Medical application of aporphine alkaloid

Abstract

The invention discloses an application of aporphine alkaloid shown in a formula III in preparation of an antidepressant drug. R1 and R2 are respectively and independently selected from alkoxy and methylenedioxy, R3 and R4 are respectively and independently selected from H, OH, alkoxy and methylenedioxy, but when R3 and R4 cannot be H at the same time or R1 and R2 are both selected from methoxy, R3 cannot be OH, and R4 cannot be H. Pharmacological experiments show that the aporphine alkaloid shown in the formula III has a better anti-depression drug effect, and compared with fluoxetine, the aporphine alkaloid has a better anti-depression effect, a higher response rate and a faster effect.

Description

technical field

[0001] The invention belongs to the field of pharmacotherapeutics, and relates to the medical use of aporphil alkaloids, in particular to the use of aporphil alkaloids in antidepressants. Background technique

[0002] Depression is a kind of mental disorder with persistent depressed mood as the main clinical symptom. sense of worth, and even suicidal ideation and behavior when severe. Sometimes there are accompanying symptoms such as decreased energy, changes in appetite, more or less sleep, anxiety, decreased concentration, restlessness, etc. The etiology and pathogenesis of depression have not yet been fully elucidated. Low content of central norepinephrine, serotonin, dopamine and other monoamine neurotransmitters and low receptor function are considered to be the cause of depression.

[0003] Existing clinical antidepressants have disadvantages such as slow onset time, low response rate, and side effects (such as withdrawal effects, gastrointestinal sy...

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