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Plug pin type soft tissue repair patch and preparation method thereof

A soft tissue and plug-in technology, applied in medical science, muscles, ligaments, etc., can solve the problems of immune rejection, cytotoxicity, low biological activity, etc., and achieve the effect of avoiding re-tearing, high healing strength, and strong holding force

Pending Publication Date: 2021-06-18
SHANGHAI SIXTH PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many materials used for rotator cuff repair, including biological source materials and artificial synthetic materials, but each has its own problems and application limitations in clinical application
The autologous tissue transplantation patch has good biocompatibility, but the material may cause trauma to the autologous tissue
However, the allogeneic patch lacks stable mechanical strength, resulting in immune rejection after transplantation, and there is a risk of infection and disease
Although decellularized tissue grafts have solved the problems of immunity and supply, they still have poor mechanical effects and cannot meet the mechanical load intensity after early rotator cuff repair
[0004] Artificially synthesized degradable patch materials include L-polylactic acid, lactic acid glycolic acid, polycaprolactone and polypropylene glycol copolymers, etc., which can provide a certain degree of mechanical strength, and the degradation products may have certain cytotoxicity and biological activity. lower
At present, the patches on the market are still not very good in terms of biocompatibility, mechanical strength, firm and reliable patch-bone fixation, etc., especially after the huge rotator cuff tear is effectively repaired, so the design is biocompatible. The artificial rotator cuff with good stability, sufficient mechanical strength, and the ability to reconstruct the tendon-bone insertion of the rotator cuff has important clinical application value for the treatment of huge rotator cuff injuries.

Method used

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  • Plug pin type soft tissue repair patch and preparation method thereof
  • Plug pin type soft tissue repair patch and preparation method thereof
  • Plug pin type soft tissue repair patch and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0040] On the other hand, the method for preparing the plug-in soft tissue repair patch includes the following steps:

[0041] Step 1: Weaving the electrospun composite material with highly imitated tendon fibers into a rectangular sheet-like structure, and dividing the rectangular sheet-like structure into a sheet-like part and a double-column part according to the length ratio;

[0042] Step 2: Apply artificial osteoinductive material evenly on the surface of the double columnar part, and then cut the double columnar part into two symmetrical parts;

[0043] Step 3, use the tendon wire to lock the above two parts along the cut gap, and then roll them to both sides to form a columnar structure.

[0044] In a preferred embodiment of the present invention, step 1 will use decellularized dermal matrix, collagen, silk fibroin, polypropylene, polyethylene, polylactic acid, polyglycolic acid, polycaprolactone, chitosan, etc. One or several mixed solutions are spun into a rectangu...

Embodiment 1

[0050] This embodiment provides a plug-type soft tissue repair patch, the main structure of which is a plug-type segmented structure, including a sheet-shaped part 1 and a double-column part 2 .

[0051] Among them, the sheet-like part 1 is a rectangular sheet-like structure with a thickness of about 1.5mm, which is made of acellular dermal matrix, collagen, silk fibroin, polypropylene, polyethylene, polylactic acid, polyglycolic acid, polycaprolactone , chitosan and other mixed solutions of one or more of them are woven by electrospinning technology, have certain mechanical strength, and are mainly used to bridge the tendon of the rotator cuff;

[0052] The double columnar part 2 is composed of two symmetrical columnar structures connected to one end of the sheet part 1, and is mainly used for anchoring in the bone tunnel part; it is made of acellular dermal matrix, collagen, silk fibroin, polypropylene, polypropylene A sheet-like composite material and heterogeneous (body) a...

Embodiment 2

[0064] In vitro osteoblast experiments on the cross-section of the double-column part of the plug-in soft tissue repair patch provided in Example 1:

[0065] Osteoblasts were co-cultured with plug-in soft tissue repair patch on the cross-section of the double columnar structure for 14 days, and alizarin staining was performed, as shown in Figure 4 As shown, the columnar part significantly promotes the mineralization of osteoblasts, which is conducive to the integration of tendon and bone after being pulled into the bone canal.

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Abstract

The invention provides a plug pin type soft tissue repair patch. The plug pin type soft tissue repair patch is of a highly-oriented three-dimensional net-shaped structure; the plug pin type soft tissue repair patch comprises a sheet-shaped part and a double-column-shaped part, wherein the sheet-shaped part is in a rectangular sheet shape formed by weaving an electrospinning composite material highly imitating the direction of tendon fibers and is used for bridging a rotator cuff tendon part; the double-column-shaped part is composed of two symmetrical column-shaped structures connected with one end of the sheet-shaped part and used for being anchored to a bone tunnel part; each columnar structure is formed by rolling a sheet-shaped electrospinning composite material and an artificial bone induction material, wherein the electrospinning composite material and the artificial bone induction material are uniformly distributed layer by layer in a concentric circle shape. The plug pin type soft tissue repair patch is in an integrated sectional type, so that bridging of the rotator cuff tendon tissue and the sheet-shaped part is realized, and mortise and tenon type fixation is formed by the double-column-shaped part and the bone tunnel. The holding force between the patch and the bone is strong, so that re-tearing caused by the fact that the traditional rotator cuff patch and the bone surface are fixed by using a sewing technology is avoided, and the problems of scar connection and poor mechanical property of tendon bones after conventional operation repair are solved.

Description

technical field [0001] The invention relates to the technical field of surgical patch repair, in particular to a plug-type soft tissue repair patch and a preparation method thereof. Background technique [0002] Rotator cuff injury is a relatively common injury in the field of orthopedic sports medicine, which often leads to shoulder joint pain, reduced range of motion, and weakened shoulder joint function. When the rotator cuff tear is greater than 5cm or the tear involves two tendons, the failure rate of the operation is still as high as 40%. The main reason is that large rotator cuff tears are often accompanied by muscle atrophy and degeneration, and it is difficult to pull the residual rotator cuff back to the footprint area. [0003] At present, there are many materials used for rotator cuff repair, including biological source materials and artificial synthetic materials, but each has its own problems and application limitations in clinical application. The autologous...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61F2/00
CPCA61F2/08A61F2/0063A61F2240/001
Inventor 赵金忠苏为蒋佳潘银根潘华倩杨中万吴锋郭凯捷康育豪徐俊杰
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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