Bismuth selenide hydrogel, bismuth selenide hydrogel bacterial carrier, and preparation method and application thereof

A bismuth selenide and hydrogel technology, applied in the directions of metal selenide/telluride, binary selenium/tellurium compounds, medical raw materials derived from bacteria, etc. It can achieve the effect of promoting establishment and balance, large X-ray attenuation coefficient, and good CT imaging function.

Active Publication Date: 2021-07-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing hydrogels are generally biologically inert, do not have specific biological functions, and are d

Method used

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  • Bismuth selenide hydrogel, bismuth selenide hydrogel bacterial carrier, and preparation method and application thereof
  • Bismuth selenide hydrogel, bismuth selenide hydrogel bacterial carrier, and preparation method and application thereof
  • Bismuth selenide hydrogel, bismuth selenide hydrogel bacterial carrier, and preparation method and application thereof

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preparation example Construction

[0071] According to the third aspect of the present invention, the present invention provides the preparation method of the above-mentioned bismuth selenide hydrogel, comprising the following steps: after uniformly mixing bismuth selenide nanoparticles and mercapto polyethylene glycol, the mixture of the two Disperse with sodium alginate in water, then add calcium lactate solution and mix evenly to obtain bismuth selenide hydrogel.

[0072] The preparation method of the bismuth selenide hydrogel provided by the invention has simple process, is easy to operate, and realizes large-scale production.

[0073] According to a fourth aspect of the present invention, the present invention provides a bismuth selenide hydrogel bacterial carrier, comprising the bismuth selenide hydrogel and bacteria provided in the first aspect of the present invention, and the bacteria are loaded on bismuth selenide water in the gel.

[0074] The bismuth selenide hydrogel bacterial carrier provided by ...

Embodiment 1

[0086] This embodiment provides a bismuth selenide hydrogel, which is prepared according to the following steps:

[0087] (1) 0.41g sodium alginate, 0.1g mercaptopolyethylene glycol stabilized bismuth selenide nanoparticles and 0.2g mercaptopolyethylene glycol were dissolved in 89.06g deionized water to obtain sodium alginate-bismuth selenide nanoparticles mixture;

[0088] (2) 0.23g calcium lactate is dissolved in 10g deionized water to obtain calcium lactate solution;

[0089] (3) Drop the calcium lactate solution into the sodium alginate-bismuth selenide nanoparticle mixed solution to obtain a bismuth selenide hydrogel, wherein the mass fraction of calcium alginate is 0.42%, the mass fraction of sodium lactate is 0.23%, and the mercaptopolyethylene The mass fraction of diol is 0.2%, the mass fraction of bismuth selenide nanoparticles stabilized by mercapto polyethylene glycol is 0.1%, and the mass fraction of water is 99.05%.

[0090] The bismuth selenide nanoparticles st...

Embodiment 2

[0093] This embodiment provides a bismuth selenide hydrogel, which is different from Example 1 in that in step (1), the amount of bismuth selenide nanoparticles stabilized by mercapto polyethylene glycol is 2.5g, and the mercapto polyethylene glycol The consumption of polyethylene glycol is 5g; In the bismuth selenide hydrogel prepared by step (3), the mass fraction of calcium alginate is 0.4%, the mass fraction of sodium lactate is 0.2%, and the mass fraction of mercaptopolyethylene glycol is 5%, The mass fraction of the bismuth selenide nanoparticles stabilized by mercapto polyethylene glycol is 2.5%, and the mass fraction of water is 91.9%.

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Abstract

The invention provides bismuth selenide hydrogel, a bismuth selenide hydrogel bacterial carrier, a preparation method and application thereof, and relates to the technical field of biomedical materials; the bismuth selenide hydrogel comprises the following components by mass: 0.4-4% of calcium alginate, 0.2-2.5% of sodium lactate, 0.02-10% of mercapto polyethylene glycol, 0.1-5% of bismuth selenide nanoparticles, and the balance of water. According to the bismuth selenide hydrogel provided by the invention, the bismuth selenide nanoparticles are introduced into the hydrogel, so that the bismuth selenide hydrogel not only can be used as a carrier of a drug and a flora to regulate release and metabolic behaviors of the drug and the flora in a body, but also has a good CT imaging function, can track the distribution position of the drug in the body, and can determine the optimal administration scheme and administration opportunity; meanwhile, the bismuth selenide hydrogel has excellent biocompatibility, mechanical property and water retention stability, and the in-vitro preservation time of the anaerobic flora can be effectively prolonged.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bismuth selenide hydrogel, a bismuth selenide hydrogel bacterial carrier, a preparation method and an application. Background technique [0002] A wide variety of microorganisms reside in the human gastrointestinal tract, and these microorganisms are called gut flora. They can synthesize a variety of vitamins necessary for human growth and development and promote the absorption of minerals. These nutrients play an important role in human health, and once they are deficient, they can cause various diseases. Therefore, maintaining the balance of intestinal flora is crucial to human health, and the destruction of intestinal flora by antibiotics or unhealthy diet can lead to obesity, gastrointestinal diseases, and even cancer. Probiotics in the gastrointestinal tract, such as Lactobacillus and Bifidobacterium strains, play an important role in protecting the intestin...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/12A61K47/20A61K47/02A61K9/06A61K35/74A61K35/745A61K35/747A61K35/744A61P1/12A61P1/00A61P25/24A61K49/04B82Y5/00B82Y40/00C01B19/04
CPCA61K47/36A61K47/12A61K47/20A61K47/02A61K9/06A61K35/74A61K35/745A61K35/747A61K35/744A61P1/12A61P1/00A61P25/24A61K49/04B82Y5/00B82Y40/00C01B19/007C01P2004/64C01P2004/62
Inventor 张琦曹若琪张玉珊王晶刘梓瑞李嫄渊焦旸朱巍曹建平祁小飞
Owner SUZHOU UNIV
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