Use of nano enzyme-based material

A technology based on materials and nanozymes, which is applied in the application field of nanozyme-based materials, and can solve problems such as high difficulty, induced stability and biological toxicity, and poor stability

Inactive Publication Date: 2021-05-18
景香香 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Not only the preparation cost is high, the difficulty is high, and the stability is poor, but also it is degraded into toxic organic substances in vivo, which seriously induces potential

Method used

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  • Use of nano enzyme-based material
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  • Use of nano enzyme-based material

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preparation example Construction

[0042] In the present invention, the preparation method of the nano enzyme-based material comprises the following steps:

[0043] SiO 2 @TiO 2 Colloidal solution of nanoparticles and CuCl 2 2H 2 O solutions were mixed and centrifuged to obtain SiO 2 @CuO x / TiO 2 Nanoparticles;

[0044] Adsorb polyvinylpyrrolidone on the SiO 2 @CuO x / TiO 2 Nanoparticles, centrifuged, dispersed in ethanol-water mixed solution, then added ammonia and tetraethyl orthosilicate, reacted, washed and centrifuged to form SiO 2 Overlay, dry, grind to get SiO 2 @CuO x / TiO 2 @SiO 2 Nano powder;

[0045] Calcinate the nanopowder, etch SiO after cooling to room temperature 2 , to get Cu / TiO 2 Nanozyme-based materials.

[0046] In the present invention, SiO 2 @TiO 2 Colloidal solution of nanoparticles and CuCl 2 2H 2 O solutions were mixed and centrifuged to obtain SiO 2 @CuO x / TiO 2 Nanoparticles. The present invention adjusts the local metal atom configuration through the follo...

Embodiment 1

[0061] 1. Synthesis of silica nanoparticles: follow Methods Preparation of spherical SiO by sol-gel method 2 Nanoparticles. To a solution containing ethanol (23 ml), water (4.3 ml) and ammonia (0.6 ml) was added 0.86 ml of tetraethyl orthosilicate (TEOS) at room temperature. The mixture was then stirred on a magnetic stirrer for 6 h. The reaction product was centrifuged, washed with water and ethanol, and dispersed in ethanol.

[0062] 2. Use TiO 2 coated SiO 2 Nanoparticles (SiO 2 @TiO 2 ): on SiO 2 The particles are coated with TiO 2 . The prepared SiO 2 The particles were dispersed in 40ml of absolute ethanol. Then, mix 14ml of pure acetonitrile and 0.4ml of ammonia (28-30wt%) into the SiO 2 The nanoparticle solution, referred to as solution 1. Solution 1 was sonicated for 10 min to obtain uniformly dispersed SiO 2Nanoparticles.

[0063] Meanwhile, 0.8 mL of titanium(IV) n-butoxane (TBOT) was dissolved in a mixture containing 6 ml of absolute ethanol and 2 m...

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Abstract

The invention provides use of a nano enzyme-based material as a sound-sensitive agent in sonodynamic force. The nano enzyme-based material comprises TiO2 nano particles and Cu single atoms anchored on the TiO2 nanoparticles. Under fluorescence imaging navigation of Cu/TiO2 in vivo, the Cu atoms in a static state are reduced to Cu <1+> in an activated state by activating electrons (e<->) on a surface of a TiO2 substrate through ultrasonic irradiation, H2O2 occupies binding sites of the Cu single atoms when the TiO2 substrate is exposed in a tumor microenvironment of over-expression H2O2, such that a catalytic performance induced by the Cu <1+> is enhanced and precise treatment is realized in cooperation with SDT. The Cu/TiO2 has high-catalytic-activity monatomic nano-enzyme characteristics while realizing molecular imaging diagnosis, such that a catalytic activity is greatly improved. A novel, efficient, small-side-effect and visualized diagnosis and precise treatment integrated novel treatment mode is provided for patients with breast cancer.

Description

technical field [0001] The invention belongs to the technical field of sound sensitizers, and in particular relates to the application of a nano-enzyme-based material. Background technique [0002] With the rapid development of nanoscience and nanotechnology, due to the full exposure of atomically active metal centers, single-atom nanozymes have good catalytic efficiency, maximum utilization of metal atoms, high activity and good recycling performance, and have attracted a lot of research scholars. s concern. Nanozymes have been widely used to treat reactive oxygen species (ROS)-related diseases, but as a major challenge, the exploration of catalytic activity for clinical applications is still in progress. [0003] Yan and his team developed a nanozyme-based single-atom catalytic bandage Pt / CeO 2 , for non-invasive treatment of neurotrauma, the nanozyme bandage can protect neurons by scavenging ROS and reducing inflammation in neuronal systems after traumatic brain injury....

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/32A61P35/00B82Y5/00B82Y30/00B82Y40/00
CPCA61K9/5138A61K41/0033A61P35/00B82Y5/00B82Y30/00B82Y40/00
Inventor 景香香陈其青杨大艳张敏冯桂英谢琳
Owner 景香香
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