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Shapeable bone sponge for orthopedic filling and preparation method thereof

A bone sponge and orthopedic technology, applied in the fields of medical science, tissue regeneration, prosthesis, etc., can solve the problems of difficult shaping of implants, slow crawling replacement, slow wound healing, etc., to achieve accelerated healing, good osteoinduction, immune The effect of low originality

Inactive Publication Date: 2021-06-22
山西奥瑞生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a plastic bone sponge for orthopedic filling and its preparation method, so as to solve the problem that the current implants are not easy to shape, slow to crawl and replace, and slow to absorb. , slow wound healing, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A plastic bone sponge for orthopedic filling, including bone sponge material, the bone sponge material includes cortical bone from the tibia or mid-section of femur obtained from a qualified human donor, and the above cortical bone is cleaned, degreased, and virus inactivated , demineralization, molding, freeze-drying, screening, viscosification, neutralization, centrifugation, irradiation and other processes.

[0031] In the present invention, the surface of the bone sponge material is densely covered with holes, which increase the surface area of ​​the material and provide more attachment points for the migration of cells; the holes make the material elastic, strong in plasticity, and can fit bone defects well; the holes Facilitate tissue growth and speed up the replacement by autologous tissue.

Embodiment 2

[0033] A method for preparing a plastic bone sponge for orthopedic filling, which includes the above-mentioned bone sponge material, and the preparation method includes cleaning, degreasing, virus inactivation, demineralization, fibrosis, freeze-drying, screening, viscosification, neutralization and, centrifugation, radiation sterilization process, the specific steps are as follows,

[0034] Step 1, cleaning: use human cortical bone as the raw material, take the midsection of the tibia or femur, and clean thoroughly until no adhesive components remain;

[0035] Step 2, degreasing: Mix chloroform solution and formaldehyde solution to prepare a degreasing solution, put the above-mentioned cleaned cortical bone into the degreasing solution, soak at room temperature for 24 hours to degrease, the volume of the solution is preferably to completely immerse the material;

[0036] Step 3, virus inactivation: soak the above degreased cortical bone in purified water, the temperature of t...

Embodiment 3

[0051]Before clinical use, the bone sponge material needs to be fully rehydrated with normal saline for more than 10 minutes, manually shaped according to clinical requirements, and then implanted into the bone defect;

[0052] The material of the present invention is a bone sponge material prepared from human cortical bone. After treatment, the immunogenicity is low, and it has good osteoinduction and osteoconduction, and has the characteristics of plasticity. The surface of the bone sponge material is densely covered with holes, which is conducive to osteogenesis. The entry of cells; the exposure of osteoinductive protein can promote the formation of bone tissue, accelerate the healing of bone defects, and has a good application prospect in orthopedic surgery.

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Abstract

The invention discloses shapeable bone sponge for orthopaedic filling and a preparation method thereof, wherein the shapeable bone sponge comprises a bone sponge material, and the bone sponge material comprises a cortical bone of the middle section of a tibia or a femur of a qualified human donor. The cortical bone is subjected to cleaning, degreasing, virus inactivation, demineralization, forming, freeze-drying, screening, viscidity, neutralization, centrifugation and irradiation sterilization to obtain the bone sponge material. The bone sponge material has the shapeable characteristic, and can be shaped at will according to the shape of a clinical bone defect; the reticular structure is beneficial to the entry of osteoblasts; the exposure of the bone induction protein can promote the formation of bone tissues; and the bone defect healing is accelerated, and good application prospects are achieved in the orthopedic surgery.

Description

technical field [0001] The invention relates to the technical field of biomaterials and orthopedic materials, in particular to a shapeable bone sponge for orthopedic filling and a preparation method thereof. Background technique [0002] Conditions such as trauma, infection, bone tumors, and osteomyelitis debridement may cause bone defects that are difficult to heal. Clinically, bone graft materials are often filled in the defect site to promote bone healing. Commonly used materials include autologous bone, allogeneic bone, and artificial bone. [0003] Since autologous bone comes from itself, it has good histocompatibility and will not cause rejection, but the source is limited and the acquisition process may cause complications at the graft donor site, and there is a risk of bone resorption. [0004] Artificial bone includes bone cement or bioceramics. Bone cement has good mechanical properties and has been used clinically for decades, but its shortcomings are also obvio...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/50A61L27/56
CPCA61L27/3608A61L27/365A61L27/3687A61L27/3691A61L27/50A61L27/56A61L2300/412A61L2430/02A61L2430/40
Inventor 任晓琦李晶杨婷乔玮李靖石浩赵亚平马绍英
Owner 山西奥瑞生物材料有限公司
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