Bismuth selenide hydrogel, bismuth selenide hydrogel bacterial carrier, and preparation method and application thereof

Abstract

The invention provides bismuth selenide hydrogel, a bismuth selenide hydrogel bacterial carrier, a preparation method and application thereof, and relates to the technical field of biomedical materials; the bismuth selenide hydrogel comprises the following components by mass: 0.4-4% of calcium alginate, 0.2-2.5% of sodium lactate, 0.02-10% of mercapto polyethylene glycol, 0.1-5% of bismuth selenide nanoparticles, and the balance of water. According to the bismuth selenide hydrogel provided by the invention, the bismuth selenide nanoparticles are introduced into the hydrogel, so that the bismuth selenide hydrogel not only can be used as a carrier of a drug and a flora to regulate release and metabolic behaviors of the drug and the flora in a body, but also has a good CT imaging function, can track the distribution position of the drug in the body, and can determine the optimal administration scheme and administration opportunity; meanwhile, the bismuth selenide hydrogel has excellent biocompatibility, mechanical property and water retention stability, and the in-vitro preservation time of the anaerobic flora can be effectively prolonged.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bismuth selenide hydrogel, a bismuth selenide hydrogel bacterial carrier, a preparation method and an application. Background technique [0002] A wide variety of microorganisms reside in the human gastrointestinal tract, and these microorganisms are called gut flora. They can synthesize a variety of vitamins necessary for human growth and development and promote the absorption of minerals. These nutrients play an important role in human health, and once they are deficient, they can cause various diseases. Therefore, maintaining the balance of intestinal flora is crucial to human health, and the destruction of intestinal flora by antibiotics or unhealthy diet can lead to obesity, gastrointestinal diseases, and even cancer. Probiotics in the gastrointestinal tract, such as Lactobacillus and Bifidobacterium strains, play an important role in protecting the intestin...

AI Technical Summary

Problems solved by technology

However, the existing hydrogels are generally biologically inert, do not have specific biological functions, and are difficult to achieve positioning in the body, resulting in the inability to choose the optimal dosing regimen and timing

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