Synthesis method of O-(3-chloro-2-propenyl) hydroxylamine

A synthetic method and propylene-based technology, applied in the direction of hydroxylamine, chemical instruments and methods, nitrogen compounds, etc., can solve the problems of large amount of three wastes, low production efficiency, inconvenient industrialization, etc., to reduce salt content, improve product yield and quality, and the effect of reducing the cost of wastewater treatment
CN112851544APending Publication Date: 2021-05-28SHANGHAI DONGGENG CHEM TECH CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANGHAI DONGGENG CHEM TECH CO LTD
Publication Date
2021-05-28

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Abstract

The invention belongs to the technical field of organic synthesis, and particularly discloses a synthesis method of O-(3-chloro-2-propenyl) hydroxylamine. The synthesis method comprises the following steps of: carrying out a heating reaction on a hydroxylamine solution and methyl isobutyl ketone to obtain methyl isobutyl ketoxime, then carrying out a reaction on the methyl isobutyl ketoxime, 1, 3-dichloropropene and an alkali liquor, after the reaction is finished, adjusting the reaction liquid to be weakly acidic by using acid, carrying out phase splitting, extracting a water phase by using methyl isobutyl ketone, combining organic phases, washing with water, removing water, and recovering the methyl isobutyl ketone to obtain the product 0-(3-chloro-2-propenyl) hydroxylamine. According to the method, methyl isobutyl ketone serves as an amino protective agent and a solvent at the same time, the molecular structure is not changed before and after the reaction, the defects that a large amount of ethyl acetate is consumed and acetic acid and sodium chloride are produced as byproducts in a traditional process can be overcome, and the method is an efficient, environment-friendly and high-yield 0-(3-chloro-2-propenyl) hydroxylamine synthesis method and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to the technical field of organic synthesis, in particular to a method for synthesizing a pesticide intermediate O-(3-chloro-2-propenyl)hydroxylamine. Background technique

[0002] O-(3-chloro-2-propenyl)hydroxylamine (chlorinated amine) belongs to alkoxyamine compounds, which are widely used and expensive organic synthesis intermediates. Alkoxyamine compounds can be used as alkyl amination reagents, introducing alkoxyamine groups to ketone compounds (especially steroids) in organic synthesis and new drug production, and can be used as intermediates in drug production , can also be used as an intermediate in the field of synthesis of new medicines and new pesticides. O-(3-chloro-2-propenyl) hydroxylamine is an important intermediate of clethodim, and can also be widely used in the synthesis of other cyclohexenones Oxime herbicides, such as Tepraloxydim, Cycloxydim, Tralkoxydim, Butroxydim, Clefoxidim, etc. This type of herbicide...

Claims

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