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Biodegradable up-conversion core-shell nanocrystal and preparation method and application thereof

A core-shell nanometer and nanocrystal technology is applied in the field of nanomaterials to achieve the effects of uniform particle size distribution, simple and easy method, and product purity and environmental protection.

Pending Publication Date: 2021-06-11
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, the scheme or route of preparing rare earth fluoride nanocrystals with strong up-conversion luminescence and biodegradable properties using near-infrared light as an excitation light source has not been reported yet.

Method used

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  • Biodegradable up-conversion core-shell nanocrystal and preparation method and application thereof
  • Biodegradable up-conversion core-shell nanocrystal and preparation method and application thereof
  • Biodegradable up-conversion core-shell nanocrystal and preparation method and application thereof

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Experimental program
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Embodiment 1

[0031] This embodiment provides a method for preparing biodegradable upconversion core-shell nanocrystals, comprising the following steps:

[0032] (1) Synthesize trifluoroacetate and zirconium acetate of metal elements ytterbium and erbium respectively: at room temperature, mix 10mmol rare earth oxide and 60mmol trifluoroacetic acid in a container, and slowly heat the mixed solution to 80°C under stirring , add 10mL of distilled water and continue to react for 0.5h, cool the obtained solution and filter to obtain a clear and transparent solution, continue to heat at 80°C until trifluoroacetic acid compound crystals are precipitated on the surface of the solution, transfer to a 60°C oven for drying, and the obtained solid powder is The trifluoroacetate of the corresponding rare earth elements; slowly heat 25mL of zirconium acetate solution with a concentration of 15% to 16%, until zirconium acetate crystals are precipitated on the surface of the solution, transfer to a 60°C ove...

Embodiment 2

[0037] This embodiment provides a method for preparing biodegradable upconversion core-shell nanocrystals, comprising the following steps:

[0038] (1) Synthesize trifluoroacetate and zirconium acetate of metal elements ytterbium and erbium respectively: at room temperature, mix 30mmol rare earth oxide and 180mmol trifluoroacetic acid in a container, and slowly heat the mixed solution to 80°C under stirring , add 5mL of distilled water and continue to react for 0.8h, cool the obtained solution and filter to obtain a clear and transparent solution, continue to heat at 60°C until trifluoroacetic acid compound crystals are precipitated on the surface of the solution, transfer to a 65°C oven for drying, and the obtained solid powder is The trifluoroacetate of the corresponding rare earth element; 20mL of zirconium acetate solution with a concentration of 15% is slowly heated until zirconium acetate crystals are precipitated on the surface of the solution, transferred to a 70°C oven...

Embodiment 3

[0042] This embodiment provides a method for preparing biodegradable upconversion core-shell nanocrystals, comprising the following steps:

[0043] (1) Synthesize trifluoroacetate and zirconium acetate of metal elements ytterbium and erbium respectively: at room temperature, take 20mmol rare earth oxide and 120mmol trifluoroacetic acid and mix them uniformly in a container, and slowly heat the mixed solution to 60°C under stirring , add 20mL of distilled water and continue to react for 1h, cool the obtained solution and filter to obtain a clear and transparent solution, continue to heat at 100°C until trifluoroacetic acid compound crystals are precipitated on the surface of the solution, transfer to an oven at 80°C for drying, and the obtained solid powder is the corresponding Trifluoroacetate of rare earth elements; slowly heat 30mL of zirconium acetate solution with a concentration of 15% to 16%, until zirconium acetate crystals are precipitated on the surface of the solution...

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Abstract

The invention discloses a biodegradable up-conversion core-shell nanocrystal and a preparation method and application thereof, and relates to the technical field of nanomaterials. The chemical expression of the nanocrystal is Na3ZrF7: Yb, Er (at) CaF2, Yb, and in the formula, (at) represents coating; the preparation method comprises the following steps: firstly, generating the rare earth doped zirconium fluoride-based core nanocrystal with uniform particle size distribution by adopting a high-temperature solvothermal method, and then coating the core nanocrystal with the CaF2-based shell layer by adopting an epitaxial growth method, thereby obtaining the core-shell structure nanomaterial with stronger red up-conversion fluorescence and biodegradability. The core-shell structure nanocrystal is prepared by adopting a simple, feasible, green and environment-friendly high-temperature pyrolysis method, the prepared product has relatively strong red upconversion fluorescence and biodegradability at the same time, and the relatively strong upconversion fluorescence is beneficial to realizing a good optical imaging effect; meanwhile, due to the biodegradability, the up-conversion nanocrystal can be degraded into a metabolizable harmless product in a living body after exerting in-vivo diagnosis and treatment functions.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a biodegradable up-conversion core-shell nanocrystal, a preparation method and an application thereof. Background technique [0002] The upconversion luminescence process is an anti-Stokes process, which refers to the luminescence phenomenon in which two or more low-energy photons (usually near-infrared photons) are absorbed and converted into one high-energy photon. By converting the near-infrared photons that penetrate deep into biological tissues into visible or ultraviolet photons, the fluorescence signals of rare earth up-conversion nanocrystals can be detected and re-excited in deep tissues, making their in vivo biological applications possible. [0003] Rare-earth up-conversion nanocrystals have deep tissue penetration depth, low autofluorescence and excellent photobleaching resistance when applied to optical imaging. An extremely active and exciting research direct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/67B82Y20/00B82Y30/00
CPCC09K11/02C09K11/7773B82Y20/00B82Y30/00
Inventor 徐加廷吕武斌付玉杰王强李春生王军叶金王希清焦骄
Owner NORTHEAST FORESTRY UNIVERSITY
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