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Application of andrographolide derivative in preventing and treating plant diseases

A technology of andrographolide and derivatives is applied in the directions of chemicals, biocides, plant growth regulators, etc. for biological control, which can solve problems such as weak antibacterial activity, and achieve the effect of strong antibacterial activity and good antibacterial activity.

Pending Publication Date: 2021-07-20
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of resistance to plant diseases, there is currently only one article reporting that acetylandrographolide has weak antibacterial activity

Method used

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  • Application of andrographolide derivative in preventing and treating plant diseases
  • Application of andrographolide derivative in preventing and treating plant diseases
  • Application of andrographolide derivative in preventing and treating plant diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: Preparation of andrographolide derivatives

[0012] Compounds A-1 to A-16 (refer to European Journal of Medicinal Chemistry, 2017, 126, 920-928).

[0013] Obtained by referring to the synthesis method reported in the literature, the physical properties and nuclear magnetic mass spectrometry identification are consistent with the literature reports, and the andrographolide derivatives A-1 to A-16 listed in the claims are determined. All compounds were separated by conventional methods such as silica gel column chromatography to obtain pure products for further activity testing.

Embodiment 2

[0014] Embodiment 2: Determination of indoor antifungal activity

[0015] Mycelia growth rate method: According to a certain concentration gradient, add the test compound into the medium that has been sterilized and cooled to about 50°C, mix well, and dilute the agent into a series of concentrations to prepare a drug-containing medium. Each petri dish Inoculate a bacterial dish (diameter d=5mm), and set 3 replicates for each concentration. Cultivate at 25°C until the control colony covers more than 2 / 3 of the petri dish, measure the colony diameter (mm) of each concentration treatment by the cross method, calculate the growth inhibition rate of the drug on the mycelium, and use statistical software SAS8 for statistical analysis of differences .1 (Statistical Analysis System 8.1). The inhibitory effects of emodin halides on six plant pathogenic fungi were determined, and the results are shown in Table 1.

[0016] Table 1. Inhibitory activity of andrographolide derivatives aga...

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Abstract

The invention discloses application of an andrographolide derivative in preventing and treating crop diseases. The andrographolide derivative can be used for preventing and treating diseases caused by sclerotinia sclerotiorum, rhizoctonia solani, botrytis cinerea, fusarium graminearum, pyricularia grisea and phytophthora capsici. The andrographolide derivative shows good antibacterial activity to most of phytopathogens, especially has the strongest antibacterial activity to sclerotinia sclerotiorum, and can be further developed as a bactericidal lead compound.

Description

technical field [0001] The invention relates to the field of agricultural fungicides, more specifically, relates to the new application of andrographolide derivatives as fungicides in the control of crop diseases. Background technique [0002] Plant diseases seriously threaten the healthy development of agriculture and food security. The annual grain loss caused by plant diseases has exceeded 11% of the output. For example, paddy fields in my country are affected by rice sheath blight, causing a loss of 6 million tons of grain every year, and wheat is affected by head blight, causing a 10% to 30% reduction in production every year. The serious occurrence of plant diseases, the development of resistance of pathogenic bacteria and the abuse of chemical fungicides have aggravated the resistance of plant pathogens to fungicides, seriously threatening environmental safety and human health. Therefore, the research and development of new pesticides with high efficiency, low toxici...

Claims

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Application Information

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IPC IPC(8): A01N43/32A01P3/00
CPCA01N43/32
Inventor 张智军刘映前杨程杰张保琪贺颖慧
Owner LANZHOU UNIVERSITY
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