Application of Wangshi Baochi pills in preparation of medicine for preventing and/or treating alcoholic liver injury

A technology of alcoholic liver injury and Wangshi Baochi pills, which is applied in the field of medicine, can solve the problems of unreported applications, achieve the effects of improving pathological changes, increasing content, and shortening the time for sobering up

Active Publication Date: 2021-05-18
JINGHUA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the application of Wangshi Baochi Pills in the preparation of drugs for the prevention and / or treatment of alcoholic liver injury

Method used

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  • Application of Wangshi Baochi pills in preparation of medicine for preventing and/or treating alcoholic liver injury
  • Application of Wangshi Baochi pills in preparation of medicine for preventing and/or treating alcoholic liver injury
  • Application of Wangshi Baochi pills in preparation of medicine for preventing and/or treating alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental Example 1: Effects of Different Drugs on the Liver of Acute Alcohol Injury Model Mice

[0036] 1.1 Experimental materials

[0037] 1.1.1 Experimental animals

[0038] Male C57BL / 6 mice, weighing 18-22 g, SPF grade, were purchased from Changzhou Cavens Experimental Animal Co., Ltd.

[0039] 1.1.2 Main Drugs and Reagents

[0040] 1) Wangshi Baochi Wan powder, obtained by pulverizing Wangshi Baochi Wan purchased from Jinghua Pharmaceutical Group Co., Ltd.;

[0041] 2) Silybin, purchased from Tianjin Tasly Pharmaceutical Co., Ltd.;

[0042] 3) Detection kits: ADH kit, AST kit, ALT kit, GSH kit, SOD kit, purchased from Shanghai Enzyme Biotechnology Co., Ltd.

[0043] 1.2 Experimental method

[0044] 1.2.1 Statistics of drunken time of mice

[0045] Eighteen C57BL / 6 male mice were adaptively fed for one week and randomly divided into three groups: model group (Model), Wangshi Baochi pill group (WSBC), and silybin group (Silybin). Group 6. After the groupi...

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Abstract

The invention relates to application of Wangshi Baochi pills in preparation of a medicine for preventing and / or treating alcoholic liver injury, and belongs to the technical field of medicines. The application of the Wangshi Baochi pills in preparation of the medicine for preventing and / or treating alcoholic liver injury is provided, and researches find that the Wangshi Baochi pills can remarkably shorten the sobering time of drunken mice and reduce the levels of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase in serum of acute alcoholic liver injury modeling mice, can significantly improve the pathological change of liver tissue of the acute alcoholic liver injury modeling mice, can significantly reduce the expression of active oxygen in the liver tissue of the acute alcoholic liver injury modeling mice, and can significantly improve the activity of superoxide dismutase and the level of glutathione in the liver tissue of the acute alcoholic liver injury modeling mice, and in addition, the Wangshi Baochi pills can increase the expression of quinone oxidoreductase in liver tissue of the acute alcoholic liver injury modeling mice and have a good alcoholic liver injury relieving effect.

Description

technical field [0001] The invention relates to the application of Wangshi Baochi pills in the preparation of medicines for preventing and / or treating alcoholic liver injury, and belongs to the technical field of medicines. Background technique [0002] In recent years, with the continuous improvement of people's living standards, the per capita consumption of alcohol in my country has increased significantly, and the incidence of alcohol-related organ damage diseases has also increased year by year. [0003] The liver is one of the important target organs of alcohol injury. A large number of studies have clarified the injury pathway and mechanism of alcohol-endotoxin-Kupffer cells-TNFα and other cytokines-hepatic inflammation. Studies have also found that hepatic macrophages (Kupffer cells) are the main cells for endotoxin detoxification and the target cells attacked by endotoxins. In addition to interfering with cellular energy metabolism and intracellular signal transduct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P1/16A61P39/00
CPCA61K36/708A61K36/718A61K36/8884A61K36/8966A61P1/16A61P39/00A61K2300/00
Inventor 周云中曹鹏薛红卫叶娟王兆龙徐佳佳吴迪
Owner JINGHUA PHARMA GRP
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