Quality control method of substance reference of Linggui curcuma zedoary decoction

A quality control method and technology of Lingguishu, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems such as the standard quality control method of Lingguizhugan decoction, which is simple, high precision and good stability. Effect

Pending Publication Date: 2021-06-04
ZHONGJING WANXI PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, there is no quality control method li

Method used

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  • Quality control method of substance reference of Linggui curcuma zedoary decoction
  • Quality control method of substance reference of Linggui curcuma zedoary decoction
  • Quality control method of substance reference of Linggui curcuma zedoary decoction

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0040] 1. Instruments and materials

[0041] 1.1 Experimental Instruments

[0042] Waters e2695 high performance liquid chromatography (Waters Technology Co., Ltd., USA), KQ-500DE numerical control ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.), MS105 electronic analytical balance (Mettler-Toledo Instrument Co., Ltd.), UPT-Ⅱ-10T Youpu ultrapure water machine (Chengdu Ultrapure Technology Co., Ltd.).

[0043] 1.2 Experimental reagents and materials

[0044] Liquiritin (batch number 111610-201908, content 95.0%), cinnamic acid (batch number 110786-201604, content 98.8%), monoammonium glycyrrhizinate (batch number 110713-201619, content 93.0%), atractylodes lactone Ⅲ ( Batch number 110978-201501, the content is 99.9%), all of which were purchased from China National Institutes for Food and Drug Control.

[0045] Methanol, acetonitrile, glacial acetic acid, formic acid, and phosphoric acid were chromatographically pure, the rest of the reagents were analytically p...

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Abstract

The invention relates to a quality control method of a substance reference of a Linggui curcuma zedoary decoction. The method comprises an HPLC content determination method for simultaneously determining four components of liquiritin, cinnamic acid, ammonium glycyrrhizinate and atractylenolide III of the substance reference of the Linggui curcuma zedoary decoction and an HPLC characteristic chromatogram of the substance reference of the Linggui curcuma zedoary decoction. According to the structural characteristics of the active ingredients contained in the Linggui curcuma zedoary decoction, the optimal mobile phase composition, gradient elution procedure, flow velocity, detection wavelength, chromatographic column, column temperature and other analysis conditions are screened out through a large number of experiments, the method for detecting the quality of the Linggui curcuma zedoary decoction can comprehensively, objectively and accurately detect and evaluate the quality of the Linggui curcuma zedoary decoction material reference and the preparation thereof, has important significance for ensuring the clinical curative effect of the Linggui curcuma zedoary decoction material reference, and provides a reliable quality attribute research method and evaluation system for the classical famous prescription Linggui curcuma zedoary decoction material reference and the preparation of the classical famous prescription Linggui curcuma zedoary decoction material reference.

Description

[0001] 1. Technical field [0002] The invention relates to the technical field of traditional Chinese medicines, in particular to a quality control method of Linggui Zhugan Decoction substance reference. [0003] 2. Background technology [0004] Linggui Zhugan Decoction is a classic famous prescription, which originated from Zhang Zhongjing's "Synopsis of the Golden Chamber". The effect of drinking, invigorating the spleen and promoting dampness is the ancestral prescription for treating phlegm and retention. Clinically, it has a good therapeutic effect on cardiovascular diseases, chronic bronchitis, Meniere's disease, chronic bronchitis and other diseases. [0005] The present invention adopts high-performance liquid chromatography to establish the characteristic spectrum of Linggui Zhugan Decoction material reference and the quality detection method of simultaneous determination of multiple components, and the active ingredients Liquiritin, cinnamic acid, ammonium glycyrrh...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/14G01N30/36G01N30/54G01N30/74
CPCG01N30/02G01N30/06G01N30/14G01N30/36G01N30/54G01N30/74G01N2030/027G01N2030/062
Inventor 郭水柱周改敏陈娜娜
Owner ZHONGJING WANXI PHARMA CO LTD
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