A kind of preparation method of the polymer of lipoic acid compound

Abstract

The invention discloses a method for preparing a polymer of lipoic acid compounds, which is selected from solvent-free direct hot-melt catalytic polymerization or room temperature solution catalytic polymerization; the catalyst used in the method of the invention has a wide range of sources, is easy to prepare, and is inexpensive. Inexpensive, diverse catalytic methods and simple process, no metal ions, only a small amount of catalyst is needed to achieve high-efficiency catalysis, and has practical industrial feasibility; it can catalyze polymerization under the condition of direct heating and melting without solvent, or at room temperature Catalytic polymerization in the solution under the environment; the direct hot melt catalytic method does not need any organic solvent, the catalytic process is rapid, the conditions are mild, the operation is simple and safe, the utilization rate of atoms is high, and there is no three wastes, which meets the requirements of green chemistry; the room temperature solution catalytic method does not need heating and complicated High-efficiency catalytic polymerization at room temperature can be achieved by adding a small amount of catalyst to the monomer solution.

Description

Technical field [0001] The present invention belongs to the chemical technology of polymer material, and more particularly to a method of preparing a polymer of a sulfic acid compound. Background technique [0002] Disulfide bond is a dynamic covalent bond existing in the living body. It is an important part of protein secondary and third-level structures. It has an important role in the stability of the peptide chain structure and the stereoscopic form of protein molecules. Due to its relatively low key energy (251 kJ / mol), the disulfide bond has a dynamic reversibility similar to the super molecule, and can realize the disconnection and reconnection of the S-S bond under external conditions. For a cyclic compound containing a disulfide bond, the disulfide bond is utilized under certain conditions such that the disulfide bond is disconnected in the molecule, and then reconnects between the molecules, this characteristic makes it open The loop polymerization shows huge potentia...

AI Technical Summary

Problems solved by technology

Direct thermal polymerization and photopolymerization mainly use the disulfide bond breakage under the action of heat or light to generate sulfur free radicals, and the sulfur free radicals between different molecules are connected to each other to form bonds again, so as to realize ring-opening polymerization, thermal polymerization and photopolymerization conditions Mild, simple process, fast preparation, high atom utilization, but there are also disadvantages such as difficulty in controlling the configuration and molecular weight, and the need for additional cross-linking agents to quench excess free radicals; the thiol induction method is passed in alkaline solution Sulfide anion triggers disulfide bond ring-opening polymerization chain reaction, the reaction can be completed at room temperature, high conversion rate can be achieved in a short time, and the structure of the polymer can be precisely controlled under specific conditions, but this The method needs to be carried out in a strictly anhydrous and oxygen-free organic solvent, which is not suitable for monomers containing carboxyl groups, and requires the participation of organic bases, mercaptans, and quenchers at the same time, and the reaction conditions are relatively complicated (Architecture-controlled ring-openingpolymerization for dynamic covalentpoly(disulfide)s[J].J.Am.Chem.Soc.,2019,141(43):17075-17080.)

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