Preparation method of dependent electrospinning intravascular stent

Abstract

The invention relates to a preparation method of a dependent electrospinning intravascular stent, and belongs to the field of intravascular stents. The preparation method of the dependent electrospinning intravascular stent is characterized by comprising the following steps: dissolving a pH dependent material and PLGA mixed powder into trichloromethane to prepare a solution, and stirring the solution by a reinforcement stirrer to uniformly mix all components into one group; then, taking PLGA powder with the same mass, dissolving the PLGA powder in trichloromethane to prepare a solution, and stirring the solution by the reinforcement stirrer to prepare a second group; respectively sucking the prepared two groups of solutions by injectors, installing the injectors on a controllable injection pump of an electrostatic spinning device, connecting an anode of a high-voltage power supply with metal needles of the injectors, and connecting a cathode of the high-voltage power supply with a rod-shaped rotating shaft of a receiving device; and obtaining the tubular stent formed by nanofibers. The porosity of the prepared intravascular stent is basically consistent, the diameter of the nanofibers is smaller, the arrangement is more regular, and pH sensitivity is reserved. The mechanical strength, the tensile strength, the elongation at break and the bursting strength are all remarkably improved, and the mechanical property is relatively good.

Description

technical field [0001] The invention belongs to the field of vascular stents, in particular to a method for preparing a dependent electrospun vascular stent. Background technique [0002] Vascular diseases caused by various reasons not only cause great pain to patients, but also lead to difficulty in healing during angiogenesis and shortage of transplant sources. Or defects such as poor compatibility between the graft and the human body, even after the patient recovers, may affect the normal function of the corresponding parts of the human body or produce autologous rejection, which will aggravate the pain of the patient and make the patient's life bear a huge shadow. Going deep into the reason, the key problem to be solved in vascular defect disease is the shortage of blood vessel sources. In order to solve this problem, researchers have adopted many methods including autologous and allogeneic blood vessel transplantation for decades to try to solve this difficult problem. ...

AI Technical Summary

Problems solved by technology

[0002] Vascular diseases caused by various reasons not only cause great pain to patients, but also lead to difficulty in healing during angiogenesis and shortage of transplant sources

Or defects such as poor compatibility between the graft and the human body, even after the patient recovers, may affect the normal function of the corresponding parts of the human body or produce autologous rejection, which will aggravate the pain of the patient and make the patient's life suffer a huge shadow.