A kind of functionalized polyurethane and its preparation method and application

Abstract

The invention provides a functionalized polyurethane, which is obtained by copolymerizing a soft segment composed of polycarbonate diol and polyisobutylene diol with a rigid segment composed of diisocyanate and a chain extender; the chain extender includes Part A and component B; the component A is a diol containing 4-benzocyclobutenyl structure; the component B is other low-molecular-weight diols and / or low-molecular-weight diamines. The polycarbonate structure in the functionalized polyurethane soft segment provided by the present invention has a hydrolysis-resistant function, the polyisobutylene structure has an oxidation-resistant function, and the 4-benzocyclobutene-based structure in the rigid segment chain extender can be used at elevated temperatures (preferably high At 190°C), a self-crosslinking reaction occurs. Therefore, the functionalized polyurethane has good hydrolysis resistance, oxidation resistance, and creep resistance, which can realize the durability of medical polyurethane in vivo and be used to make artificial heart valves, artificial blood vessels, and interventional medical catheters for long-term implantation in the body.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a functionalized polyurethane and its preparation method and application. Background technique [0002] Medical polyurethane elastomer is composed of polyether, polyester diol, etc. as the soft segment, and diisocyanate as the hard segment. The flexibility of the soft segment endows polyurethane with good elasticity, and the rigidity of the hard segment forms a crystalline area. The soft segment and the hard segment The segment is a thermodynamically incompatible system, and there is a difference in polarity, which can cause microphase separation. By adjusting the ratio, structure, and molecular distribution of soft and hard segments, the polyurethane material can obtain suitable characteristics such as mechanical strength, wear resistance, resilience, biocompatibility, and anticoagulation. Medical polyurethane can be used in implanted medical devices, such as central ...

AI Technical Summary

Problems solved by technology

Due to the existence of ester groups, carbamate groups and urea groups in polyurethane, water will cause the hydrolysis of polyurethane molecular chains in the complex environment of the human body; the substances released by macrophages include H + Oxidation media such as enzymes, free radicals in the body can easily cause oxidative degradation of polyurethane. The degradation of polyurethane molecular chains caused by the above-mentioned hydrolysis and oxidation reactions leads to a decrease in its mechanical properties, and it is difficult to apply to long-term implanted / inserted devices in the human environment.

In addition, if polyurethane materials and products are used in long-term implanted devices, they will suffer from long-term fatigue stress and cause creep, which will also limit their further application.

Images