N-substituted carbonyl fluorine sulfonamide compound as well as preparation method and application thereof

A carbonyl fluorosulfonamide and compound technology, which is applied in the preparation of sulfuric acid amide, organic chemistry, etc., can solve the problems of increased storage and use, no commercialization, and easy volatility, and achieves low toxicity, simple preparation, and wide substrate adaptability Effect
CN113121401AActive Publication Date: 2021-07-16中宏鑫投资控股(深圳)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
中宏鑫投资控股(深圳)有限公司
Publication Date
2021-07-16

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Abstract

The invention discloses an N-substituted carbonyl fluorine sulfonamide compound as well as a preparation method and application thereof. The N-substituted carbonyl fluorine sulfonamide compound comprises positive ions and negative ions, and the negative ions are shown in the formula I. The N-substituted carbonyl fluorine sulfonamide compound is low in toxicity, simple to prepare and convenient to use, is in a solid stable state at normal temperature, and reacts with a substrate to efficiently synthesize an N-amino carbonyl fluorine sulfonamide product; and besides, the compound is wide in substrate adaptability and can comprise primary amine and secondary amine compounds, so that the compound has important academic and application values.
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Description

technical field

[0001] The invention relates to an N-substituted carbonyl fluorosulfonamide compound, a preparation method and an application thereof. Background technique

[0002] The hexavalent sulfur-fluorine functional group exhibits mild reaction conditions, high efficiency, insensitivity to oxygen and water, no metal catalysis, wide range of substrates and special properties of orthogonality, making it widely used in chemistry, biology and materials, etc. field. Since Professor K.Barry Sharpless and Jiajia Dong first proposed and successfully realized the hexavalent sulfur-fluorine exchange reaction in 2014 (Angew.Chem.Int.Ed.2014, 9430), this type of reaction has been used in organic synthesis chemistry, material chemistry , medicinal chemistry, chemical biology, especially the selective labeling and modification of protein molecules, etc., have attracted extensive attention and shown good application prospects. It is called a new generation of click chemistry, which...

Claims

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