Medical natural polymer microsphere containing radionuclides as well as preparation method and application of medical natural polymer microsphere

A technology of natural macromolecules and radionuclides is applied in the field of medical natural macromolecular microspheres containing radionuclides and their preparation, and achieves the effects of good biocompatibility, simple preparation method and high product purity

Active Publication Date: 2021-06-25
厦门宏谱福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the technical problems existing in the existing radioactive microspheres, the present invention aims to provide a medical natural polymer microsphere containing radionuclide and its preparation method and application

Method used

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  • Medical natural polymer microsphere containing radionuclides as well as preparation method and application of medical natural polymer microsphere
  • Medical natural polymer microsphere containing radionuclides as well as preparation method and application of medical natural polymer microsphere
  • Medical natural polymer microsphere containing radionuclides as well as preparation method and application of medical natural polymer microsphere

Examples

Experimental program
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Embodiment 1

[0046] Embodiment 1. Preparation of medical natural polymer microspheres

[0047] S1, weigh 5g of chitosan and dissolve it in 100mL of deionized water, mix well under ultrasonic and heating conditions, adjust the pH to 3 with 0.1M HCl, then add 10wt% NaIO to the reaction device 4 , at 40°C for 3 hours. After the reaction, add 10 mL of 0.1M ethylene glycol solution to terminate the oxidation reaction for 1 hour. Put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000 and place it in deionized water for dialysis. 3 days, and finally freeze-drying obtains aldehydated chitosan;

[0048] S2, weigh 1g of aldehylated chitosan, 0.5g of GelMA and 0.05g of lithium phenyl (2,4,6-trimethylbenzoyl) phosphate and mix it with phosphate buffer solution at 50°C, Filter with a 0.45 μm filter head to obtain the dispersed phase; then measure 40 mL of n-octane solution and 2 mL of Span-80 as the continuous phase, and use such as figure 1 The microfluidic devic...

Embodiment 2

[0053] S1, weigh 3g of sodium alginate and dissolve it in a three-necked brown flask filled with 60mL of deionized water, mix well under ultrasonic and heating conditions, adjust the pH to 3 with 0.1M HCl, and then add 20wt% NaIO to the reaction device 4 , at 40°C for 4 hours. After the reaction, add 6 mL of 0.1M ethylene glycol solution to terminate the oxidation reaction for 1.5 hours. Put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000 and place it in deionized water. Dialysis for 3 days, and finally freeze-drying to obtain alginate sodium alginate;

[0054] S2, weigh 1.5g of alginate sodium alginate, 0.8g of GelMA and mix with phosphate buffer solution evenly at 40°C, filter while hot with a 0.45μm filter head to obtain the dispersed phase; then measure 50mL of liquid paraffin and 3mL of Class-60 is used as the continuous phase, such as figure 1 The microfluidic device shown (the flow rate ratio of the dispersed phase and the contin...

Embodiment 3

[0059] S1, take 6g of starch and dissolve it in a three-necked brown flask with 100mL of deionized water, adjust the pH to 2 with 0.1M HCl, then add 10wt% NaIO to the reaction device 4 , oxidation reaction at 40°C for 4 hours, after the reaction, add 10mL 0.1M ethylene glycol solution to terminate the oxidation reaction for 2 hours, put the reaction solution into a dialysis bag with a molecular weight cut-off of 8000-14000, place it in deionized water for dialysis 3 days, and finally freeze-dried to obtain the formylated starch;

[0060] S2, weigh 2g of aldylated starch and 1g of GelMA and mix them evenly with phosphate buffer solution at 50°C, filter while hot with a 0.45μm filter head to obtain the dispersed phase; then measure 60mL of rapeseed oil and 4mL of Span-80 As the continuous phase, using such as figure 1 The microfluidic device shown (the flow rate ratio of the dispersed phase and the continuous phase is 1:20) prepares microsphere droplets to obtain microsphere dr...

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Abstract

The invention provides a medical natural polymer microsphere which is a hollow Schiff base natural polymer microsphere of a porous structure, wherein the porosity is 32.5-46.2%, the specific surface area is more than 16.3m<2>.G<-1>, and the diameter is 20-200 microns. The invention further provides a medical natural polymer microsphere containing radionuclides such as lutetium 177 and the like. The invention further provides a method for preparing the medical natural polymer microspheres containing radionuclides, which comprises the following steps of: oxidizing a linear long-chain natural polymer with a hydroxyl group into an aldehyde group natural polymer, uniformly mixing the aldehyde group natural polymer with a natural polymer with an amino group to serve as a dispersion phase, preparing microsphere liquid drops by adopting a microfluidic technology, carrying out ultralow-temperature freezing and Schiff base reaction to obtain Schiff base natural polymer microspheres with hollow porous structures, and adsorbing the radionuclides by the obtained microspheres to obtain the medical natural polymer microspheres containing the radionuclides. The medical natural polymer microspheres containing radionuclides prepared by adopting the method are good in monodispersity, uniform in size, injectable, compressible, fast in nuclide adsorption kinetics and low in release rate, and can be used for tumor radiotherapy and radiographic imaging diagnosis.

Description

technical field [0001] The invention relates to the field of polymer materials, a drug for tumor radiotherapy and tumor radiation imaging diagnosis and its preparation process, in particular to a medical natural polymer microsphere containing radionuclide and its preparation method and application. Background technique [0002] In my country, new cases of liver cancer each year account for 55% of the world, and the 5-year survival rate is only about 10%. Due to the lack of effective treatment methods, about 260,000 patients die of liver cirrhosis and liver cancer caused by hepatitis B in my country every year. Early detection and surgical resection are still the first choice for its treatment, but the recurrence rate is as high as 45.2% to 60%, and more than 70% of them have lung metastases. In addition, most liver cancers have no clinical symptoms in the early stage, and most of them are already in the middle and late stages when they are discovered, and the opportunity for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K51/08A61K51/06A61K9/16A61K47/36A61K47/42A61K31/704A61K33/243A61L24/00A61L24/08A61L24/10A61P35/00A61P35/04C08J9/28C08L5/08C08L5/04C08L3/02C08L1/28C08L5/00C08L5/06
CPCA61K51/1251A61K51/06A61K51/08A61K9/1652A61K9/1658A61P35/00A61P35/04A61K31/704A61K33/243A61L24/08A61L24/0015A61L24/001A61L24/0042A61L24/104C08J9/286C08J2305/08C08J2305/04C08J2303/02C08J2301/28C08J2305/00C08J2305/06C08L5/08
Inventor 刘刚徐晓马红娟楚成超陈虎高兴
Owner 厦门宏谱福生物科技有限公司
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