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Active composition for improving skin barrier function and preparation method thereof

A technology for improving skin and composition, applied in the field of hand cream, which can solve the problems of easy infection by bacteria and fungi, damage of skin barrier function, rough and peeling skin, etc., so as to reduce transepidermal water loss and enhance long-term moisturizing effect, the effect of enhancing skin permeability

Active Publication Date: 2022-02-18
无锡简玺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the improvement of living standards, people pay more attention to skin care. The daily chemical cleaning products will cause the destruction of sebum on the skin surface, which will lead to the reduction of sebum on the skin surface and excessive secretion of sebaceous glands, which will destroy the skin barrier function. Dry and lose luster. In severe cases, the skin is rough and peeled in winter, and it is easy to be infected by bacteria and fungi. Hand cream is a kind of skin care that can heal and smooth the skin cracks, dryness, and can effectively prevent and treat rough and chapped hands in autumn and winter. However, most of the traditional hand cream products only focus on replenishing water, ignoring the skin's water retention, and have not repaired the skin barrier function. The moisturizing components of many hand cream products are difficult to penetrate into the stratum corneum of the skin, and cannot last for a long time.

Method used

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  • Active composition for improving skin barrier function and preparation method thereof
  • Active composition for improving skin barrier function and preparation method thereof
  • Active composition for improving skin barrier function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of liposomes: Dissolve 4 parts of hydrogenated lecithin, 2 parts of ceramide 3, and 2 parts of cholesterol in 10 parts of ethanol, heat to 80° C. as oil phase; 1 part of small molecule sodium hyaluronate (molecular weight 40,000 ), 1 part of hydroxyethylpiperazine ethanesulfonic acid, dissolved in 80 parts of deionized water, heated to 80 ° C as the water phase; the oil phase and the water phase were loaded into glass syringes, and the syringes passed through the microtube and the microfluidic Control chip connection, adjust the injection flow rate of the syringe pump (model WZ-50C2): the ratio of the volume flow rate of the water phase channel on both sides of the microfluidic chip to the volume flow rate of the central oil phase channel V 水相 / V 油相 =8, the injection flow rate of the central oil phase channel is set to 0.2mg / min, liposomes are collected at the outlet, diafiltration is used to remove ethanol, and sterilized by filtration with a 0.22 μm filter...

Embodiment 2

[0037] Preparation of liposomes: Dissolve 6 parts of hydrogenated lecithin, 3 parts of ceramide 3, and 2 parts of cholesterol in 9 parts of ethanol, heat to 90 ° C, as the oil phase; 1.5 parts of small molecule sodium hyaluronate (molecular weight 40,000 ), 1.5 parts of hydroxyethylpiperazine ethanesulfonic acid, dissolved in 80 parts of deionized water, heated to 90 ° C as the water phase; the oil phase and the water phase were loaded into glass syringes, and the syringes passed through the microtube and microfluidic Control chip connection, adjust the injection flow rate of the syringe pump (WZ-50C2): the ratio of the volume flow rate of the water phase channel on both sides of the microfluidic chip to the volume flow rate of the central oil phase channel V 水相 / V 油相 =10, the injection flow rate of the central oil phase channel was set at 0.4 mg / min, liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration with a 0.22 μm filte...

Embodiment 3

[0042] Preparation of liposome: Dissolve 5 parts of hydrogenated lecithin, 3 parts of ceramide 3, and 2 parts of cholesterol in 10 parts of ethanol, heat to 80° C., as oil phase; 2 parts of small molecule sodium hyaluronate (molecular weight 40,000 ), 2 parts of hydroxyethylpiperazine ethanesulfonic acid, dissolved in 80 parts of deionized water, heated to 80 ° C as the water phase; the oil phase and the water phase were loaded into glass syringes, and the syringes passed through the microtube and the microfluidic Control chip connection, adjust the injection flow rate of the syringe pump (WZ-50C2): the ratio of the volume flow rate of the water phase channel on both sides of the microfluidic chip to the volume flow rate of the central oil phase channel V 水相 / V 油相 =6, the injection flow rate of the central oil phase channel was set at 0.3 mg / min, liposomes were collected at the outlet, ethanol was removed by diafiltration, and sterilized by filtration with a 0.22 μm filter mem...

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Abstract

The invention discloses an active composition for improving skin barrier function and a preparation method thereof, comprising: butanediol, glycerin, 1,2-hexanediol, squalane, unsaponifiable matter of olive oil, shea butter, Bis-Diglyceryl Polyacyl Adipate-2, Liposome, Cetearyl Glucoside, Cetearyl Alcohol, Polyglyceryl-10 Oleate, Polyvinylpyrrolidone, Adenosine, Magnesium PCA, Behenate Golden carnation extract, raspberry ketone, EDTA disodium, add water to 100 parts; the hand cream composition with improved hand skin barrier function of the present invention is aimed at hand skin due to less sebum secretion, or impaired barrier function And the skin is dry, rough, peeling and other problems, moisturizing and moisturizing at the same time, reducing transdermal water loss, moisturizing the skin, and has softening and anti-oxidation effects.

Description

technical field [0001] The invention belongs to the technical field of hand creams, and in particular relates to an active composition for improving skin barrier function and a preparation method thereof. Background technique [0002] With the improvement of living standards, people pay more attention to skin care. The daily chemical cleaning products will cause the destruction of sebum on the skin surface, which will lead to the reduction of sebum on the skin surface and excessive secretion of sebaceous glands, which will destroy the skin barrier function. Dry and lose luster. In severe cases, the skin is rough and peeled in winter, and it is easy to be infected by bacteria and fungi. Hand cream is a skin care that can heal and smooth the skin cracks, dryness, and can effectively prevent and treat rough and chapped hands in autumn and winter Products, however, most traditional hand cream products only focus on replenishing water, ignoring the skin's water retention, and hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/81A61K8/68A61K8/63A61K8/60A61K8/55A61K8/49A61K8/39A61K8/37A61K8/35A61K8/34A61K8/31A61Q19/00A61Q19/08
CPCA61K8/922A61K8/8176A61K8/68A61K8/63A61K8/602A61K8/553A61K8/494A61K8/39A61K8/375A61K8/35A61K8/345A61K8/342A61K8/31A61Q19/00A61Q19/08A61K2800/592A61K2800/524A61K2800/48
Inventor 简婷婷朱伟红
Owner 无锡简玺生物科技有限公司
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