100 μl of concentration of 2 × 10 per hole5Cells / ml VeroE6 cells were cultured at 37 ° C for 24 hours. The culture plate is divided into a blank control group, a viral control group, a low dose group, a lyse enzyme high dose group, a linsene acid mono metaphanylammonium, and a high-dose group of glycyrrhizic acid. 3 holes. In addition to the blank control group, 100Tcid is added in each group.50Virus 5μl / well, 5% CO at 37 ° C2After 2 hours of incubator, the cell culture medium in the culture plate was discarded.

[0093]Pharmaceutical: The dr...

Embodiment 3

[0098]Example 3: In vitro trial of the combined anti-neogous crown virus and new crown virus caused by

[0099]The inhibition of cytoplasms caused by lysozymes on cytoplasm caused by new crown viruses, as well as inhibitory effects of inflammation caused by new crown viruses.

[0100]Both drugs, cells, viruses, etc. are the same as in Example 2.

[0101]The culture plate group and the dose of the dosing were: blank control group, viral control group, lyse group (350 μg / ml), lycoshanol mono ammonium I group (100 μg / ml + 1 μg / mL), lyse enzyme glycyrrhizone Group II group (100 μg / ml + 5 μg / ml), a monogenic group (100 μg / ml + 10 μg / ml), lycozyme glycolic acid single ammonium IV group (100 μg / ml + 50 μg / mL).

[0102]The observed cell lesions were the same as in Example 2, and the test results are shown in Table 2. In addition, non-pathogenic cells were collected, and RNA was extracted, and the relative expression levels of inflammatory factors such as TNF-α, IL-6 were determined by...

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Abstract

The invention discloses a medicine and food for resisting new corona-virus infection and application. The medicine or food contains lysozyme or a combination containing the lysozyme. The lysozyme or the combination thereof can be used for preparing medicines for resisting new corona-virus infection and preventing or treating diseases or symptoms related to new corona-virus or food for assisting in resisting new corona-virus infection and assisting in preventing or treating diseases or symptoms related to new corona-virus. The lysozyme or the combination thereof can effectively inhibit cell injury and inflammatory response caused by the new corona-virus, relieve symptoms of a digestive system, improve airway obstruction, expiration volume reduction and intestinal barrier functions, and have good prevention and treatment effects on new corona-virus infection or related diseases or symptoms thereof; in addition, in-vivo removal of the virus is accelerated, in-vivo new corona-virus nucleic acid detection negative conversion speed is accelerated, the disease course of a patient is shortened, transmission of the new corona-virus is effectively prevented and reduced, and important social benefits and good application prospects are achieved.

Description

Technical field[0001]The present invention relates to the field of medicine, and more particularly to drugs, food and applications of anti-championship infection and control of new crown virus-related diseases or symptoms.Background technique[0002]The World Health Organization announced that new crown pneumonia epidemics caused by new crown virus infections in March 2020, which is still a huge burden and threat in the world of public health in the world. Until now, the number of people infected with the global infection has not arrived, and some areas have successfully controlled the spread of the epidemic through various measures, and the third round of the epidemic emergence, the global new crown epidemic is still continuous. The World Health Organization data shows that the global accumulation of confirmed diagnosis has exceeded 51 million, and more than 1.27 million people have killed.[0003]The new crown virus is a new virus belonging to the coronary virus. It has a certain simi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61P31/14A61P1/00A61P11/00A23L29/00A23L33/10A61K31/704
CPCA61K38/47A61K31/704A61P31/14C12Y302/01017A61P1/00A61P11/00A23L29/06A23L33/10A23V2002/00A23L33/125A23L33/18A61K2300/00A23V2200/30A23V2200/314A23V2200/32A23L33/105A23L33/17A61K9/0043A61K9/08A61K9/145A61K38/19A61K45/06A61K47/02C12N9/2462
Inventor 孙明杰孙天宇李苌清
Owner GUANGZHOU CENTURY CLINICAL RES CO LTD
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