Tunneling magnetoresistive biosensor and preparation method and application thereof

A biosensor and tunneling magneto-resistance technology, applied in magnetic sensor arrays, instruments, scientific instruments, etc., can solve the problems of low sensitivity of colloidal gold method and easy occurrence of missed detection, so as to improve detection sensitivity and detection rate , Improve the effect of signal-to-noise ratio
CN113189193APending Publication Date: 2021-07-30XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2021-07-30

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Abstract

The invention discloses a tunneling magnetoresistive biosensor and a preparation method and application thereof. The biosensor comprises a tunneling magnetoresistance multilayer film structure, a reaction area of the tunneling magnetoresistance biosensor, a biological sensitive film in the reaction area and magnetic beads for generating signals. The reaction area of the tunneling magnetoresistive biosensor is divided into a novel coronavirus IgM antibody detection area, a negative control area and a novel coronavirus IgG antibody detection area, the novel coronavirus IgM antibody detection area fixes an anti-human IgM antibody, the negative control area modifies bovine serum albumin, and the novel coronavirus IgG antibody detection area fixes an anti-human IgG antibody. The tunneling magnetoresistive biosensor is more accurate in result, high in sensitivity, simple and convenient to operate, free of operation by professionals, low in detection cost and suitable for field detection of communities, airports, families and the like, and an effective means is provided for rapid screening of novel coronaviruses.
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Description

technical field

[0001] The invention belongs to the technical field of biological detection sensors, in particular to a tunneling magnetoresistive biosensor, a preparation method and application thereof. Background technique

[0002] At present, the main detection method for the new coronavirus is fluorescent PCR. However, the positive rate of nucleic acid detection of nasopharyngeal swabs is only 30%-50%, and there are a large number of false negative results. The detection principle of fluorescent PCR is to amplify the target sequence in the sample. After amplification, the amount of nucleic acid is sufficient for detection by fluorescence. Therefore, the positive rate of detection is closely related to the amount of nucleic acid. Due to the different virus content in patients with different disease courses and different conditions; the new coronavirus with single-stranded RNA is easily degraded by RNase; the virus genome may mutate, and the sensitivity and specificity of ...

Claims

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