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Medicine for treating artery diseases and application thereof

A technology of use, medicine, applied in the field of medicine

Pending Publication Date: 2021-05-21
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Clinically, there is no preventive and therapeutic drug for aneurysm, intramural hematoma and arterial dissection. Except for surgical treatment, patients are in a state of no cure, so there is an urgent clinical need to be able to treat aneurysm, intramural hematoma and / or arterial dissection. Dissection of the drug, to provide patients with more treatment options

Method used

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  • Medicine for treating artery diseases and application thereof
  • Medicine for treating artery diseases and application thereof
  • Medicine for treating artery diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0137] Preparation of aneurysm, interhematoma and or arterial dissection models

[0138] The mice were anesthetized by intraperitoneal injection of 1% sodium pentobarbital at a dose of 20 mg / kg according to the body weight of the mice. After waiting for the mouse to enter the anesthesia state, the abdominal hair was shaved off with a razor, and the hair was further thoroughly depilated with a depilatory cream. After the abdomen was wiped clean, it was fixed on the operating table, and a heating pad was used under the body to maintain body temperature. After wiping the skin of the abdomen with iodine, deiodine with 75% ethanol, cut an incision of about 1.5 cm in the center of the abdomen, carefully push away the viscera with forceps, and then divide the intestinal tract with gauze moistened with 3% penicillin-streptomycin. To the left and right sides, use forceps to carefully separate the connective tissue and muscle tissue on the surface of the aorta, so that the abdominal aor...

Embodiment 1

[0150] Preventive and therapeutic effects of ginsenoside Rg3 on aneurysm, intramural hematoma and / or arterial dissection

[0151] Animal administration and grouping situation: 30 8-week-old C57BL / 6 mice entered the animal room to adapt to feeding for one week, and then were randomly divided into normal control group, model control group and ginsenoside Rg3 group (n=10 in each group). Create models with pancreatic elastase and feed them with feed containing 1% β-aminopropionitrile on the day of modeling to induce aneurysm, intramural hematoma and arterial dissection. Administer physiological saline or ginsenoside Rg3 by intraperitoneal injection, the dosage of ginsenoside Rg3 is 100 mg / kg, continue to administer for 10 days and closely observe the activity of animals, and obtain the results after euthanizing the animals on the 15th day. Arterial tissue was evaluated for aneurysms, intramural hematomas, and arterial dissections.

[0152] Using porcine pancreatic elastase and 1%...

Embodiment 2

[0155] Preventive and therapeutic effects of ginsenoside Rh2 on aneurysm, intramural hematoma and / or arterial dissection

[0156] 2.1 Preventive and therapeutic effects of ginsenoside Rh2 on aneurysms

[0157] Animal administration and grouping: 30 8-week-old C57BL / 6 mice entered the animal room to adapt to feeding for one week, and then were randomly divided into normal control group, model control group and ginsenoside Rh2 group (n=10 in each group), porcine pancreas The day of elastase-induced aneurysm operation was Day 0. From the fifth day, the animals were given normal saline or ginsenoside Rh2 by intraperitoneal injection, and the dose of ginsenoside Rh2 was 100 mg / kg. After 10 days, the animal's activities were closely observed. On the 15th day, after the animal was euthanized, arterial tissue was obtained to evaluate the expansion of the aneurysm.

[0158] In this example, the mouse model of porcine pancreatic elastase-induced aneurysms corresponds to the early and m...

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Abstract

The invention provides a medicine for treating artery related diseases and application thereof. Specifically, the invention provides application of a compound shown as a formula I in treatment of artery-related diseases, and each group is defined in the specification. Experiments show that the compound in the formula I has remarkable curative effects on the artery diseases such as aneurysm, interwall hematoma and / or arterial dissection.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to medicines for treating arterial lesions and applications thereof. Background technique [0002] Aneurysm, intramural hematoma, and arterial dissection are interrelated and independent diseases that can occur in thoracic aorta, abdominal aorta, splenic artery, hepatic artery, superior mesenteric artery, celiac artery, renal artery, omental artery, Inferior mesenteric artery, intracranial artery and carotid artery etc. The development of these diseases all lead to blood vessel rupture in the later stage, endangering the patient's life. The etiology of aneurysm, intramural hematoma and arterial dissection is very complex, manifested as degradation of extracellular matrix in the media and adventitia, thinning of the arterial wall and invasion of inflammatory cells, smoking, hypertension and atherosclerosis are the most common predisposing factors. As the disease progresses, ves...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/575A61K45/06A61K31/4178A61K31/41A61K31/4184A61P9/14A61K36/258A23L33/00
CPCA61K31/704A61K31/575A61K45/06A61K31/4178A61K31/41A61K31/4184A61P9/14A61K36/258A23L33/00A23V2002/00A61K2300/00A23V2200/326
Inventor 姜宝红丁玉超张娴静
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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