Microneedle patch loaded with copper ion doped polydopamine as well as preparation method and application of microneedle patch

A technology of polydopamine and microneedle sticking, which is applied in the direction of microneedles, medical preparations with no active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of difficult control of the amount of coating drugs, complicated preparation process, and skin inflammation. Response and other issues, to achieve rapid and precise drug release, easy large-scale preparation, and reproducible and strong effects

Active Publication Date: 2021-05-28
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the drug coating is not easy to stick to the surface of the microneedles, it is often necessary to add viscosity enhancers or surfactants to the drug coating, which not only complicates the preparation process, but more importantly, the amount of drug in the coating is difficult to control and cannot be given accurately. medicine
In addition, solid silicon or stainless steel as needle material may cause skin inflammation

Method used

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  • Microneedle patch loaded with copper ion doped polydopamine as well as preparation method and application of microneedle patch
  • Microneedle patch loaded with copper ion doped polydopamine as well as preparation method and application of microneedle patch
  • Microneedle patch loaded with copper ion doped polydopamine as well as preparation method and application of microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Such as figure 1 As shown, the preparation method of the copper ion-doped polydopamine-loaded microneedle patch of the present embodiment comprises the following steps:

[0038] (1) The 10% (w / v) polyvinylpyrrolidone hydrogel dispersed with copper ions doped polydopamine with a particle size of 100nm is spread into the PDMS microneedle template, and vacuumized at -0.04MPa vacuum degree After 3 minutes of down treatment, remove the excess polyvinylpyrrolidone hydrogel in the template; vacuumize again, and treat it at -0.06MPa vacuum for 3 minutes to obtain a hollow water-soluble shell;

[0039] (2) Spread polycaprolactone powder with a molecular weight of 2000 in the PDMS microneedle template, put it in an oven and heat it at 60°C for 15 minutes to melt the polycaprolactone into the cavity of the microneedle, and remove the excess polycaprolactone in the template. Caprolactone, resulting in a microneedle tip composed of a water-soluble shell and a hydrophobic core;

[...

Embodiment 2

[0045] The preparation method of the copper ion-doped polydopamine-loaded microneedle patch of the present embodiment comprises the following steps:

[0046] (1) The 20% (w / v) polyvinylpyrrolidone hydrogel that is dispersed with the copper ion doping polydopamine that particle size is 120nm spreads in the PDMS microneedle template, by vacuumizing, at -0.05MPa vacuum degree After processing for 3 minutes, remove the excess PDMS in the template; vacuumize again, and process for 5 minutes at a vacuum of -0.06MPa;

[0047] (2) Spread polycaprolactone powder with a molecular weight of 5000 in the PDMS microneedle template, put it in an oven and heat it at 70°C for 15 minutes, so that the polycaprolactone melts and flows into the cavity of the microneedle, and the excess polycaprolactone in the template is removed. Caprolactone;

[0048] (3) Lay 30% (w / v) polyvinylpyrrolidone hydrogel (wherein the molecular weight of polyvinylpyrrolidone is 500000) in the PDMS microneedle template,...

Embodiment 3

[0051] The preparation method of the copper ion-doped polydopamine-loaded microneedle patch of the present embodiment comprises the following steps:

[0052] (1) The 30% (w / v) polyvinylpyrrolidone hydrogel dispersed with copper ions doped polydopamine with a particle size of 80nm is spread into the PDMS microneedle template, and vacuumized at -0.08MPa vacuum degree After 3 minutes of down treatment, remove the excess polyvinylpyrrolidone hydrogel in the template; vacuumize again, and treat it at -0.08MPa vacuum for 5 minutes;

[0053] (2) Spread polycaprolactone powder with a molecular weight of 10,000 in the PDMS microneedle template, put it in an oven and heat it at 80°C for 15 minutes, so that the polycaprolactone melts and flows into the cavity of the microneedle, and removes the excess polycaprolactone in the template. Caprolactone;

[0054] (3) Spread 30wt% polyvinylpyrrolidone hydrogel (wherein, the molecular weight of polyvinylpyrrolidone is 2,000,000) in the PDMS mic...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a microneedle patch loaded with copper ions and doped with polydopamine as well as a preparation method and application of the microneedle patch. The microneedle patch comprises a substrate and a microneedle head attached to the substrate, the microneedle head is of a core-shell structure and comprises a hydrophobic core and a water-soluble shell covering the hydrophobic core, and the water-soluble shell contains copper ion doped polydopamine. Growth of skin superficial tumors is inhibited by means of good transdermal property of the microneedle array, photothermal effect of copper ion doped polydopamine and toxic free hydroxyl generated through active oxygen mediation, advantages of the coating microneedle are met, defects of the coating microneedle are overcome, the coating microneedle has the advantage of being capable of rapidly and accurately releasing medicine, and the application range of the coating microneedle is widened. The defect that in the dip-coating or spraying process of an existing coating microneedle array, oxygen plasma treatment needs to be carried out on a microneedle body material or a viscosity enhancer or a surfactant needs to be added into a medicine is overcome, and skin inflammation can be avoided.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a microneedle patch loaded with copper ions doped with polydopamine, a preparation method and application thereof. Background technique [0002] In recent years, the emerging microneedle transdermal drug delivery system can effectively avoid multiple transport barriers such as extreme pH of gastric acid, degradation of digestive enzymes, clearance by intestinal peristalsis, and intestinal epithelial transport, especially for the delivery of macromolecular drugs. As a new type of minimally invasive transdermal drug delivery tool in the field of biomedicine, microneedles have been widely used in the field of transdermal drug delivery due to their advantages such as minimally invasive, painless, safe, efficient, and easy to use. [0003] Coated microneedles can rapidly release the microneedle array of drugs coated on the needle outer layer. Although the surface area ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K41/00A61K47/32A61K47/34A61M37/00A61P35/00
CPCA61K9/0021A61K41/0052A61K47/32A61K47/34A61P35/00A61M37/0015A61M2037/0053Y02A50/30
Inventor 江国华宋高刘天琦张雪雅曾志勇
Owner ZHEJIANG SCI-TECH UNIV
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