Application of Se@SiO2 nano-selenium core-shell material in flap transplantation
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A technology of nano-selenium and skin flaps, applied in the direction of sulfur/selenium/tellurium active ingredients, medical preparations of non-active ingredients, non-central analgesics, etc., to reduce skin flap necrosis, promote wound healing, and facilitate healing Effect
Inactive Publication Date: 2021-07-09
SHANGHAI FIRST PEOPLES HOSPITAL
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[0009] About the present invention Se@SiO 2 There are no relevant reports on the application of nano-selenium core-shell materials in skin flap transplantation
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Embodiment 1
[0039] Embodiment 1 Animal experiment
[0040] 1 material
[0041] The animals came from the Animal Center of Shanghai First People's Hospital, and the experimental procedures were approved by the Experimental Animal Ethics Committee of Shanghai First People's Hospital (the PermitNumber, 2018KY201.Shanghai, China). All experimental rats were anesthetized with pentobarbital. Minimize the suffering of experimental animals as much as possible. Rats were sacrificed by carbon dioxide asphyxiation.
[0042] 2 methods
[0043] 2.1 Model building method
[0044] SD rats were anesthetized by intraperitoneal injection of pentobarbital, and super-long random skin flaps on the back of the rats were designed with melanin on the back of the rats, with the iliac crest as the pedicle and the subscapular angle of the upper limbs as the end. Dosing of Se@SiO under skin flap 2 , and finally suture the wound. A 1.5 cm × 1.5 cm full-thickness flap tissue block was taken from the middle of th...
Embodiment 2
[0072] Embodiment 2 acute toxicity test
[0073] 1 method
[0074] Twenty female SD rats at 6-8 weeks were randomly divided into experimental group and control group after 7 days of adaptive feeding, with 10 rats in each group.
[0075] All rats in the test group were fasted from food and water at 10:00 p.m., weighed at 8:00 the next day, and fed Se@SiO 2 , once a day. Feed and water were given after gavage, and fasted again 1 hour before the next gavage.
[0076] Record as D on the day of gavage 0 . The control group was given an equal volume of normal saline. For 14 consecutive days, the body weight and food intake of the rats were detected, and the appearance, behavior, spirit, and acute toxic reactions such as vomiting, diarrhea, and convulsions of the rats were observed in the morning and evening, and whether the rats died.
[0077] 2 Experimental results
[0078] (1) Two groups of rats D 0 There was no statistically significant difference in initial body weight (...
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Abstract
The invention relates to an application of a Se@SiO2 nano-selenium core-shell material in skin flap transplantation. The Se@SiO2 nano-selenium core-shell material is composed of a silicon dioxide particle shell and a nano-selenium core; the Se@SiO2 nano-selenium core-shell material is creatively used in the skin flap transplantation, and the Se@SiO2 nano-selenium core-shell material can improve selenoprotein activity by supplementing selenium; selenoprotein can achieve anti-inflammatory and anti-apoptosis effects by regulating oxidation reduction, participates in regulating wound repair, promoting wound healing, protecting vascular endothelial cells and regulating microcirculation functions, and the material is administrated once, is slowly released and is effective for a long time, so that the local selenium element is proper in concentration, stable and long-acting, and meets the post-operation requirements of skin flap transplantation; experimental results show that the Se-coated SiO2 nano composite material has excellent anti-oxidative stress and anti-inflammatory capabilities, flap necrosis caused by insufficient local perfusion can be reduced, and a new idea is provided for improving the survival rate of transplanted flaps.
Description
technical field [0001] The invention relates to the technical field of medical drugs, specifically, Se@SiO 2 Application of nano-selenium core-shell material in skin flap transplantation. Background technique [0002] Skin flap transplantation is an important method for clinical treatment of large-scale soft tissue defects and skin repair and reconstruction. However, ischemia and necrosis of distal tissue of flap vessels after transplantation is still unavoidable. Skin flap transplantation is an important method for repairing tissue defect wounds, improving It is one of the important methods for deformity, restoration of shape and function, and organ reconstruction. In the treatment of severe traumatic tissue defects, it is an irreplaceable important technology to save the basic functions of patients and improve the quality of life of patients. Therefore, how to improve the survival rate after flap transplantation has always been an important research field. [0003] At pr...
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