Zwitterionic polymer, and preparation method and application thereof

A zwitterion, polymer technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of high price and limited protein adsorption capacity, achieve simple operation, suitable for large-scale mass production, good safety effect

Pending Publication Date: 2021-06-29
黄石市森尔新型材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PVM/MA is expensive, and its anti-protein adsorption ability is limited, mai

Method used

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  • Zwitterionic polymer, and preparation method and application thereof
  • Zwitterionic polymer, and preparation method and application thereof
  • Zwitterionic polymer, and preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0039] The preparation method of above-mentioned zwitterionic polymer, comprises the following steps:

[0040] 1) Dissolving methacryloylethyl sultaine in water to obtain an aqueous solution of methacryloylethyl sultaine with a concentration of 50-100 mg / mL.

[0041] 2) Stirring, adding acrylic acid to the aqueous solution of methacryloyl ethyl sulfobetaine, and then adding an initiator, raising the temperature to 65-75° C. for 10-12 hours. The molar ratio of methacryloyl ethyl sulfobetaine to acrylic acid is 1: (0.5-2). The mass ratio of the initiator to the methacryloyl ethyl sulfobetaine is 1: (15-20).

[0042] 3) After the reaction is finished, drop the product into absolute ethanol for precipitation at a volume ratio of 1:1-5, and centrifuge for 5-10 minutes at a speed of 3000-5000 r / min, freeze-dry the precipitate for 18-24 hours to the target product.

[0043]The above-mentioned zwitterionic polymers can be used as active ingredients against exogenous stains, bacteri...

Embodiment 1

[0047] A zwitterionic polymer prepared by the following method:

[0048] 1) First weigh 2.79g of white powder of methacryloylethyl sulfobetaine into a single-necked flask, measure 35ml of deionized water into the flask, and stir for 10min at the same time to make methacryloylethyl sulfobetaine Alkali is dissolved in deionized water.

[0049] 2) Weigh 0.36g of acrylic acid (the molar ratio of the two raw materials is 1:0.5) and dissolve it in 10ml of deionized water, and add it into the flask in 1) after completely dissolving.

[0050] 3) Weigh 30 mg of the initiator ammonium persulfate and dissolve it in 5 ml of deionized water, add it into the flask in 1) after completely dissolving, start stirring, heat up to 65 degrees Celsius, and react for 12 hours.

[0051] 4) Drop the mixed liquid obtained after the reaction into a centrifuge tube filled with 80mL of absolute ethanol to precipitate out, put it in a centrifuge and centrifuge at a speed of 3500r / min for 10min, pour off t...

Embodiment 2

[0063] A zwitterionic polymer prepared by the following method:

[0064] 1) First weigh 2.79g of white powder of methacryloylethyl sulfobetaine into a single-necked flask, measure 35ml of deionized water into the flask, and stir for 10min at the same time to make methacryloylethyl sulfobetaine Alkali is dissolved in deionized water.

[0065] Weigh 0.72g of acrylic acid (the molar ratio of the two raw materials is 1:1) and dissolve it in 10ml of deionized water, and add it into the flask in 1) after completely dissolving.

[0066] 3) Weigh 35 mg of the initiator ammonium persulfate and dissolve it in 5 ml of deionized water, add it into the flask in 1) after completely dissolving, start stirring, heat up to 72 degrees Celsius, and react for 10 hours.

[0067] 4) Drop the mixed liquid obtained after the reaction into a centrifuge tube containing 100mL of absolute ethanol to precipitate out, put it in a centrifuge and centrifuge at 4000r / min for 10min, pour off the supernatant, ...

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Abstract

The invention relates to the field of high polymer materials, and discloses a zwitterionic polymer, and a preparation method and application thereof. The zwitterionic polymer disclosed by the invention is formed by copolymerizing acrylic acid and a zwitterionic monomer methacryloylethyl sulfobetaine, and a layer of compact polymer film can be formed on the surface of teeth, so that protein and bacteria in saliva can be prevented from being adsorbed on the surface of the teeth, and the effect of protecting the teeth is achieved. The zwitterionic polymer is applied to the oral care agent for the first time to serve as an active ingredient for resisting exogenous stains, bacteria and protein adsorption. The zwitterionic polymer disclosed by the invention is free of biotoxicity and good in safety, and does not stimulate mucous membranes to cause tooth sensitivity; secondly, the anti-stain timeliness is good; and thirdly, the polymer does not contain substances harmful to the environment, such as phosphorus, and belongs to environment-friendly substances.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a zwitterionic polymer and its preparation method and application. Background technique [0002] The formation process of dental plaque begins with the adsorption of nutrients in saliva on the tooth surface to form a base suitable for bacterial growth. After the bacteria adhere to it, they absorb nutrients and multiply and expand. After reaching a certain amount, dental plaque is formed. [0003] At present, in the field of teeth anti-spot whitening, the main chemical whitening methods can be divided into bleaching agent and pyrophosphate system. Among them, the most widely used bleaching agents are hydrogen peroxide and carbamide peroxide. The mechanism of the two is similar. They both form superoxide radicals and oxidize and reduce the colored substrate, so that the pigment fades or decomposes into small molecules. Whitening effect. The pyrophosphate system compound can chela...

Claims

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Application Information

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IPC IPC(8): C08F220/38C08F220/06A61K8/81A61Q11/00A61Q17/00
CPCC08F220/38A61K8/8152A61Q11/00A61Q17/005
Inventor 朱仕红邵旻
Owner 黄石市森尔新型材料有限公司
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