Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quinoline derivative as well as preparation method and application thereof

A derivative, quinoline technology, applied in the field of quinoline derivatives and their preparation, can solve the problems of limitations, lack of universality, quinoline derivative fluorescein cannot be used to label small molecular compounds, etc., and meet the reaction conditions Mild, broadened selection range, and stable fluorescence properties

Inactive Publication Date: 2021-05-21
CHINA AGRI UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these quinoline derivative fluoresceins cannot be used to label commonly used small molecular compounds or biological macromolecules such as proteins, so they are not universal and have great limitations in the fields of immunoassay and small molecule detection.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quinoline derivative as well as preparation method and application thereof
  • Quinoline derivative as well as preparation method and application thereof
  • Quinoline derivative as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] This embodiment provides a quinoline derivative of the present invention and a preparation method thereof.

[0073] Concrete preparation steps are as follows:

[0074] (1) 4-benzoyl butyric acid is subjected to amidation reaction to obtain compound I:

[0075] Dissolve 119g (100mmol) of 4-benzoylbutyric acid in 500mL of dichloromethane (DCM), then add 8.97g (110mmol) of dimethylamine hydrochloride, 50mL of N,N-diisopropylethylamine (DIPEA ), 41.80g (110mmol) tetramethylurea hexafluorophosphate (HATU), stirred at room temperature 25°C for 16h, after the reaction, washed with 500mL water each time, repeated twice, then dried with anhydrous sodium sulfate, centrifuged The precipitated substance was taken and separated by thin-layer chromatography (the developing solvent was dichloromethane / methanol (v / v, 50:1)) to obtain 14.25 g of compound I with a yield of 65%.

[0076] (2) subjecting the compound I to an oximation reaction to obtain compound II;

[0077] 14.25g (65mm...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of chemical engineering, and particularly discloses a quinoline derivative as well as a preparation method and application thereof. The quinoline derivative has the following structure: the surface of the quinoline derivative has a high-activity carboxyl group which can be directly used for marking, and the quinoline derivative has a blue emission wavelength, so that the blank of the conventional organic dye fluorescein in a low wavelength band at present is filled, and the fluorescein selection range of multiple marking modes is widened. In addition, the quinoline derivative has good light stability, is stable in an organic reagent, can maintain good fluorescence characteristics, and is suitable for labeling reaction in an organic solvent. The preparation method of the quinoline derivative comprises the following steps: carrying out amidation, oximation and reduction reaction on 4-benzoylbutyric acid, firstly synthesizing a side chain of the quinoline derivative, and then carrying out condensation reaction on the side chain and 6-bromoquinoline to synthesize the final quinoline derivative. The method is simple and mild.

Description

technical field [0001] The invention relates to the technical field of chemical industry, in particular to a quinoline derivative and its preparation method and application. Background technique [0002] The parent structure of quinoline derivatives is quinoline, which was first isolated from coal tar. Quinoline derivatives are a very important class of heterocyclic compounds. Due to their obvious pharmacological and biological activities, they have been widely used in the fields of drug screening, dye industry and chemical analysis. A large number of studies have shown that many compounds with quinoline rings have obvious biological and pharmacological activities such as antibacterial, bactericidal, analgesic, antiallergic, antimalarial, antitumor, anticancer, antihypertensive, antidepressant and memory enhancement, and In recent years, quinoline derivatives have also been used to develop drugs for the treatment of AIDS. In addition, due to the excellent optical propertie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/38C09K11/06G01N21/64
CPCC07D215/38C09K11/06C09K2211/1007C09K2211/1029G01N21/6428G01N21/643G01N2021/6439
Inventor 王战辉温凯沈建忠张会艳于雪芝余文博史为民张素霞
Owner CHINA AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com