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Anti-inflammatory and analgesic aerosol and preparation method thereof

An aerosol and gas-phase technology, applied in the field of medicine, can solve the problems of limited aerosol efficacy, aerosol consumption, gastrointestinal irritation, etc., and achieve the effects of improving anti-inflammatory and analgesic effects, reducing usage, and improving utilization rate

Active Publication Date: 2021-06-18
广东同德药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The aerosols in the above-mentioned technologies can effectively avoid various problems existing in oral medicines, etc., but overall, the anti-inflammatory and analgesic effects of aerosols still have certain limitations compared with oral or injection preparations. Therefore, there is often a serious problem of aerosol consumption during use
[0004] Aiming at the problems of gastrointestinal stimulation, liver first-pass effect, and aerosol aerosol in the prior art, there is an urgent need to find a product with good curative effect and quick effect, so as to make patients Get good treatment while avoiding excessive consumption of products

Method used

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  • Anti-inflammatory and analgesic aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An aerosol, consisting of a gas phase and a liquid phase at a weight ratio of 1:2, wherein the liquid phase includes the following raw materials: 10 parts of diclofenac sodium, 6 parts of laurocaprazine, 15 parts of propylene glycol, 25 parts of ethanol, 12 parts of Polyethylene glycol, 3 parts booster, and 5 parts peppermint oil. The synergist is Tween-80, folinic acid and propyl gallate in a weight ratio of 5:1:6. The gas phase is a propellant, and the propellant is propane.

[0027] The preparation method of above-mentioned aerosol, comprises the following steps:

[0028] (1) After pulverizing diclofenac sodium, add it to ethanol, stir and mix to obtain mixed solution A;

[0029] (2) Mix laurocapram, propylene glycol, ethanol, polyethylene glycol, synergist and peppermint oil evenly to obtain mixed solution B;

[0030] (3) After mixing the mixed solution A and the mixed solution B, shear and stir until the mixed solution is a micron-sized microemulsion solution, w...

Embodiment 2

[0033] An aerosol comprising a gaseous phase and a liquid phase at a weight ratio of 1:6, wherein the liquid phase comprises the following raw materials: 20 parts of diclofenac sodium, 11 parts of laurocaprazine, 20 parts of propylene glycol, 30 parts of ethanol, 22 parts of Polyethylene glycol, 8 parts booster, and 8 parts peppermint oil. The synergist is Tween-80, folinic acid and propyl gallate in a weight ratio of 10:1:9. The gas phase is the propellant, which is tetrafluoroethane.

[0034] The preparation method of above-mentioned aerosol, comprises the following steps:

[0035] (1) After pulverizing diclofenac sodium, add it to ethanol, stir and mix to obtain mixed solution A;

[0036] (2) Mix laurocapram, propylene glycol, ethanol, polyethylene glycol, synergist and peppermint oil evenly to obtain mixed solution B;

[0037] (3) After mixing the mixed solution A and the mixed solution B, shear and stir until the mixed solution is a micron-sized microemulsion solution,...

Embodiment 3

[0040] An aerosol, consisting of a gaseous phase and a liquid phase at a weight ratio of 1:5, wherein the liquid phase includes the following raw materials: 15 parts of diclofenac sodium, 9 parts of laurocaprazine, 16 parts of propylene glycol, 30 parts of ethanol, 18 parts of Polyethylene glycol, 5 parts booster, and 6 parts peppermint oil. The synergist is Tween-80, folinic acid and propyl gallate in a weight ratio of 8:1:8. The gas phase is the propellant, which is isobutane.

[0041] The preparation method of above-mentioned aerosol, comprises the following steps:

[0042] (1) After pulverizing diclofenac sodium, add it to ethanol, stir and mix to obtain mixed solution A;

[0043] (2) Mix laurocapram, propylene glycol, ethanol, polyethylene glycol, synergist and peppermint oil evenly to obtain mixed solution B;

[0044] (3) After mixing the mixed solution A and the mixed solution B, shear and stir until the mixed solution is a micron-sized microemulsion solution, wherei...

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Abstract

The invention provides an anti-inflammatory and analgesic aerosol and a preparation method thereof, and relates to the field of medicines. The aerosol is composed of a gas phase and a liquid phase, wherein the liquid phase comprises the following raw materials of diclofenac sodium, laurocapram, propylene glycol, ethyl alcohol, polyethylene glycol, a synergist and peppermint oil. A preparation method of the aerosol is simple, the prepared aerosol is good in curative effect and quick in effect, the aerosol can be prevented from being excessively consumed while a patient is well treated, and sports injuries or acute attacks of acute arthritis such as gout and degenerative arthritis can be effectively treated.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an anti-inflammatory and analgesic aerosol and a preparation method thereof. Background technique [0002] Diclofenac sodium is a new type of non-steroidal anti-inflammatory analgesic, which has good antipyretic and analgesic effects. Pain and fever of various causes. Diclofenac sodium anti-inflammatory and analgesic drugs have the advantages of good curative effect, small side effects, and no accumulation in long-term use among similar drugs. At present, there are many dosage forms of diclofenac sodium on the market, and they have better therapeutic effects. For example, diclofenac sodium oral tablet has better anti-inflammatory and analgesic effects, and diclofenac sodium gel has anti-inflammatory, anti-rheumatic, pain-relieving and antipyretic effects. effect. However, these different dosage forms have various disadvantages while exerting their effects, such as oral non-steroidal an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/22A61K47/10A61K47/26A61K47/12A61K47/14A61K47/44A61K31/196A61P29/00A61P19/02A61P19/06
CPCA61K9/12A61K47/22A61K47/10A61K47/26A61K47/12A61K47/14A61K47/44A61K31/196A61P29/00A61P19/02A61P19/06
Inventor 周小萍肖海文陈日宏雷春华陈其梓王明巧林文辉
Owner 广东同德药业有限公司
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